DOI: 10.1113/jphysiol.1973.sp010306. Cortical pyramidal tract interneurones and their sensitivity to L‐glutamic acid

Cortical pyramidal tract interneurones and their sensitivity to L‐glutamic acid

10.1113/jphysiol.1973.sp010306

Crossref journal-article

Wiley

The Journal of Physiology (311)

Abstract

1. Pyramidal tract interneurones, defined as neurones which are activated synaptically as a result of pyramidal tract stimulation, have been identified in the rat cerebral cortex. The number of evoked spikes depended upon stimulus strength, and stimulation in a specific thalamic nucleus produced a burst of activity lasting for up to 1 sec.2. These cells are readily excited by a brief (50 msec) pulse of glutamate applied by micro‐iontophoresis. Other, unidentified cells are not so responsive.3. Synaptically evoked spikes resulting from pyramidal tract stimulation can be blocked by the iontophoretic and I.P. administration of substances shown to antagonize glutamate excitation of cells.4. The results support suggestions that glutamic acid is a neurotransmitter in the cerebral cortex. The evidence presented further indicates that glutamic acid could be the transmitter released by the pyramidal tract.

Bibliography

Stone, T. W. (1973). Cortical pyramidal tract interneurones and their sensitivity to Lâglutamic acid. The Journal of Physiology, 233(1), 211â225. Portico.

Authors 1

T. W. Stone (first)

References 0 Referenced 80

None

Dates

Type	When
Created	10 years, 8 months ago (Dec. 19, 2014, 5:26 a.m.)
Deposited	1 year, 9 months ago (Nov. 8, 2023, 3:39 p.m.)
Indexed	1 year, 7 months ago (Jan. 13, 2024, 4:30 a.m.)
Issued	52 years ago (Aug. 1, 1973)
Published	52 years ago (Aug. 1, 1973)
Published Online	52 years ago (Aug. 1, 1973)
Published Print	52 years ago (Aug. 1, 1973)

Funders 0

None

BibTeX

@article{Stone_1973, title={Cortical pyramidal tract interneurones and their sensitivity to L‐glutamic acid}, volume={233}, ISSN={1469-7793}, url={http://dx.doi.org/10.1113/jphysiol.1973.sp010306}, DOI={10.1113/jphysiol.1973.sp010306}, number={1}, journal={The Journal of Physiology}, publisher={Wiley}, author={Stone, T. W.}, year={1973}, month=aug, pages={211–225} }

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