DOI: 10.1111/j.1750-3639.2002.tb00421.x. Argyrophilic Grain Disease: Neuropathology, Frequency in a Dementia Brain Bank and Lack of Relationship with Apolipoprotein E

Argyrophilic Grain Disease: Neuropathology, Frequency in a Dementia Brain Bank and Lack of Relationship with Apolipoprotein E

10.1111/j.1750-3639.2002.tb00421.x

Crossref journal-article

Wiley

Brain Pathology (311)

Abstract

Argyrophilic grain disease (AGD) is a recently recognized disorder whose relationship to dementia as well as genetic or biochemical features remain incompletely characterized in part due to diagnostic difficulties engendered by concomitant pathologies. In the present study, we reviewed a consecutive series of over 300 brains referred for evaluation of dementia for presence of argyrophilic grains (AGs). AGs were found in the hippocampal region and amygdala, and were accompanied by coiled bodies in the underlying white matter and ballooned neurons in the limbic lobe. Ballooned neurons were also found in the limbic lobe in a number of cases of advanced Alzheimer's disease (AD) that did not have AGs, supporting the lack of diagnostic significance of ballooned neurons confined to limbic lobe. The frequency of AGD in this series of dementia brains was 4.9% and was similar to the frequency in other autopsy series of nondemented cases, supporting the notion that there is no obligatory relationship between AGD and dementia. In the present series, ApoE E4 allele frequency of AGD was dependent on concurrent AD, with AGD cases lacking AD similar to controls and cases with concurrent AD similar to AD. This suggests that AGD is an independent disease process from AD.

Bibliography

Togo, T., Cookson, N., & Dickson, D. W. (2002). Argyrophilic Grain Disease: Neuropathology, Frequency in a Dementia Brain Bank and Lack of Relationship with Apolipoprotein E. Brain Pathology, 12(1), 45â52. Portico.

Authors 3

Takashi Togo (first)
Natalie Cookson (additional)
Dennis W. Dickson (additional)

References 24 Referenced 80

10.1016/0006-8993(89)91396-6
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{'key': 'e_1_2_1_11_2', 'first-page': '1', 'article-title': "Silver staining of Alzheimer's neurofibrillary changes by means of physical development", 'volume': '19', 'author': 'Gallyas F', 'year': '1971', 'journal-title': 'Acta Morph Acad Sci Hung'} / Acta Morph Acad Sci Hung / Silver staining of Alzheimer's neurofibrillary changes by means of physical development by Gallyas F (1971)
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{'key': 'e_1_2_1_13_2', 'first-page': '1472', 'article-title': "Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Significance for etiological theories of Alzheimer's disease", 'volume': '145', 'author': 'Harrington CR', 'year': '1994', 'journal-title': 'Am J Pathol'} / Am J Pathol / Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Significance for etiological theories of Alzheimer's disease by Harrington CR (1994)
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{'key': 'e_1_2_1_15_2', 'first-page': '278', 'article-title': 'Clinical aspects of argyrophilic grain disease', 'volume': '19', 'author': 'Ikeda K', 'year': '2000', 'journal-title': 'Clin Neuropathol'} / Clin Neuropathol / Clinical aspects of argyrophilic grain disease by Ikeda K (2000)
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10.1016/S0304-3940(98)00250-X
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10.1007/s004010050642

Dates

Type	When
Created	15 years, 1 month ago (July 27, 2010, 8:09 a.m.)
Deposited	1 year, 9 months ago (Nov. 17, 2023, 5:09 p.m.)
Indexed	3 months ago (June 2, 2025, 3:47 a.m.)
Issued	23 years, 8 months ago (Jan. 1, 2002)
Published	23 years, 8 months ago (Jan. 1, 2002)
Published Online	19 years, 5 months ago (April 5, 2006)
Published Print	23 years, 8 months ago (Jan. 1, 2002)

Funders 0

None

BibTeX

@article{Togo_2002, title={Argyrophilic Grain Disease: Neuropathology, Frequency in a Dementia Brain Bank and Lack of Relationship with Apolipoprotein E}, volume={12}, ISSN={1750-3639}, url={http://dx.doi.org/10.1111/j.1750-3639.2002.tb00421.x}, DOI={10.1111/j.1750-3639.2002.tb00421.x}, number={1}, journal={Brain Pathology}, publisher={Wiley}, author={Togo, Takashi and Cookson, Natalie and Dickson, Dennis W.}, year={2002}, month=jan, pages={45–52} }

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