DOI: 10.1113/jphysiol.2005.102889. Calcium‐sensing mechanism in TRPC5 channels contributing to retardation of neurite outgrowth

Calcium‐sensing mechanism in TRPC5 channels contributing to retardation of neurite outgrowth

10.1113/jphysiol.2005.102889

Crossref journal-article

Wiley

The Journal of Physiology (311)

Abstract

The calcium‐ and sodium‐permeable transient receptor potential channel TRPC5 has an inhibitory role in neuronal outgrowth but the mechanisms governing its activity are poorly understood. Here we propose a mechanism involving the neuronal calcium sensor‐1 (NCS‐1) protein. Inhibitory mutants of TRPC5 and NCS‐1 enhance neurite outgrowth similarly. Mutant NCS‐1 does not inhibit surface‐expression of TRPC5 but generally suppresses channel activity, irrespective of whether it is evoked by carbachol, store depletion, lanthanides or elevated intracellular calcium. NCS‐1 and TRPC5 are in the same protein complex in rat brain and NCS‐1 directly binds to the TRPC5 C‐terminus. The data suggest protein–protein interaction between NCS‐1 and TRPC5, and involvement of this protein complex in retardation of neurite outgrowth.

Bibliography

Hui, H., McHugh, D., Hannan, M., Zeng, F., Xu, S., Khan, S., Levenson, R., Beech, D. J., & Weiss, J. L. (2006). Calciumâsensing mechanism in TRPC5 channels contributing to retardation of neurite outgrowth. The Journal of Physiology, 572(1), 165â172. Portico.

Authors 9

Hui Hui (first)
Damian McHugh (additional)
Meredith Hannan (additional)
Fanning Zeng (additional)
Shang‐Zhong Xu (additional)
Saeed‐ul‐Hassan Khan (additional)
Robert Levenson (additional)
David J. Beech (additional)
Jamie L. Weiss (additional)

References 31 Referenced 87

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{'key': 'e_1_2_5_11_1', 'article-title': 'Involvement of calmodulin and myosin light chain kinase in the activation of mTRPC5 expressed in HEK cells', 'author': 'Kim MT', 'year': '2006', 'journal-title': 'Am J Physiol Cell Physiol'} / Am J Physiol Cell Physiol / Involvement of calmodulin and myosin light chain kinase in the activation of mTRPC5 expressed in HEK cells by Kim MT (2006)
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{'key': 'e_1_2_5_21_1', 'article-title': 'An introduction to TRP channels', 'author': 'Ramsey IS', 'year': '2006', 'journal-title': 'Annu Rev Physiol'} / Annu Rev Physiol / An introduction to TRP channels by Ramsey IS (2006)
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Dates

Type	When
Created	19 years, 6 months ago (Feb. 9, 2006, 8:24 p.m.)
Deposited	1 year, 10 months ago (Oct. 11, 2023, 8:43 a.m.)
Indexed	1 month, 1 week ago (July 16, 2025, 9:16 a.m.)
Issued	19 years, 4 months ago (March 28, 2006)
Published	19 years, 4 months ago (March 28, 2006)
Published Online	19 years, 4 months ago (March 28, 2006)
Published Print	19 years, 4 months ago (April 1, 2006)

Funders 0

None

BibTeX

@article{Hui_2006, title={Calcium‐sensing mechanism in TRPC5 channels contributing to retardation of neurite outgrowth}, volume={572}, ISSN={1469-7793}, url={http://dx.doi.org/10.1113/jphysiol.2005.102889}, DOI={10.1113/jphysiol.2005.102889}, number={1}, journal={The Journal of Physiology}, publisher={Wiley}, author={Hui, Hui and McHugh, Damian and Hannan, Meredith and Zeng, Fanning and Xu, Shang‐Zhong and Khan, Saeed‐ul‐Hassan and Levenson, Robert and Beech, David J. and Weiss, Jamie L.}, year={2006}, month=mar, pages={165–172} }

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