DOI: 10.1118/1.3525837. Large breast compressions: Observations and evaluation of simulations

Large breast compressions: Observations and evaluation of simulations

10.1118/1.3525837

Crossref journal-article

Wiley

Medical Physics (311)

Abstract

Purpose:Several methods have been proposed to simulate large breast compressions such as those occurring during x‐ray mammography. However, the evaluation of these methods against real data is rare. The aim of this study is to learn more about the deformation behavior of breasts and to assess a simulation method.Methods:Magnetic resonance (MR) images of 11 breasts before and after applying a relatively largein vivo compression in the medial direction were acquired. Nonrigid registration was employed to study the deformation behavior. Optimal material properties for finite element modeling were determined and their prediction performance was assessed. The realism of simulated compressions was evaluated by comparing the breast shapes on simulated and real mammograms.Results:Following image registration, 19 breast compressions from 8 women were studied. An anisotropic deformation behavior, with a reduced elongation in the anterior‐posterior direction and an increased stretch in the inferior‐superior direction was observed. Using finite element simulations, the performance of isotropic and transverse isotropic material models to predict the displacement of internal landmarks was compared. Isotropic materials reduced the mean displacement error of the landmarks from 23.3 to 4.7 mm, on average, after optimizing material properties with respect to breast surface alignment and image similarity. Statistically significantly smaller errors were achieved with transverse isotropic materials (4.1 mm,). Homogeneous material models performed substantially worse (transverse isotropic: 5.5 mm; isotropic: 6.7 mm). Of the parameters varied, the amount of anisotropy had the greatest influence on the results. Optimal material properties varied less when grouped by patient rather than by compression magnitude (mean: 0.72 vs 1.44). Employing these optimal materials for simulating mammograms from ten MR breast images of a different cohort resulted in more realistic breast shapes than when using established material models.Conclusions:Breasts in the prone position exhibited an anisotropic compression behavior. Transverse isotropic materials with an increased stiffness in the anterior‐posterior direction improved the prediction of these deformations and produced more realistic mammogram simulations from MR images.

Bibliography

Tanner, C., White, M., Guarino, S., HallâCraggs, M. A., Douek, M., & Hawkes, D. J. (2011). Large breast compressions: Observations and evaluation of simulations. Medical Physics, 38(2), 682â690. Portico.

Authors 6

Christine Tanner (first)
Mark White (additional)
Salvatore Guarino (additional)
Margaret A. Hall‐Craggs (additional)
Michael Douek (additional)
David J. Hawkes (additional)

References 31 Referenced 24

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N. V. Ruiter 2003 Universität Mannheim
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{'key': 'e_1_2_8_5_1', 'volume-title': 'Proceedings of MICCAI', 'author': 'Pathmanathan P.', 'year': '2004'} / Proceedings of MICCAI by Pathmanathan P. (2004)
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P. S. Wellman 1999 Harvard University
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Dates

Type	When
Created	14 years, 6 months ago (Feb. 2, 2011, 6:28 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 3:39 a.m.)
Indexed	6 days, 11 hours ago (Aug. 23, 2025, 9:38 p.m.)
Issued	14 years, 7 months ago (Jan. 10, 2011)
Published	14 years, 7 months ago (Jan. 10, 2011)
Published Online	14 years, 7 months ago (Jan. 10, 2011)
Published Print	14 years, 6 months ago (Feb. 1, 2011)

Funders 2

Engineering and Physical Sciences Research Council 10.13039/501100000266
Region: Europe
gov (National government)
Labels4
1. UKRI Engineering and Physical Sciences Research Council
2. Engineering and Physical Sciences Research Council - UKRI
3. Engineering & Physical Sciences Research Council
4. EPSRC
Awards1
1. EP/E031579/1
Technology Strategy Board 10.13039/501100000396
Region: Europe
pri (For-profit companies (industry))
Labels1
1. TSB
Awards1
1. TP/3/IMG/6/I/15558

BibTeX

@article{Tanner_2011, title={Large breast compressions: Observations and evaluation of simulations}, volume={38}, ISSN={2473-4209}, url={http://dx.doi.org/10.1118/1.3525837}, DOI={10.1118/1.3525837}, number={2}, journal={Medical Physics}, publisher={Wiley}, author={Tanner, Christine and White, Mark and Guarino, Salvatore and Hall‐Craggs, Margaret A. and Douek, Michael and Hawkes, David J.}, year={2011}, month=jan, pages={682–690} }

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