DOI: 10.1113/jphysiol.2005.084384. β‐Adrenoceptor‐mediated long‐term up‐regulation of the release machinery at rat cerebellar GABAergic synapses

β‐Adrenoceptor‐mediated long‐term up‐regulation of the release machinery at rat cerebellar GABAergic synapses

10.1113/jphysiol.2005.084384

Crossref journal-article

Wiley

The Journal of Physiology (311)

Abstract

Properly regulated interactions among excitatory and inhibitory synapses are critical for brain function. Compared to excitatory synapses, much less is known about the gain control mechanisms at inhibitory synapses. Herein we report a mechanism of noradrenergic long‐term potentiation (LTP) at inhibitory synapses following presynaptic β‐adrenoceptor activation. Stimulation of β‐adrenoceptors elicited LTP of GABA release from terminals of cerebellar interneurones. This action was dependent on the cAMP/protein kinase A signalling cascade and independent of the β‐adrenoceptor‐mediated acceleration of hyperpolarization‐activated cyclic nucleotide‐gated cation (HCN) channel. Furthermore, the β‐adrenoceptor‐ and protein kinase A‐mediated LTP was triggered by enhancement of the Ca2+ sensitivity of the release machinery and increase in the readily releasable pool. β‐Adrenoceptor activation also accelerated the recruitment of GABA into the releasable pool and enhanced synchronous and asynchronous release of GABA from the presynaptic terminal. Thus, the up‐regulation of GABA release machinery mediated by noradrenaline and β‐adrenoceptor activation provides a likely mechanism of feedforward inhibition of the cerebellar output neurone Purkinje cell, leading to a profound effect on motor control and learning associated with the cerebellum.

Authors 3

Fumihito Saitow (first)
Hidenori Suzuki (additional)
Shiro Konishi (additional)

References 42 Referenced 28

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{'key': 'e_1_2_5_37_1', 'first-page': '15', 'article-title': 'Roles of Ih in β‐adrenergic receptor‐mediated enhancement of inhibitory transmission at cerebellar basket cell‐Purkinje cell synapses', 'volume': '837', 'author': 'Saitow F', 'year': '2002', 'journal-title': 'Soc Neurosci Abstr'} / Soc Neurosci Abstr / Roles of Ih in β‐adrenergic receptor‐mediated enhancement of inhibitory transmission at cerebellar basket cell‐Purkinje cell synapses by Saitow F (2002)
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Dates

Type	When
Created	20 years, 5 months ago (March 24, 2005, 8:24 p.m.)
Deposited	1 year, 10 months ago (Oct. 13, 2023, 11:28 p.m.)
Indexed	3 days ago (Aug. 29, 2025, 5:40 a.m.)
Issued	20 years, 3 months ago (June 1, 2005)
Published	20 years, 3 months ago (June 1, 2005)
Published Online	20 years, 2 months ago (June 13, 2005)
Published Print	20 years, 3 months ago (June 1, 2005)

Funders 0

None

BibTeX

@article{Saitow_2005, title={β‐Adrenoceptor‐mediated long‐term up‐regulation of the release machinery at rat cerebellar GABAergic synapses}, volume={565}, ISSN={1469-7793}, url={http://dx.doi.org/10.1113/jphysiol.2005.084384}, DOI={10.1113/jphysiol.2005.084384}, number={2}, journal={The Journal of Physiology}, publisher={Wiley}, author={Saitow, Fumihito and Suzuki, Hidenori and Konishi, Shiro}, year={2005}, month=jun, pages={487–502} }

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