DOI: 10.1126/science.1067466. Emerging Roles of Ubiquitin in Transcription Regulation

Emerging Roles of Ubiquitin in Transcription Regulation

10.1126/science.1067466

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Ubiquitin is a small protein that was initially found to function as a tag that can be covalently attached to proteins to mark them for destruction by a multisubunit, adenosine 5′-triphosphate–dependent protease called the proteasome. Ubiquitin is now emerging as a key regulator of eukaryotic messenger RNA synthesis, a process that depends on the RNA synthetic enzyme RNA polymerase II and the transcription factors that control its activity. Ubiquitin controls messenger RNA synthesis not only by mechanisms involving ubiquitin-dependent destruction of transcription factors by the proteasome, but also by an intriguing collection of previously unknown and unanticipated mechanisms that appear to be independent of the proteasome.

Bibliography

Conaway, R. C., Brower, C. S., & Conaway, J. W. (2002). Emerging Roles of Ubiquitin in Transcription Regulation. Science, 296(5571), 1254â1258.

Authors 3

Ronald C. Conaway (first)
Christopher S. Brower (additional)
Joan Weliky Conaway (additional)

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Work in the author's laboratory is supported by NIH grant R37 6M41628 (to R.C.C.).

Dates

Type	When
Created	23 years ago (July 27, 2002, 5:54 a.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 5:32 p.m.)
Indexed	4 weeks, 2 days ago (July 25, 2025, 5:57 a.m.)
Issued	23 years, 3 months ago (May 17, 2002)
Published	23 years, 3 months ago (May 17, 2002)
Published Print	23 years, 3 months ago (May 17, 2002)

Funders 0

None

BibTeX

@article{Conaway_2002, title={Emerging Roles of Ubiquitin in Transcription Regulation}, volume={296}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1067466}, DOI={10.1126/science.1067466}, number={5571}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Conaway, Ronald C. and Brower, Christopher S. and Conaway, Joan Weliky}, year={2002}, month=may, pages={1254–1258} }

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