DOI: 10.1111/j.2042-7158.1962.tb11181.x. The Bacteriostatic Actions of Tetracycline and Oxytetracycline

The Bacteriostatic Actions of Tetracycline and Oxytetracycline

10.1111/j.2042-7158.1962.tb11181.x

Crossref journal-article

Oxford University Press (OUP)

Journal of Pharmacy and Pharmacology (286)

Abstract

Abstract The bacteriostatic actions of tetracycline and oxytetracycline on cultures of A. aerogenes in glucose-mineral salt media have been studied. Both antibiotics show two modes of action, one of which is non-operative under aerobic conditions and is ascribed to an interference with the disposal of hydrogen in unaerated cultures. The other mode of action can be accounted for by an interference with the synthesis of protein. Quantitative measurements of the dependence of the degree of inhibition on the pH and the concentration of magnesium ions are in accord with attributing inhibitory power solely to the non-ionic molecular forms of the antibiotics. The possible contributions of the two modes of action to the cytotoxic action are discussed.

Bibliography

Jones, J. G., & Morrison, G. A. (1962). The Bacteriostatic Actions of Tetracycline and Oxytetracycline. Journal of Pharmacy and Pharmacology, 14(1), 808â824.

Authors 2

J G Jones (first)
G A Morrison (additional)

References 21 Referenced 24

10.1038/172201a0 / Nature, Lond. by Albert (1953)
10.1038/177433a0 / Nature, Lond. by Albert (1956)
{'key': '2024110407063265800_cit3', 'first-page': '77', 'volume-title': 'Textbook of Physiology and Biochemistry', 'author': 'Bell', 'year': '1950'} / Textbook of Physiology and Biochemistry by Bell (1950)
{'key': '2024110407063265800_cit4', 'first-page': '40', 'volume': '144', 'author': 'Boodie', 'year': '1951', 'journal-title': 'Science'} / Science by Boodie (1951)
10.1016/S0021-9258(18)56565-0 / J. biol. Chem. by Clark (1949)
10.1099/00221287-5-3-508 / J. gen. Microbiol. by Dagley (1951)
10.1126/science.133.3447.196 / Science by Du Buy (1961)
{'key': '2024110407063265800_cit8', 'first-page': '2925', 'volume-title': 'J. chem. Soc.', 'author': 'Dunsmore', 'year': '1951'} / J. chem. Soc. by Dunsmore (1951)
10.1146/annurev.mi.09.100155.001133 / Ann. Rev. Microbiol. by Eagle (1955)
10.1042/bj0510055 / Biochem. J. by Fahmy (1952)
{'volume-title': 'Antibiotics, Their Chemistry and Non-Medical Uses, (a) 43, (b) 79', 'year': '1959', 'author': 'Goldberg', 'key': '2024110407063265800_cit11'} / Antibiotics, Their Chemistry and Non-Medical Uses, (a) 43, (b) 79 by Goldberg (1959)
10.1016/S0021-9258(18)73159-1 / J. biol. Chem. by Greenwald (1940)
10.1038/1911276a0 / Nature, Lond. by Harris (1961)
10.1126/science.109.2824.144 / Science by Kun (1949)
{'key': '2024110407063265800_cit15', 'first-page': '87', 'volume': '19', 'author': 'Milch', 'year': '1957', 'journal-title': 'J. Natl., Cancer Inst.'} / J. Natl., Cancer Inst. by Milch (1957)
10.1038/1761178a0 / Nature, Lond. by Morrison (1955)
10.1021/ja01153a050 / J. Amer. chem. Soc. by Regna (1951)
{'volume-title': 'Electrolytic Solutions', 'year': '1959', 'author': 'Robinson', 'key': '2024110407063265800_cit18'} / Electrolytic Solutions by Robinson (1959)
10.1021/ja01597a081 / J. Amer. chem. Soc. by Stephens (1956)
10.1128/jb.65.3.245-251.1953 / J. Bact. by Somerson (1953)
{'key': '2024110407063265800_cit21', 'first-page': '215', 'volume': '4', 'author': 'Welch', 'year': '1957', 'journal-title': 'Antibiot. Med. and Clin. Therapy'} / Antibiot. Med. and Clin. Therapy by Welch (1957)

Dates

Type	When
Created	14 years, 4 months ago (April 12, 2011, 9:57 p.m.)
Deposited	10 months ago (Nov. 4, 2024, 2:06 a.m.)
Indexed	10 months ago (Nov. 4, 2024, 2:40 a.m.)
Issued	63 years ago (Sept. 1, 1962)
Published	63 years ago (Sept. 1, 1962)
Published Online	63 years ago (Sept. 1, 1962)
Published Print	63 years ago (Sept. 1, 1962)

Funders 0

None

BibTeX

@article{Jones_1962, title={The Bacteriostatic Actions of Tetracycline and Oxytetracycline}, volume={14}, ISSN={0022-3573}, url={http://dx.doi.org/10.1111/j.2042-7158.1962.tb11181.x}, DOI={10.1111/j.2042-7158.1962.tb11181.x}, number={1}, journal={Journal of Pharmacy and Pharmacology}, publisher={Oxford University Press (OUP)}, author={Jones, J G and Morrison, G A}, year={1962}, month=sep, pages={808–824} }

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