DOI: 10.1126/science.1070502. Oscillations and Sparsening of Odor Representations in the Mushroom Body

Oscillations and Sparsening of Odor Representations in the Mushroom Body

10.1126/science.1070502

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

In the insect olfactory system, oscillatory synchronization is functionally relevant and reflects the coherent activation of dynamic neural assemblies. We examined the role of such oscillatory synchronization in information transfer between networks in this system. The antennal lobe is the obligatory relay for olfactory afferent signals and generates oscillatory output. The mushroom body is responsible for formation and retrieval of olfactory and other memories. The format of odor representations differs significantly across these structures. Whereas representations are dense, dynamic, and seemingly redundant in the antennal lobe, they are sparse and carried by more selective neurons in the mushroom body. This transformation relies on a combination of oscillatory dynamics and intrinsic and circuit properties that act together to selectively filter and synthesize the output from the antennal lobe. These results provide direct support for the functional relevance of correlation codes and shed some light on the role of oscillatory synchronization in sensory networks.

Bibliography

Perez-Orive, J., Mazor, O., Turner, G. C., Cassenaer, S., Wilson, R. I., & Laurent, G. (2002). Oscillations and Sparsening of Odor Representations in the Mushroom Body. Science, 297(5580), 359â365.

Authors 6

Javier Perez-Orive (first)
Ofer Mazor (additional)
Glenn C. Turner (additional)
Stijn Cassenaer (additional)
Rachel I. Wilson (additional)
Gilles Laurent (additional)

References 60 Referenced 647

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Supported by the National Institute for Deafness and other Communication Disorders; the National Science Foundation; the McKnight Alfred P. Sloan and Keck Foundations (G.L.); a Sloan and Swartz Foundations fellowship (J.P.-O.); a Department of Defense National Defense Science and Engineering graduate fellowship (O.M.); the Elizabeth Ross fellowship (G.C.T.); and a Helen Hay Whitney postdoctoral fellowship (R.I.W.). We thank M. Westman for his intracellular PN data; C. Pouzat for help with spike sorting; S. Farivar for help with the immunocytochemistry; the Laurent Lab; E. Schuman A. Siapas and C. Mead for discussions; M. Roukes for help with silicon tetrodes; I. Lubenov and A. Siapas for help with wire tetrodes; M. Walsh for electronics; and the Caltech Biological Imaging Center for their resources and expertise. Multichannel silicon probes were provided by the University of Michigan Center for Neural Communication Technology sponsored by NIH NCRR grant no. P41-RR09754. Supporting Online Material www.sciencemag.org/cgi/content/full/297/5580/359/DC1 Materials and Methods SFigs. 1 to S5 Movie S1

Dates

Type	When
Created	23 years, 1 month ago (July 28, 2002, 7:06 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 11:51 p.m.)
Indexed	2 months ago (July 2, 2025, 2:11 a.m.)
Issued	23 years, 1 month ago (July 19, 2002)
Published	23 years, 1 month ago (July 19, 2002)
Published Print	23 years, 1 month ago (July 19, 2002)

Funders 0

None

BibTeX

@article{Perez_Orive_2002, title={Oscillations and Sparsening of Odor Representations in the Mushroom Body}, volume={297}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1070502}, DOI={10.1126/science.1070502}, number={5580}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Perez-Orive, Javier and Mazor, Ofer and Turner, Glenn C. and Cassenaer, Stijn and Wilson, Rachel I. and Laurent, Gilles}, year={2002}, month=jul, pages={359–365} }

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        "id-type": "doi",
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    ]
  },
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        2002,
        7,
        19
      ]
    ]
  }
}