DOI: 10.1126/science.1056794. The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains

The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains

10.1126/science.1056794

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The chromosomal position of human genes is rapidly being established. We integrated these mapping data with genome-wide messenger RNA expression profiles as provided by SAGE (serial analysis of gene expression). Over 2.45 million SAGE transcript tags, including 160,000 tags of neuroblastomas, are presently known for 12 tissue types. We developed algorithms to assign these tags to UniGene clusters and their chromosomal position. The resulting Human Transcriptome Map generates gene expression profiles for any chromosomal region in 12 normal and pathologic tissue types. The map reveals a clustering of highly expressed genes to specific chromosomal regions. It provides a tool to search for genes that are overexpressed or silenced in cancer.

Bibliography

Caron, H., Schaik, B. van, Mee, M. van der, Baas, F., Riggins, G., Sluis, P. van, Hermus, M.-C., Asperen, R. van, Boon, K., VouÌte, P. A., Heisterkamp, S., Kampen, A. van, & Versteeg, R. (2001). The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains. Science, 291(5507), 1289â1292.

Authors 13

Huib Caron (first)
Barbera van Schaik (additional)
Merlijn van der Mee (additional)
Frank Baas (additional)
Gregory Riggins (additional)
Peter van Sluis (additional)
Marie-Christine Hermus (additional)
Ronald van Asperen (additional)
Kathy Boon (additional)
P. A. Voûte (additional)
Siem Heisterkamp (additional)
Antoine van Kampen (additional)
Rogier Versteeg (additional)

References 18 Referenced 552

10.1126/science.282.5389.744
10.1126/science.270.5235.484
Supplemental Web material is available at www.sciencemag.org/cgi/content/full/291/5507/1289/DC1.
The Human Transcriptome Map is available at .
Lal A., et al., Cancer Res. 59, 5403 (1999). / Cancer Res. by Lal A. (1999)
Velculescu V. E., et al., Nature Genet. 23, 387 (1999). (10.1038/70487) / Nature Genet. by Velculescu V. E. (1999)
Craig J. M., Bickmore W. A., Nature Genet. 7, 376 (1994). (10.1038/ng0794-376) / Nature Genet. by Craig J. M. (1994)
10.1016/S0092-8674(00)81845-0
10.1016/0092-8674(90)90141-Z
Schwab M., et al., Nature 305, 245 (1983). (10.1038/305245a0) / Nature by Schwab M. (1983)
N. Spieker et al. Genomics in press.
The
Sequencing Consortium MHC, Nature 401, 921 (1999). (10.1038/44853) / Nature by Sequencing Consortium MHC (1999)
10.1038/35012518
Wansink D. G., et al., J. Cell Biol. 122, 283 (1993). (10.1083/jcb.122.2.283) / J. Cell Biol. by Wansink D. G. (1993)
Wei X., Somanathan S., Samarabandu J., Berezney R., J. Cell Biol. 146, 543 (1999). (10.1083/jcb.146.3.543) / J. Cell Biol. by Wei X. (1999)
Jackson D. A., Iborra F. J., Manders E. M., Cook P. R., Mol. Biol. Cell 9, 1523 (1998). (10.1091/mbc.9.6.1523) / Mol. Biol. Cell by Jackson D. A. (1998)
We thank A. Luyf and A. Sha Sawari for their help in computational analyses A. Lash for use of the SAGEmap database and help in tag analyses and E. Roos for expert digital imaging. Supported by grants from the Stichting Kindergeneeskundig Kankeronderzoek the A. Meelmeijer Fund and the Dutch Cancer Society. H.C. is a fellow of the Dutch Royal Academy of Sciences.

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 5:48 a.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 4:43 p.m.)
Indexed	3 weeks, 3 days ago (Aug. 5, 2025, 8:27 a.m.)
Issued	24 years, 6 months ago (Feb. 16, 2001)
Published	24 years, 6 months ago (Feb. 16, 2001)
Published Print	24 years, 6 months ago (Feb. 16, 2001)

Funders 0

None

BibTeX

@article{Caron_2001, title={The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains}, volume={291}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1056794}, DOI={10.1126/science.1056794}, number={5507}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Caron, Huib and Schaik, Barbera van and Mee, Merlijn van der and Baas, Frank and Riggins, Gregory and Sluis, Peter van and Hermus, Marie-Christine and Asperen, Ronald van and Boon, Kathy and Voûte, P. A. and Heisterkamp, Siem and Kampen, Antoine van and Versteeg, Rogier}, year={2001}, month=feb, pages={1289–1292} }

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