DOI: 10.1111/j.1751-1097.1997.tb03214.x. Human Blue‐light Photoreceptor hCRY2 Specifically Interacts with Protein Serine/Threonine Phosphatase 5 and Modulates Its Activity

Human Blue‐light Photoreceptor hCRY2 Specifically Interacts with Protein Serine/Threonine Phosphatase 5 and Modulates Its Activity

10.1111/j.1751-1097.1997.tb03214.x

Crossref journal-article

Wiley

Photochemistry and Photobiology (311)

Abstract

Abstract— Photolyase/blue‐light photoreceptor family of proteins includes cyclobutane pyrimidine dimer photolyase, (6‐4) photolyase and blue‐light photoreceptors that were recently discovered in Arabidopsis thaliana, Sinapis alba and Chlamydomonas reinhardtii. Recently, we identified two human genes, hCRYl and hCRY2, belonging to this family. The proteins encoded by these genes have no DNA repair activity and therefore were hypothesized to function in human blue‐light response reactions. To identify downstream targets for these putative blue‐light photoreceptors we searched for interacting proteins by the yeast two‐hybrid method. We found that the tetratricopeptide repeat protein 1, Tpr1, and the protein serine/ threonine phosphatase 5 (PP5) that contains the TPR motif specifically interacted with hCRY2. The effect of the hCRY2‐PP5 interaction on the protein phosphatase activity was investigated. We found that hCRY2, but not the highly homologous (6‐4) photolyase, inhibits the phosphatase activity of PP5. This inhibition may be on the pathway of blue‐light signal transduction reaction in humans.

Bibliography

Zhao, S., & Sancar, A. (1997). Human Blueâlight Photoreceptor hCRY2 Specifically Interacts with Protein Serine/Threonine Phosphatase 5 and Modulates Its Activity. Photochemistry and Photobiology, 66(5), 727â731. Portico.

Authors 2

Shaying Zhao (first)
Aziz Sancar (additional)

References 29 Referenced 65

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Dates

Type	When
Created	17 years, 8 months ago (Jan. 2, 2008, 1:45 p.m.)
Deposited	1 year, 10 months ago (Oct. 27, 2023, 4 p.m.)
Indexed	2 months ago (July 3, 2025, 8:27 a.m.)
Issued	27 years, 10 months ago (Nov. 1, 1997)
Published	27 years, 10 months ago (Nov. 1, 1997)
Published Online	17 years, 8 months ago (Jan. 2, 2008)
Published Print	27 years, 10 months ago (Nov. 1, 1997)

Funders 0

None

BibTeX

@article{Zhao_1997, title={Human Blue‐light Photoreceptor hCRY2 Specifically Interacts with Protein Serine/Threonine Phosphatase 5 and Modulates Its Activity}, volume={66}, ISSN={1751-1097}, url={http://dx.doi.org/10.1111/j.1751-1097.1997.tb03214.x}, DOI={10.1111/j.1751-1097.1997.tb03214.x}, number={5}, journal={Photochemistry and Photobiology}, publisher={Wiley}, author={Zhao, Shaying and Sancar, Aziz}, year={1997}, month=nov, pages={727–731} }

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