DOI: 10.1111/j.1751-1097.1989.tb09195.x. TOPICAL UROCANIC ACID ENHANCES UV‐INDUCED TUMOUR YIELD AND MALIGNANCY IN THE HAIRLESS MOUSE

TOPICAL UROCANIC ACID ENHANCES UV‐INDUCED TUMOUR YIELD AND MALIGNANCY IN THE HAIRLESS MOUSE

10.1111/j.1751-1097.1989.tb09195.x

Crossref journal-article

Wiley

Photochemistry and Photobiology (311)

Abstract

Abstract— Epidermal urocanic acid has been postulated to be the mediator of the specific state of immunosuppression induced by UV irradiation, by which UV‐initiated tumour cells are able to evade normal recognition and can survive to grow progressively into malignant tumours. These experiments demonstrate that topical application of UV‐irradiated urocanic acid systemically suppresses the contact type hypersensitivity response to oxazolone in hairless mice. In addition, topically applied urocanic acid markedly increases the overt tumour yield and the degree of malignancy in hairless mice exposed chronically to daily minimally erythema] doses of simulated solar UV light. Topical urocanic acid also increases the number of latent UV‐initiated tumours, detectable by croton oil promotion. Therefore UV photoproducts of urocanic acid can both systemically suppress contact hypersensitivitv in the epidermis, and also enhance early survival of UV‐initiated tumour cells resulting in augmentation of UV photocarcinogenesis.

Bibliography

REEVE, V. E., GREENOAK, G. E., CANFIELD, P. J., BOEHMâWILCOX, C., & GALLAGHER, C. H. (1989). TOPICAL UROCANIC ACID ENHANCES UVâINDUCED TUMOUR YIELD AND MALIGNANCY IN THE HAIRLESS MOUSE. Photochemistry and Photobiology, 49(4), 459â464. Portico.

Authors 5

VIVIENNE E. REEVE (first)
GAVIN E. GREENOAK (additional)
PAUL J. CANFIELD (additional)
CHRISTA BOEHM‐WILCOX (additional)
CLIFFORD H. GALLAGHER (additional)

References 30 Referenced 72

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{'key': 'e_1_2_1_10_1', 'first-page': '319', 'article-title': 'Further evidence that the photore ceptor mediating UV‐induced systemic immune suppression is urocanic acid (abstr)', 'volume': '80', 'author': 'Fabo E. C.', 'year': '1983', 'journal-title': 'J. Invest. Dermatol.'} / J. Invest. Dermatol. / Further evidence that the photore ceptor mediating UV‐induced systemic immune suppression is urocanic acid (abstr) by Fabo E. C. (1983)
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10.1016/0006-3002(53)90168-1

Dates

Type	When
Created	17 years, 7 months ago (Jan. 2, 2008, 4:06 p.m.)
Deposited	1 year, 10 months ago (Oct. 22, 2023, 7:49 a.m.)
Indexed	4 months, 4 weeks ago (April 3, 2025, 2:23 a.m.)
Issued	36 years, 4 months ago (April 1, 1989)
Published	36 years, 4 months ago (April 1, 1989)
Published Online	17 years, 7 months ago (Jan. 2, 2008)
Published Print	36 years, 4 months ago (April 1, 1989)

Funders 0

None

BibTeX

@article{REEVE_1989, title={TOPICAL UROCANIC ACID ENHANCES UV‐INDUCED TUMOUR YIELD AND MALIGNANCY IN THE HAIRLESS MOUSE}, volume={49}, ISSN={1751-1097}, url={http://dx.doi.org/10.1111/j.1751-1097.1989.tb09195.x}, DOI={10.1111/j.1751-1097.1989.tb09195.x}, number={4}, journal={Photochemistry and Photobiology}, publisher={Wiley}, author={REEVE, VIVIENNE E. and GREENOAK, GAVIN E. and CANFIELD, PAUL J. and BOEHM‐WILCOX, CHRISTA and GALLAGHER, CLIFFORD H.}, year={1989}, month=apr, pages={459–464} }

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