DOI: 10.1124/mol.62.5.971. Dancing with Different Partners: Protein Kinase A Phosphorylation of Seven Membrane-Spanning Receptors Regulates Their G Protein-Coupling Specificity

Dancing with Different Partners: Protein Kinase A Phosphorylation of Seven Membrane-Spanning Receptors Regulates Their G Protein-Coupling Specificity

10.1124/mol.62.5.971

Crossref journal-article

Elsevier BV

Molecular Pharmacology (78)

Bibliography

Lefkowitz, R. J., Pierce, K. L., & Luttrell, L. M. (2002). Dancing with Different Partners: Protein Kinase A Phosphorylation of Seven Membrane-Spanning Receptors Regulates Their G Protein-Coupling Specificity. Molecular Pharmacology, 62(5), 971â974.

Authors 3

Robert J. Lefkowitz (first)
Kristen L. Pierce (additional)
Louis M. Luttrell (additional)

References 23 Referenced 148

10.1016/S0021-9258(18)88892-5 / J Biol Chem by Benovic (1985)
10.1016/S0021-9258(18)89619-3 / J Biol Chem / Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. by Cerione (1985)
10.1126/science.7694367 / Science (Wash DC) / Inhibition by cAMP of Ras-dependent activation of Raf. by Cook (1993)
10.1074/jbc.270.42.25259 / J Biol Chem / Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a βγ-dependent activation and a Gαs-cAMP-mediated inhibition. by Crespo (1995)
10.1038/36362 / Nature (Lond) / Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. by Daaka (1997)
10.1124/mol.62.5.1094 / Mol Pharmacol / β2-Adrenergic receptor lacking the protein kinase A consensus sites fully activates extracellular signal-regulated kinase 1/2 in human embryonic kidney 293 cells: lack of evidence for Gs/Gi switching. by Friedman (2002)
Gutkind JS (2000) Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors. Sci STKE (http://stke.sciencemag.org/cgi/content/full/sigtrans;2000/40/re1). (10.1126/scisignal.402000re1)
{'key': '10.1124/mol.62.5.971_bib8', 'first-page': 'A199', 'article-title': 'Cardiac-specific 200-fold overexpression of human β2-adrenoceptors (β2AR) in mice (TG4) exposes pleiotropy in G protein coupling.', 'volume': '44(Suppl. 1)', 'author': 'Hasseldine', 'year': '2002', 'journal-title': 'Pharmacologist'} / Pharmacologist / Cardiac-specific 200-fold overexpression of human β2-adrenoceptors (β2AR) in mice (TG4) exposes pleiotropy in G protein coupling. by Hasseldine (2002)
10.1074/jbc.M104434200 / J Biol Chem / Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to Gs-, to Gi- and to Gq-coupled effector signaling. by Lawler (2001)
10.1038/35017152 / Nat Cell Biol / The superfamily of heptahelical receptors. by Lefkowitz (2000)
10.1074/jbc.274.25.17684 / J Biol Chem / Alternate coupling of receptors to Gs and Gi in pancreatic and submandibular gland cells. by Luo (1999)
10.1016/S0955-0674(99)80023-4 / Curr Opin Cell Biol / Regulation of tyrosine kinase cascades by G-protein-coupled receptors. by Luttrell (1999)
10.1074/jbc.275.13.9572 / J Biol Chem / The β2-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. by Maudsley (2000)
10.1074/jbc.M203353200 / J Biol Chem / Investigation of the mechanisms of G protein: effector coupling by the human and mouse prostacyclin receptors. Identification of critical species-dependent differences. by Miggin (2002)
10.1016/0092-8674(91)90067-9 / Cell / Identification of a Gs activator region of the beta 2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation. by Okamoto (1991)
10.1021/bi00127a021 / Biochemistry / Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase and protein kinase C occurs via distinct molecular mechanisms. by Pitcher (1992)
10.1074/jbc.M003213200 / J Biol Chem / β2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-Raf. by Schmitt (2000)
10.1016/S1097-2765(01)00432-4 / Mol Cell / PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1. by Schmitt (2002)
10.1074/jbc.273.23.14533 / J Biol Chem / Analysis of the Gs/mitogen-activated protein kinase pathway in mutant S49 cells. by Wan (1998)
10.1126/science.7694366 / Science (Wash DC) / Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate. by Wu (1993)
10.1074/jbc.M202753200 / J Biol Chem / Protein kinase A-mediated phosphorylation of the β2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system. by Zamah (2002)
10.1073/pnas.98.4.1607 / Proc Natl Acad Sci USA / Dual modulation of cell survival and cell death by β2-adrenergic signaling in adult mouse cardiac myocytes. by Zhu (2001)
10.1074/jbc.274.14.9760 / J Biol Chem / Both Gs and Gi proteins are critically involved in isoproterenol-induced cardiomyocyte hypertrophy. by Zou (1999)

Dates

Type	When
Created	22 years, 7 months ago (Jan. 15, 2003, 6:12 p.m.)
Deposited	6 months, 1 week ago (Feb. 20, 2025, 5:17 a.m.)
Indexed	1 month, 1 week ago (July 20, 2025, 12:30 a.m.)
Issued	22 years, 9 months ago (Nov. 1, 2002)
Published	22 years, 9 months ago (Nov. 1, 2002)
Published Print	22 years, 9 months ago (Nov. 1, 2002)

Funders 0

None

BibTeX

@article{Lefkowitz_2002, title={Dancing with Different Partners: Protein Kinase A Phosphorylation of Seven Membrane-Spanning Receptors Regulates Their G Protein-Coupling Specificity}, volume={62}, ISSN={0026-895X}, url={http://dx.doi.org/10.1124/mol.62.5.971}, DOI={10.1124/mol.62.5.971}, number={5}, journal={Molecular Pharmacology}, publisher={Elsevier BV}, author={Lefkowitz, Robert J. and Pierce, Kristen L. and Luttrell, Louis M.}, year={2002}, month=nov, pages={971–974} }

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