DOI: 10.1111/j.2042-7158.1979.tb13508.x. Hypothermic effects of apomorphine homologues in mice

Hypothermic effects of apomorphine homologues in mice

10.1111/j.2042-7158.1979.tb13508.x

Crossref journal-article

Oxford University Press (OUP)

Journal of Pharmacy and Pharmacology (286)

Abstract

AbstractA single intraperitoneal (i.p.) injection in mice of apomorphine (I) and its analogues norapomorphine (II), N-ethylnorapomorphine (III), N-n-propylnorapomorphine (IV) and apocodeine (V), caused dose-related decreases in deep-core body temperature. The neuroleptic agent haloperidol blocked the hypothermia produced by these apomorphines but α-methyl-p-tyrosine failed to do so. This indicated a direct post-synaptic stimulation of dopamine receptors. Methysergide potentiated the hypothermic effect of the apomorphine analogues. Taking the amount of apomorphine to produce a 3 °C fall in temperature at 30 min as unity, the approximate relative potencies were: I 1.00, II 0.06, III 47.50, IV 85.00, V 0.340. The doses of the apomorphines needed to produce hypothermia were much less than those needed to cause stereotypy. The ratios of the minimal doses required to produce hypothermia, to those producing stereotypy were: I 8.82, II 4.00, III 125.00, IV 28.50, V 1.43.

Bibliography

Menon, M. K., Clark, W. G., & Cannon, J. G. (1979). Hypothermic effects of apomorphine homologues in mice. Journal of Pharmacy and Pharmacology, 31(1), 318â321.

Authors 3

M K Menon (first)
W G Clark (additional)
J G Cannon (additional)

References 21 Referenced 10

10.1021/jm00244a010 / J. Med. Chem. by Atkinson (1975)
{'key': '2024110403081046400_cit2', 'first-page': '242', 'volume': '198', 'author': 'Barnett', 'year': '1972', 'journal-title': 'Arch. Int. Pharmacodyn. Ther.'} / Arch. Int. Pharmacodyn. Ther. by Barnett (1972)
10.1038/264564a0 / Nature by Chiara (1976)
10.1016/S0074-7742(08)60705-9 / Int. Rev. Neurobiol. by Colpaert (1976)
10.1007/BF00421135 / Psychopharmacologia by Cools (1976)
10.1111/j.1476-5381.1977.tb09742.x / Br. J. Pharmacol. by Cox (1977)
10.1007/BF01897450 / Experientia by Ernst (1966)
10.1007/BF00403900 / Psychopharmacologia by Ernst (1967)
10.1111/j.2042-7158.1972.tb09093.x / J. Pharm. Pharmacol. by Fuxe (1972)
10.1016/S0031-6997(25)06902-9 / Pharmacol. Rev. by Goldberg (1972)
10.1016/0014-2999(73)90247-1 / Eur. J. Pharmacol. by Grabowska (1973)
{'key': '2024110403081046400_cit12', 'first-page': '269P', 'volume': '60', 'author': 'Koc', 'year': '1977', 'journal-title': 'Br. J. Pharmacol.'} / Br. J. Pharmacol. by Koc (1977)
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10.1111/j.2042-7158.1976.tb04050.x / J. Pharm. Pharmacol. by Menon (1976)
10.1021/jm00269a601 / J. Med. Chem. by Neumeyer (1973)
10.1111/j.2042-7158.1978.tb13176.x / J. Pharm. Pharmacol. by Pearl (1978)
10.1021/jm00256a013 / J. Med. Chem. by Saari (1974)
10.1007/BF00421801 / Psychopharmacology by Scheel-Krüger (1974)
10.1007/BF00432822 / Psychopharmacology by Schelkunov (1977)
10.1073/pnas.75.3.1153 / Proc. Natl. Acad. Sci. by Titeler (1978)

Dates

Type	When
Created	14 years, 4 months ago (April 13, 2011, 8:46 a.m.)
Deposited	6 months ago (March 4, 2025, 8:41 p.m.)
Indexed	6 months ago (March 5, 2025, 12:48 a.m.)
Issued	46 years ago (Sept. 1, 1979)
Published	46 years ago (Sept. 1, 1979)
Published Online	46 years ago (Sept. 1, 1979)
Published Print	46 years ago (Sept. 1, 1979)

Funders 0

None

BibTeX

@article{Menon_1979, title={Hypothermic effects of apomorphine homologues in mice}, volume={31}, ISSN={0022-3573}, url={http://dx.doi.org/10.1111/j.2042-7158.1979.tb13508.x}, DOI={10.1111/j.2042-7158.1979.tb13508.x}, number={1}, journal={Journal of Pharmacy and Pharmacology}, publisher={Oxford University Press (OUP)}, author={Menon, M K and Clark, W G and Cannon, J G}, year={1979}, month=sep, pages={318–321} }

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