DOI: 10.1126/science.1064020. Imprinting and the Epigenetic Asymmetry Between Parental Genomes

Imprinting and the Epigenetic Asymmetry Between Parental Genomes

10.1126/science.1064020

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Genomic imprinting confers a developmental asymmetry on the parental genomes, through epigenetic modifications in the germ line and embryo. These heritable modifications regulate the monoallelic activity of parental alleles resulting in their functional differences during development. Specific cis -acting regulatory elements associated with imprinted genes carry modifications involving chromatin structural changes and DNA methylation. Some of these modifications are initiated in the germ line. Comparative genomic analysis at imprinted domains is emerging as a powerful tool for the identification of conserved elements amenable to more detailed functional analysis, and for providing insight into the emergence of imprinting during the evolution of mammalian species. Genomic imprinting therefore provides a model system for the analysis of the epigenetic control of genome function.

Bibliography

Ferguson-Smith, A. C., & Surani, M. A. (2001). Imprinting and the Epigenetic Asymmetry Between Parental Genomes. Science, 293(5532), 1086â1089.

Authors 2

Anne C. Ferguson-Smith (first)
M. Azim Surani (additional)

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{newshr}Review

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 5:39 a.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 4:13 p.m.)
Indexed	1 week, 4 days ago (Aug. 21, 2025, 2:16 p.m.)
Issued	24 years ago (Aug. 10, 2001)
Published	24 years ago (Aug. 10, 2001)
Published Print	24 years ago (Aug. 10, 2001)

Funders 0

None

BibTeX

@article{Ferguson_Smith_2001, title={Imprinting and the Epigenetic Asymmetry Between Parental Genomes}, volume={293}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1064020}, DOI={10.1126/science.1064020}, number={5532}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Ferguson-Smith, Anne C. and Surani, M. Azim}, year={2001}, month=aug, pages={1086–1089} }

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