DOI: 10.1126/science.1067431. Stromal Effects on Mammary Gland Development and Breast Cancer

Stromal Effects on Mammary Gland Development and Breast Cancer

10.1126/science.1067431

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Breast cancer manifests itself in the mammary epithelium, yet there is a growing recognition that mammary stromal cells also play an important role in tumorigenesis. During its developmental cycle, the mammary gland displays many of the properties associated with breast cancer, and many of the stromal factors necessary for mammary development also promote or protect against breast cancer. Here we review our present knowledge of the specific factors and cell types that contribute to epithelial-stromal crosstalk during mammary development. To find cures for diseases like breast cancer that rely on epithelial-stromal crosstalk, we must understand how these different cell types communicate with each other.

Bibliography

Wiseman, B. S., & Werb, Z. (2002). Stromal Effects on Mammary Gland Development and Breast Cancer. Science, 296(5570), 1046â1049.

Authors 2

Bryony S. Wiseman (first)
Zena Werb (additional)

References 43 Referenced 638

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10.1126/science.1066282
Supported by National Cancer Institute grant CA57621 U.S. Department of Defense Breast Cancer program grant DAMD17-99-1-9113 and Human Frontier Science Program grant RG0051/1999-M. We thank J. Lilla and B. Welm for advice. We apologize to authors whose work could not be cited because of length restrictions.

Dates

Type	When
Created	23 years ago (July 27, 2002, 5:54 a.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 4:39 p.m.)
Indexed	1 day, 4 hours ago (Aug. 23, 2025, 12:59 a.m.)
Issued	23 years, 3 months ago (May 10, 2002)
Published	23 years, 3 months ago (May 10, 2002)
Published Print	23 years, 3 months ago (May 10, 2002)

Funders 0

None

BibTeX

@article{Wiseman_2002, title={Stromal Effects on Mammary Gland Development and Breast Cancer}, volume={296}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1067431}, DOI={10.1126/science.1067431}, number={5570}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Wiseman, Bryony S. and Werb, Zena}, year={2002}, month=may, pages={1046–1049} }

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      "unstructured": "Supported by National Cancer Institute grant CA57621 U.S. Department of Defense Breast Cancer program grant DAMD17-99-1-9113 and Human Frontier Science Program grant RG0051/1999-M. We thank J. Lilla and B. Welm for advice. We apologize to authors whose work could not be cited because of length restrictions."
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