DOI: 10.1115/1.3108402. Passive Deformation Analysis of Human Leukocytes

Passive Deformation Analysis of Human Leukocytes

10.1115/1.3108402

Crossref journal-article

ASME International

Journal of Biomechanical Engineering (33)

Abstract

The following analysis presents an experimental and theoretical study of the passive viscoelastic behavior of human leukocytes. Individual neutrophils in EDTA were observed both during their partial aspiration into a small micropipette and after expulsion from a large micropipette where the cell had been totally aspirated and deformed into a sausage shape. To analyze the data, a passive model of leukocyte rheology has been developed consisting of a cortical shell containing a Maxwell fluid which describes the average properties of the cell cytoplasm. The cortical shell represents a crosslinked actin layer near the surface of the cell and is assumed to be under pre-stressed tension. This model can reproduce the results of experiments using micropipette for both short-time small deformation and slow recovery data after large deformation. In addition, a finite element scheme has been established for the same model which shows close agreement with the analytical solution.

Bibliography

Dong, C., Skalak, R., Sung, K.-L. P., Schmid-SchoÂ¨nbein, G. W., & Chien, S. (1988). Passive Deformation Analysis of Human Leukocytes. Journal of Biomechanical Engineering, 110(1), 27â36.

Authors 5

Cheng Dong (first)
R. Skalak (additional)
Kuo-Li Paul Sung (additional)
G. W. Schmid-Scho¨nbein (additional)
Shu Chien (additional)

References 0 Referenced 140

None

Dates

Type	When
Created	16 years, 2 months ago (June 12, 2009, 6:34 p.m.)
Deposited	5 years, 11 months ago (Oct. 4, 2019, 6:48 a.m.)
Indexed	2 months ago (July 2, 2025, 2:33 p.m.)
Issued	37 years, 7 months ago (Feb. 1, 1988)
Published	37 years, 7 months ago (Feb. 1, 1988)
Published Online	37 years, 7 months ago (Feb. 1, 1988)
Published Print	37 years, 7 months ago (Feb. 1, 1988)

Funders 0

None

BibTeX

@article{Dong_1988, title={Passive Deformation Analysis of Human Leukocytes}, volume={110}, ISSN={1528-8951}, url={http://dx.doi.org/10.1115/1.3108402}, DOI={10.1115/1.3108402}, number={1}, journal={Journal of Biomechanical Engineering}, publisher={ASME International}, author={Dong, Cheng and Skalak, R. and Sung, Kuo-Li Paul and Schmid-Scho¨nbein, G. W. and Chien, Shu}, year={1988}, month=feb, pages={27–36} }

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