DOI: 10.1113/jphysiol.2007.148098. LTP of GABAergic synapses in the ventral tegmental area and beyond

LTP of GABAergic synapses in the ventral tegmental area and beyond

10.1113/jphysiol.2007.148098

Crossref journal-article

Wiley

The Journal of Physiology (311)

Abstract

One of the mechanisms by which the experience‐dependent reorganization of neural circuitry can occur is through changes in synaptic strength. Almost every excitatory synapse in the mammalian brain exhibits LTP (long‐term potentiation) or LTD (long‐term depression), two cellular mechanisms of synaptic plasticity. However, LTP and LTD have been reported much more rarely at fast inhibitory GABAA receptor synapses. Our recent study suggests that in vivo morphine initiates a long‐lasting alteration of GABAergic synapses in the ventral tegmental area (VTA) by blocking the mechanisms required for LTP of GABAergic synapses. Here we put this work into the context of other examples of synaptic plasticity at GABAergic synapses.

Bibliography

Nugent, F. S., & Kauer, J. A. (2008). LTP of GABAergic synapses in the ventral tegmental area and beyond. The Journal of Physiology, 586(6), 1487â1493. Portico.

Authors 2

Fereshteh S. Nugent (first)
Julie A. Kauer (additional)

References 60 Referenced 66

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Dates

Type	When
Created	17 years, 8 months ago (Dec. 13, 2007, 8:34 p.m.)
Deposited	1 year, 10 months ago (Oct. 11, 2023, 3:43 p.m.)
Indexed	2 days, 6 hours ago (Aug. 28, 2025, 8:32 a.m.)
Issued	17 years, 5 months ago (March 15, 2008)
Published	17 years, 5 months ago (March 15, 2008)
Published Online	17 years, 5 months ago (March 17, 2008)
Published Print	17 years, 5 months ago (March 15, 2008)

Funders 0

None

BibTeX

@article{Nugent_2008, title={LTP of GABAergic synapses in the ventral tegmental area and beyond}, volume={586}, ISSN={1469-7793}, url={http://dx.doi.org/10.1113/jphysiol.2007.148098}, DOI={10.1113/jphysiol.2007.148098}, number={6}, journal={The Journal of Physiology}, publisher={Wiley}, author={Nugent, Fereshteh S. and Kauer, Julie A.}, year={2008}, month=mar, pages={1487–1493} }

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