DOI: 10.1124/mol.105.016741. Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs

Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs

10.1124/mol.105.016741

Crossref journal-article

Elsevier BV

Molecular Pharmacology (78)

Bibliography

Perry, M., Stansfeld, P. J., Leaney, J., Wood, C., de Groot, M. J., Leishman, D., Sutcliffe, M. J., & Mitcheson, J. S. (2006). Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs. Molecular Pharmacology, 69(2), 509â519.

Authors 8

Matthew Perry (first)
Phillip J. Stansfeld (additional)
Joanne Leaney (additional)
Claire Wood (additional)
Marcel J. de Groot (additional)
Derek Leishman (additional)
Michael J. Sutcliffe (additional)
John S. Mitcheson (additional)

References 38 Referenced 73

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10.1021/jm0208875 / J Med Chem / Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K+ channel blockers by Cavalli (2002)
10.1073/pnas.192367299 / Proc Natl Acad Sci USA / Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels by Chen (2002)
10.1126/science.280.5360.69 / Science (Wash DC) / The structure of the potassium channel: molecular basis of K+ conduction and selectivity by Doyle (1998)
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10.1074/jbc.M310683200 / J Biol Chem / Physicochemical features of the HERG channel drug binding site by Fernandez (2004)
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10.1038/sj.bjp.0705025 / Br J Pharmacol / Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241 by Gessner (2003)
10.1124/mol.65.5.1120 / Mol Pharmacol / Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents by Gessner (2004)
10.1111/j.1469-7793.1998.003bi.x / J Physiol / Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels by Herzberg (1998)
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10.1016/0304-4157(77)90003-X / Biochim Biophys Acta / Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels by Hondeghem (1977)
10.1006/jmbi.1996.0897 / J Mol Biol / Development and validation of a genetic algorithm for flexible docking by Jones (1997)
10.1016/S0026-895X(24)23126-6 / Mol Pharmacol / Open channel block of HERG K+ channels by vesnarinone by Kamiya (2001)
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10.1016/S0026-895X(24)23209-0 / Mol Pharmacol / Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: involvement of S6 sites by Lees-Miller (2000)
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10.1073/pnas.210244497 / Proc Natl Acad Sci USA / A structural basis for drug-induced long QT syndrome by Mitcheson (2000)
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{'key': '10.1124/mol.105.016741_bib22', 'first-page': '667', 'article-title': 'Molecular determinants of high-affinity drug binding to HERG channels', 'volume': '6', 'author': 'Mitcheson', 'year': '2003', 'journal-title': 'Curr Opin Drug Disc Dev'} / Curr Opin Drug Disc Dev / Molecular determinants of high-affinity drug binding to HERG channels by Mitcheson (2003)
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Dates

Type	When
Created	19 years, 9 months ago (Nov. 16, 2005, 8:34 p.m.)
Deposited	6 months, 2 weeks ago (Feb. 19, 2025, 7 a.m.)
Indexed	1 month, 1 week ago (July 28, 2025, 2:52 a.m.)
Issued	19 years, 7 months ago (Feb. 1, 2006)
Published	19 years, 7 months ago (Feb. 1, 2006)
Published Print	19 years, 7 months ago (Feb. 1, 2006)

Funders 0

None

BibTeX

@article{Perry_2006, title={Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs}, volume={69}, ISSN={0026-895X}, url={http://dx.doi.org/10.1124/mol.105.016741}, DOI={10.1124/mol.105.016741}, number={2}, journal={Molecular Pharmacology}, publisher={Elsevier BV}, author={Perry, Matthew and Stansfeld, Phillip J. and Leaney, Joanne and Wood, Claire and de Groot, Marcel J. and Leishman, Derek and Sutcliffe, Michael J. and Mitcheson, John S.}, year={2006}, month=feb, pages={509–519} }

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