DOI: 10.1126/science.1065467. Cell Proliferation Without Neurogenesis in Adult Primate Neocortex

Cell Proliferation Without Neurogenesis in Adult Primate Neocortex

10.1126/science.1065467

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

A recent assertion that new neurons are continually added to the neocortex of adult macaque monkeys has profound implications for understanding the cellular mechanisms of higher cognitive functions. Here we searched for neurogenesis in adult macaques by using immunofluorescent triple labeling for the DNA-replication indicator, bromodeoxyuridine (BrdU), and neuronal and glial cell markers. Although numerous BrdU-labeled cells were distributed throughout the cerebral wall, including the neocortex, these were identified as nonneuronal cells; evidence for newly generated neurons was limited to the hippocampus and olfactory bulb. Thus, our results do not substantiate the claim of neurogenesis in normal adult primate neocortex.

Bibliography

Kornack, D. R., & Rakic, P. (2001). Cell Proliferation Without Neurogenesis in Adult Primate Neocortex. Science, 294(5549), 2127â2130.

Authors 2

David R. Kornack (first)
Pasko Rakic (additional)

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We thank P. S. Goldman-Rakic E. A. Markakis and N. Sestan for insightful comments. Supported by grants NS14841 and EY02593 from the United States Public Health Service.

Dates

Type	When
Created	23 years ago (July 27, 2002, 5:47 a.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 5:30 p.m.)
Indexed	1 month ago (July 25, 2025, 6:38 a.m.)
Issued	23 years, 8 months ago (Dec. 7, 2001)
Published	23 years, 8 months ago (Dec. 7, 2001)
Published Print	23 years, 8 months ago (Dec. 7, 2001)

Funders 0

None

BibTeX

@article{Kornack_2001, title={Cell Proliferation Without Neurogenesis in Adult Primate Neocortex}, volume={294}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1065467}, DOI={10.1126/science.1065467}, number={5549}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Kornack, David R. and Rakic, Pasko}, year={2001}, month=dec, pages={2127–2130} }

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