DOI: 10.1124/jpet.102.042325. Effects of Irbesartan on Cloned Potassium Channels Involved in Human Cardiac Repolarization

Effects of Irbesartan on Cloned Potassium Channels Involved in Human Cardiac Repolarization

10.1124/jpet.102.042325

Crossref journal-article

Elsevier BV

The Journal of Pharmacology and Experimental Therapeutics (78)

Bibliography

Moreno, I., Caballero, R., GonzÃ¡lez, T., Arias, C., Valenzuela, C., Iriepa, I., GÃ¡lvez, E., Tamargo, J., & DelpÃ³n, E. (2003). Effects of Irbesartan on Cloned Potassium Channels Involved in Human Cardiac Repolarization. The Journal of Pharmacology and Experimental Therapeutics, 304(2), 862â873.

Authors 9

Ignacio Moreno (first)
Ricardo Caballero (additional)
Teresa González (additional)
Cristina Arias (additional)
Carmen Valenzuela (additional)
Isabel Iriepa (additional)
Enrique Gálvez (additional)
Juan Tamargo (additional)
Eva Delpón (additional)

References 28 Referenced 46

10.1016/S0092-8674(00)80728-X / Cell / MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. by Abbott (1999)
10.1038/384078a0 / Nature (Lond) / KvLQT1 and IsK (minK) proteins associate to form the IKs cardiac potassium current. by Barhanin (1996)
10.1016/S0026-895X(24)09251-4 / Mol Pharmacol / Direct effects of candesartan and eprosartan on human cloned potassium channels involved in cardiac repolarization. by Caballero (2001)
10.1161/01.CIR.101.10.1199 / Circulation / Losartan and its metabolite E3174, modify cardiac delayed rectifier K+ currents. by Caballero (2000)
10.1016/S0008-6363(02)00509-6 / Cardiovasc Res / Putative binding site for benzocaine on a human cardiac cloned channel (Kv1.5). by Caballero (2002)
{'key': '10.1124/jpet.102.042325_bib6', 'first-page': 'II217', 'article-title': 'A critical role for S6 valines in the pharmacological properties of transient outward current (Ito) carried by Kv4.2 subunits.', 'volume': '104', 'author': 'Caballero', 'year': '2001', 'journal-title': 'Circulation'} / Circulation / A critical role for S6 valines in the pharmacological properties of transient outward current (Ito) carried by Kv4.2 subunits. by Caballero (2001)
10.1016/S0731-7085(01)00413-7 / J Pharm Biomed Anal / p Ka determination of angiotensin II receptor antagonists (ARA II) by spectrofluorometry. by Cagigal (2001)
10.1038/35002099 / Nature (Lond) / Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. by Del Camino (2000)
10.1126/science.280.5360.69 / Science (Wash DC) / The structure of the potassium channel: molecular basis of K+ conduction and selectivity. by Doyle (1998)
10.1161/01.RES.81.6.1053 / Circ Res / Molecular determinants of stereoselective bupivacaine block of hKv1.5 channels. by Franqueza (1997)
10.1161/01.HYP.33.2.713 / Hypertension / Irbesartan reduces QT dispersion in hypertensive individuals. by Lim (1999)
10.1161/01.CIR.0000022665.18619.83 / Circulation / Use of irbesartan to maintain sinus rhythm in patients with long-lasting persistent atrial fibrillation: a prospective and randomized study. by Madrid (2002)
10.2165/00003495-200059050-00014 / Drugs / Irbesartan: an update review of its use in cardiovascular disorders. by Markham (2000)
10.1073/pnas.210244497 / Proc Natl Acad Sci USA / A structural basis for drug-induced long QT syndrome. by Mitcheson (2000)
10.1016/S1093-3263(02)00127-4 / J Mol Graph Model / Ligand-receptor interaction at the neural nicotinic acetylcholine binding site: a theoretical model. by Morreale (2002)
10.1111/j.1469-7793.2000.t01-1-00285.x / J Physiol (Lond) / Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium. by Nerbonne (2000)
10.1152/ajpcell.00232.2001 / Am J Physiol / Mutations throughout the S6 region of the hKv1.5 channel alter the stability of the activation gate. by Rich (2002)
10.1111/j.1469-7793.2001.0119b.x / J Physiol (Lond) / Regulation of KChIP2 potassium channel. by Rosati (2001)
10.1074/jbc.M200448200 / J Biol Chem / Molecular determinants of voltage dependent HERG K+ channel block. by Sánchez-Chapula (2002)
10.1038/384080a0 / Nature (Lond) / Coassembly of KvLQT1 and minK (IsK) proteins to form cardiac IKs potassium channel. by Sanguinetti (1996)
10.1016/0092-8674(95)90340-2 / Cell / A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. by Sanguinetti (1995)
10.1006/jmcc.2000.1317 / J Mol Cell Cardiol / IKr: the HERG channel. by Tseng (2001)
10.1161/01.RES.73.6.1061 / Circ Res / Sustained depolarization-induced outward current in human atrial myocytes: evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channels currents. by Wang (1993)
10.1161/01.RES.84.5.551 / Circ Res / The potential molecular basis of different physiological properties of transient outward K+ current in rabbit and human atrial myocytes. by Wang (1999)
10.1016/S0031-6997(25)07122-4 / Pharmacol Rev / Pharmacological receptors. by Waud (1968)
10.1113/jphysiol.2001.013296 / J Physiol (Lond) / A comparison of currents carried by HERG, with and without coexpression of MiRP1 and the native rapid delayed rectifier current. Is MiRP1 the missing link? by Weerapura (2002)
10.1161/01.RES.78.6.1105 / Circ Res / Molecular analysis of a binding site for quinidine in a human cardiac delayed rectifier K+ channel. Role of S6 in antiarrhythmic drug binding. by Yeola (1996)
10.1016/S0022-3565(24)37795-X / J Pharmacol Exp Ther / Differential effects of S6 mutations on binding of quinidine and 4-aminopyridine to rat isoform of Kv1.4: common site but different factors in determining blockers’ binding affinity. by Zhang (1998)

Dates

Type	When
Created	22 years, 7 months ago (Jan. 21, 2003, 7:25 p.m.)
Deposited	6 months, 2 weeks ago (Feb. 19, 2025, 6:38 p.m.)
Indexed	1 month, 4 weeks ago (July 6, 2025, 1:44 p.m.)
Issued	22 years, 7 months ago (Feb. 1, 2003)
Published	22 years, 7 months ago (Feb. 1, 2003)
Published Print	22 years, 7 months ago (Feb. 1, 2003)

Funders 0

None

BibTeX

@article{Moreno_2003, title={Effects of Irbesartan on Cloned Potassium Channels Involved in Human Cardiac Repolarization}, volume={304}, ISSN={0022-3565}, url={http://dx.doi.org/10.1124/jpet.102.042325}, DOI={10.1124/jpet.102.042325}, number={2}, journal={The Journal of Pharmacology and Experimental Therapeutics}, publisher={Elsevier BV}, author={Moreno, Ignacio and Caballero, Ricardo and González, Teresa and Arias, Cristina and Valenzuela, Carmen and Iriepa, Isabel and Gálvez, Enrique and Tamargo, Juan and Delpón, Eva}, year={2003}, month=feb, pages={862–873} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        6
      ]
    ],
    "date-time": "2025-07-06T17:44:06Z",
    "timestamp": 1751823846891,
    "version": "3.37.3"
  },
  "reference-count": 28,
  "publisher": "Elsevier BV",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2003,
            2,
            1
          ]
        ],
        "date-time": "2003-02-01T00:00:00Z",
        "timestamp": 1044057600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2003,
            2,
            1
          ]
        ],
        "date-time": "2003-02-01T00:00:00Z",
        "timestamp": 1044057600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/legal/tdmrep-license"
    }
  ],
  "content-domain": {
    "domain": [
      "jpet.aspetjournals.org",
      "elsevier.com",
      "sciencedirect.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2003,
        2
      ]
    ]
  },
  "DOI": "10.1124/jpet.102.042325",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        1,
        22
      ]
    ],
    "date-time": "2003-01-22T00:25:12Z",
    "timestamp": 1043195112000
  },
  "page": "862-873",
  "update-policy": "https://doi.org/10.1016/elsevier_cm_policy",
  "source": "Crossref",
  "is-referenced-by-count": 46,
  "title": "Effects of Irbesartan on Cloned Potassium Channels Involved in Human Cardiac Repolarization",
  "prefix": "10.1016",
  "volume": "304",
  "author": [
    {
      "given": "Ignacio",
      "family": "Moreno",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Ricardo",
      "family": "Caballero",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Teresa",
      "family": "Gonz\u00e1lez",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Cristina",
      "family": "Arias",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Carmen",
      "family": "Valenzuela",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Isabel",
      "family": "Iriepa",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Enrique",
      "family": "G\u00e1lvez",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Juan",
      "family": "Tamargo",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Eva",
      "family": "Delp\u00f3n",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1124/jpet.102.042325_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "175",
      "DOI": "10.1016/S0092-8674(00)80728-X",
      "article-title": "MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia.",
      "volume": "97",
      "author": "Abbott",
      "year": "1999",
      "journal-title": "Cell"
    },
    {
      "key": "10.1124/jpet.102.042325_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "78",
      "DOI": "10.1038/384078a0",
      "article-title": "KvLQT1 and IsK (minK) proteins associate to form the IKs cardiac potassium current.",
      "volume": "384",
      "author": "Barhanin",
      "year": "1996",
      "journal-title": "Nature (Lond)"
    },
    {
      "key": "10.1124/jpet.102.042325_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "825",
      "DOI": "10.1016/S0026-895X(24)09251-4",
      "article-title": "Direct effects of candesartan and eprosartan on human cloned potassium channels involved in cardiac repolarization.",
      "volume": "59",
      "author": "Caballero",
      "year": "2001",
      "journal-title": "Mol Pharmacol"
    },
    {
      "key": "10.1124/jpet.102.042325_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "1199",
      "DOI": "10.1161/01.CIR.101.10.1199",
      "article-title": "Losartan and its metabolite E3174, modify cardiac delayed rectifier K+ currents.",
      "volume": "101",
      "author": "Caballero",
      "year": "2000",
      "journal-title": "Circulation"
    },
    {
      "key": "10.1124/jpet.102.042325_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "104",
      "DOI": "10.1016/S0008-6363(02)00509-6",
      "article-title": "Putative binding site for benzocaine on a human cardiac cloned channel (Kv1.5).",
      "volume": "56",
      "author": "Caballero",
      "year": "2002",
      "journal-title": "Cardiovasc Res"
    },
    {
      "key": "10.1124/jpet.102.042325_bib6",
      "first-page": "II217",
      "article-title": "A critical role for S6 valines in the pharmacological properties of transient outward current (Ito) carried by Kv4.2 subunits.",
      "volume": "104",
      "author": "Caballero",
      "year": "2001",
      "journal-title": "Circulation"
    },
    {
      "key": "10.1124/jpet.102.042325_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "477",
      "DOI": "10.1016/S0731-7085(01)00413-7",
      "article-title": "p Ka determination of angiotensin II receptor antagonists (ARA II) by spectrofluorometry.",
      "volume": "26",
      "author": "Cagigal",
      "year": "2001",
      "journal-title": "J Pharm Biomed Anal"
    },
    {
      "key": "10.1124/jpet.102.042325_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "321",
      "DOI": "10.1038/35002099",
      "article-title": "Blocker protection in the pore of a voltage-gated K+ channel and its structural implications.",
      "volume": "403",
      "author": "Del Camino",
      "year": "2000",
      "journal-title": "Nature (Lond)"
    },
    {
      "key": "10.1124/jpet.102.042325_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "69",
      "DOI": "10.1126/science.280.5360.69",
      "article-title": "The structure of the potassium channel: molecular basis of K+ conduction and selectivity.",
      "volume": "280",
      "author": "Doyle",
      "year": "1998",
      "journal-title": "Science (Wash DC)"
    },
    {
      "key": "10.1124/jpet.102.042325_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "1053",
      "DOI": "10.1161/01.RES.81.6.1053",
      "article-title": "Molecular determinants of stereoselective bupivacaine block of hKv1.5 channels.",
      "volume": "81",
      "author": "Franqueza",
      "year": "1997",
      "journal-title": "Circ Res"
    },
    {
      "key": "10.1124/jpet.102.042325_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "713",
      "DOI": "10.1161/01.HYP.33.2.713",
      "article-title": "Irbesartan reduces QT dispersion in hypertensive individuals.",
      "volume": "33",
      "author": "Lim",
      "year": "1999",
      "journal-title": "Hypertension"
    },
    {
      "key": "10.1124/jpet.102.042325_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "331",
      "DOI": "10.1161/01.CIR.0000022665.18619.83",
      "article-title": "Use of irbesartan to maintain sinus rhythm in patients with long-lasting persistent atrial fibrillation: a prospective and randomized study.",
      "volume": "106",
      "author": "Madrid",
      "year": "2002",
      "journal-title": "Circulation"
    },
    {
      "key": "10.1124/jpet.102.042325_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "23",
      "DOI": "10.2165/00003495-200059050-00014",
      "article-title": "Irbesartan: an update review of its use in cardiovascular disorders.",
      "volume": "59",
      "author": "Markham",
      "year": "2000",
      "journal-title": "Drugs"
    },
    {
      "key": "10.1124/jpet.102.042325_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "12329",
      "DOI": "10.1073/pnas.210244497",
      "article-title": "A structural basis for drug-induced long QT syndrome.",
      "volume": "97",
      "author": "Mitcheson",
      "year": "2000",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1124/jpet.102.042325_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "111",
      "DOI": "10.1016/S1093-3263(02)00127-4",
      "article-title": "Ligand-receptor interaction at the neural nicotinic acetylcholine binding site: a theoretical model.",
      "volume": "21",
      "author": "Morreale",
      "year": "2002",
      "journal-title": "J Mol Graph Model"
    },
    {
      "key": "10.1124/jpet.102.042325_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "285",
      "DOI": "10.1111/j.1469-7793.2000.t01-1-00285.x",
      "article-title": "Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium.",
      "volume": "525",
      "author": "Nerbonne",
      "year": "2000",
      "journal-title": "J Physiol (Lond)"
    },
    {
      "key": "10.1124/jpet.102.042325_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "C161",
      "DOI": "10.1152/ajpcell.00232.2001",
      "article-title": "Mutations throughout the S6 region of the hKv1.5 channel alter the stability of the activation gate.",
      "volume": "282",
      "author": "Rich",
      "year": "2002",
      "journal-title": "Am J Physiol"
    },
    {
      "key": "10.1124/jpet.102.042325_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "119",
      "DOI": "10.1111/j.1469-7793.2001.0119b.x",
      "article-title": "Regulation of KChIP2 potassium channel.",
      "volume": "533",
      "author": "Rosati",
      "year": "2001",
      "journal-title": "J Physiol (Lond)"
    },
    {
      "key": "10.1124/jpet.102.042325_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "23587",
      "DOI": "10.1074/jbc.M200448200",
      "article-title": "Molecular determinants of voltage dependent HERG K+ channel block.",
      "volume": "277",
      "author": "S\u00e1nchez-Chapula",
      "year": "2002",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1124/jpet.102.042325_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "80",
      "DOI": "10.1038/384080a0",
      "article-title": "Coassembly of KvLQT1 and minK (IsK) proteins to form cardiac IKs potassium channel.",
      "volume": "384",
      "author": "Sanguinetti",
      "year": "1996",
      "journal-title": "Nature (Lond)"
    },
    {
      "key": "10.1124/jpet.102.042325_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "299",
      "DOI": "10.1016/0092-8674(95)90340-2",
      "article-title": "A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel.",
      "volume": "81",
      "author": "Sanguinetti",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1124/jpet.102.042325_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "835",
      "DOI": "10.1006/jmcc.2000.1317",
      "article-title": "IKr: the HERG channel.",
      "volume": "33",
      "author": "Tseng",
      "year": "2001",
      "journal-title": "J Mol Cell Cardiol"
    },
    {
      "key": "10.1124/jpet.102.042325_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "1061",
      "DOI": "10.1161/01.RES.73.6.1061",
      "article-title": "Sustained depolarization-induced outward current in human atrial myocytes: evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channels currents.",
      "volume": "73",
      "author": "Wang",
      "year": "1993",
      "journal-title": "Circ Res"
    },
    {
      "key": "10.1124/jpet.102.042325_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "551",
      "DOI": "10.1161/01.RES.84.5.551",
      "article-title": "The potential molecular basis of different physiological properties of transient outward K+ current in rabbit and human atrial myocytes.",
      "volume": "84",
      "author": "Wang",
      "year": "1999",
      "journal-title": "Circ Res"
    },
    {
      "key": "10.1124/jpet.102.042325_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "49",
      "DOI": "10.1016/S0031-6997(25)07122-4",
      "article-title": "Pharmacological receptors.",
      "volume": "20",
      "author": "Waud",
      "year": "1968",
      "journal-title": "Pharmacol Rev"
    },
    {
      "key": "10.1124/jpet.102.042325_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "15",
      "DOI": "10.1113/jphysiol.2001.013296",
      "article-title": "A comparison of currents carried by HERG, with and without coexpression of MiRP1 and the native rapid delayed rectifier current. Is MiRP1 the missing link?",
      "volume": "540",
      "author": "Weerapura",
      "year": "2002",
      "journal-title": "J Physiol (Lond)"
    },
    {
      "key": "10.1124/jpet.102.042325_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "1105",
      "DOI": "10.1161/01.RES.78.6.1105",
      "article-title": "Molecular analysis of a binding site for quinidine in a human cardiac delayed rectifier K+ channel. Role of S6 in antiarrhythmic drug binding.",
      "volume": "78",
      "author": "Yeola",
      "year": "1996",
      "journal-title": "Circ Res"
    },
    {
      "key": "10.1124/jpet.102.042325_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "332",
      "DOI": "10.1016/S0022-3565(24)37795-X",
      "article-title": "Differential effects of S6 mutations on binding of quinidine and 4-aminopyridine to rat isoform of Kv1.4: common site but different factors in determining blockers\u2019 binding affinity.",
      "volume": "287",
      "author": "Zhang",
      "year": "1998",
      "journal-title": "J Pharmacol Exp Ther"
    }
  ],
  "container-title": "The Journal of Pharmacology and Experimental Therapeutics",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0022356524361804?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0022356524361804?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://syndication.highwire.org/content/doi/10.1124/jpet.102.042325",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2025,
        2,
        19
      ]
    ],
    "date-time": "2025-02-19T23:38:37Z",
    "timestamp": 1740008317000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0022356524361804"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2003,
        2
      ]
    ]
  },
  "references-count": 28,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          2003,
          2
        ]
      ]
    }
  },
  "alternative-id": [
    "S0022356524361804"
  ],
  "URL": "http://dx.doi.org/10.1124/jpet.102.042325",
  "relation": {},
  "ISSN": [
    "0022-3565"
  ],
  "subject": [],
  "container-title-short": "The Journal of Pharmacology and Experimental Therapeutics",
  "published": {
    "date-parts": [
      [
        2003,
        2
      ]
    ]
  },
  "assertion": [
    {
      "value": "Elsevier",
      "name": "publisher",
      "label": "This article is maintained by"
    },
    {
      "value": "Effects of Irbesartan on Cloned Potassium Channels Involved in Human Cardiac Repolarization",
      "name": "articletitle",
      "label": "Article Title"
    },
    {
      "value": "The Journal of Pharmacology and Experimental Therapeutics",
      "name": "journaltitle",
      "label": "Journal Title"
    },
    {
      "value": "https://doi.org/10.1124/jpet.102.042325",
      "name": "articlelink",
      "label": "CrossRef DOI link to publisher maintained version"
    },
    {
      "value": "article",
      "name": "content_type",
      "label": "Content Type"
    },
    {
      "value": "\u00a9 2003 The American Society for Pharmacology and Experimental Therapeutics",
      "name": "copyright",
      "label": "Copyright"
    }
  ]
}