Quinones as the Redox Signal for the Arc Two-Component System of Bacteria
10.1126/science.1059361
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The Arc two-component signal transduction system mediates adaptive responses of Escherichia coli to changing respiratory conditions of growth. Under anaerobic conditions, the ArcB sensor kinase autophosphorylates and then transphosphorylates ArcA, a global transcriptional regulator that controls the expression of numerous operons involved in respiratory or fermentative metabolism. We show that oxidized forms of quinone electron carriers act as direct negative signals that inhibit autophosphorylation of ArcB during aerobiosis. Thus, the Arc signal transduction system provides a link between the electron transport chain and gene expression.

Bibliography

Georgellis, D., Kwon, O., & Lin, E. C. C. (2001). Quinones as the Redox Signal for the Arc Two-Component System of Bacteria. Science, 292(5525), 2314–2316.

Authors 3
  1. Dimitris Georgellis (first)
  2. Ohsuk Kwon (additional)
  3. Edmund C. C. Lin (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 5:53 a.m.)
Deposited 1 year, 7 months ago (Jan. 9, 2024, 5:21 p.m.)
Indexed 2 days, 19 hours ago (Sept. 2, 2025, 6:35 a.m.)
Issued 24 years, 2 months ago (June 22, 2001)
Published 24 years, 2 months ago (June 22, 2001)
Published Print 24 years, 2 months ago (June 22, 2001)
Funders 0

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@article{Georgellis_2001, title={Quinones as the Redox Signal for the Arc Two-Component System of Bacteria}, volume={292}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1059361}, DOI={10.1126/science.1059361}, number={5525}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Georgellis, Dimitris and Kwon, Ohsuk and Lin, Edmund C. C.}, year={2001}, month=jun, pages={2314–2316} }