Abstract
AbstractGroups of mice were exposed to a single dose of UV radiation before or after immunization with Candida albicans. The delayed type hypersensitivity (DTH) response was markedly depressed in all UV‐irradiated groups. Exposure of mice to UV radiation before sensitization induced splenic suppressor cells that, upon transfer to normal recipients, impaired the induction of DTH to Candida. In contrast, exposure of mice to UV radiation after sensitization interfered with elicitation of the DTH response, but this suppression was not transferable. These studies demonstrate that immunity to Candida albicans in mice is impaired by exposure to UV radiation and that two separate mechanisms may be involved.
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Dates
Type | When |
---|---|
Created | 17 years, 8 months ago (Jan. 2, 2008, 4:04 p.m.) |
Deposited | 1 year, 10 months ago (Oct. 21, 2023, 8:48 p.m.) |
Indexed | 3 months ago (June 1, 2025, 10:21 a.m.) |
Issued | 36 years, 4 months ago (May 1, 1989) |
Published | 36 years, 4 months ago (May 1, 1989) |
Published Online | 17 years, 8 months ago (Jan. 2, 2008) |
Published Print | 36 years, 4 months ago (May 1, 1989) |
@article{DENKINS_1989, title={EXPOSURE OF MICE TO UV‐B RADIATION SUPPRESSES DELAYED HYPERSENSITIVITY TO Candida albicans}, volume={49}, ISSN={1751-1097}, url={http://dx.doi.org/10.1111/j.1751-1097.1989.tb08432.x}, DOI={10.1111/j.1751-1097.1989.tb08432.x}, number={5}, journal={Photochemistry and Photobiology}, publisher={Wiley}, author={DENKINS, YVONNE and FIDLER, ISAIAH J. and KRIPKE, MARGARET L.}, year={1989}, month=may, pages={615–619} }