DOI: 10.1111/j.1751-1097.1992.tb08521.x. STUDIES ON HUMAN LENS: I. ORIGIN AND DEVELOPMENT OF FLUORESCENT PIGMENTS

STUDIES ON HUMAN LENS: I. ORIGIN AND DEVELOPMENT OF FLUORESCENT PIGMENTS

10.1111/j.1751-1097.1992.tb08521.x

Crossref journal-article

Wiley

Photochemistry and Photobiology (311)

Abstract

Abstract— Fluorescence spectra of normal mature human lenses have been measured and at least eight species with distinct emission characteristics identified. To determine the specific photochemical and photophysical processes responsible for the origin and development of these fluorophores, emission behavior of the products generated by successive irradiation of young human lenses (3–6 y old) as well as of L‐tryptophan solution have been systematically monitored. Fluorescent products that resulted from this irradiation were comparable to many of the fluorophores detected in aged lenses, indicating that light plays a major role in the development of these pigments. In addition to photogenerated species, there are other compounds in human lenses, presumably advanced glycosylated end products, with marked fluorescence properties.Several oxidation products of tryptophan including N‐formylkynurenine or its derivatives, β‐carboline or its derivatives, and anthranilic acid have been identified in the mature human lens. The development of several photoproducts also was attributed to endogenous ascorbate‐mediated Maillard reaction products, which undergo photoconversion by the visible light. Although some of these chromophores could act as photosensitaizers, the sensitizing efficiency of many are low. Conversely, the near‐UV filtering capability of these colored compounds conceivably could protect the vitreous and retina from development of any photochemical lesion.

Bibliography

Sen, A. C., Ueno, N., & Chakrabarti, B. (1992). STUDIES ON HUMAN LENS: I. ORIGIN AND DEVELOPMENT OF FLUORESCENT PIGMENTS. Photochemistry and Photobiology, 55(5), 753â764. Portico.

Authors 3

Asok C. Sen (first)
Norio Ueno (additional)
Bireswar Chakrabarti (additional)

References 60 Referenced 36

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Araki N. N.Ueno B.Chakrabarti Y.MorinoandS.Horiuchi(1992)Direct evidence for the presence of advanced glycation end products in human lens proteins and its positive correlation with aging.Nature(Submitted). (10.1016/S0021-9258(19)50004-7)
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{'key': 'e_1_2_1_11_1', 'first-page': '88', 'article-title': 'Cataracts and photochemical damages in the lens', 'volume': '106', 'author': 'Borkman R. F.', 'year': '1984', 'journal-title': 'Ciba Found. Symp.'} / Ciba Found. Symp. / Cataracts and photochemical damages in the lens by Borkman R. F. (1984)
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10.1111/j.1751-1097.1984.tb03890.x
{'key': 'e_1_2_1_15_1', 'first-page': '327', 'volume-title': 'Molecular and Cellular Biology of the Eye Lens', 'author': 'Jong W. W.', 'year': '1981'} / Molecular and Cellular Biology of the Eye Lens by Jong W. W. (1981)
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Dates

Type	When
Created	15 years, 1 month ago (July 24, 2010, 5:50 a.m.)
Deposited	2 years ago (Aug. 28, 2023, 7:16 a.m.)
Indexed	1 month ago (Aug. 2, 2025, 1:11 a.m.)
Issued	33 years, 4 months ago (May 1, 1992)
Published	33 years, 4 months ago (May 1, 1992)
Published Online	17 years, 8 months ago (Jan. 2, 2008)
Published Print	33 years, 4 months ago (May 1, 1992)

Funders 0

None

BibTeX

@article{Sen_1992, title={STUDIES ON HUMAN LENS: I. ORIGIN AND DEVELOPMENT OF FLUORESCENT PIGMENTS}, volume={55}, ISSN={1751-1097}, url={http://dx.doi.org/10.1111/j.1751-1097.1992.tb08521.x}, DOI={10.1111/j.1751-1097.1992.tb08521.x}, number={5}, journal={Photochemistry and Photobiology}, publisher={Wiley}, author={Sen, Asok C. and Ueno, Norio and Chakrabarti, Bireswar}, year={1992}, month=may, pages={753–764} }

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  "references-count": 60,
  "journal-issue": {
    "issue": "5",
    "published-print": {
      "date-parts": [
        [
          1992,
          5
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1111/j.1751-1097.1992.tb08521.x"
  ],
  "URL": "http://dx.doi.org/10.1111/j.1751-1097.1992.tb08521.x",
  "relation": {},
  "ISSN": [
    "0031-8655",
    "1751-1097"
  ],
  "subject": [],
  "container-title-short": "Photochem &amp; Photobiology",
  "published": {
    "date-parts": [
      [
        1992,
        5
      ]
    ]
  }
}