DOI: 10.1111/j.1750-3639.1998.tb00162.x. Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17: A New Group of Tauopathies

Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17: A New Group of Tauopathies

10.1111/j.1750-3639.1998.tb00162.x

Crossref journal-article

Wiley

Brain Pathology (311)

Abstract

Frontotemporal dementia is a neurological disorder characterised by personality changes, deterioration of memory and executive functions as well as stereotypical behaviour. Sometimes a Parkinsonian syndrome is prominent. Several cases of frontotemporal dementia are hereditary and recently families have been identified where the disease is linked to chromosome 17q21–22. Although, there is clinical and neuropathological variability among and within families, they all consistently present a symptomathology that has led investigatores to name the disease “Frontotemporal Dementia and Parkinson‐ismlinked to chromosome 17.” Neuropathologically, these patients present with atrophy of frontal and temporal cortex as well as of basal ganglia and substantia nigra. In the majority of cases these features are accompanied by neuronal loss, gliosis and microtubule‐associated protein tau deposits which can be present in both neurones and glial cells. The distribution, structural and biochemical characteristics of the tau deposits differentiate them from those present in Alzheimer's disease, corticobasal degeneration, progressive supranuclear palsy and Pick's disease. No (β‐amyloid deposits are present. The clinical and neuropathological features of the disease in these families suggest that Frontotemporal Dementia and Parkinsonism linked to chromosome 17 is a distinct disorder. The presence of abundant tau deposits in the majority of these families define this disorder as a new tauopathy.

Bibliography

Spillantini, M. G., Bird, T. D., & Ghetti, B. (1998). Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17: A New Group of Tauopathies. Brain Pathology, 8(2), 387â402. Portico.

Authors 3

Maria Grazia Spillantini (first)
Thomas D. Bird (additional)
Bernardino Ghetti (additional)

References 79 Referenced 322

10.1021/bi00158a027
10.1212/WNL.42.3.631
10.1002/ana.410420516
10.1007/BF00296494
10.1001/archneur.1997.00550170021010
10.1212/WNL.48.4.949
10.1007/BF00308809
10.1136/jnnp.56.5.473
10.1093/hmg/4.9.1625
10.1136/jnnp.57.4.416
10.1097/00005072-199605000-00001
{'key': 'e_1_2_1_12_2', 'first-page': '175', 'article-title': 'Familial aphasia: the Pick‐Alzheimer spectrum', 'volume': '104', 'author': 'Cole M', 'year': '1979', 'journal-title': 'Trans Am Neurol Ass'} / Trans Am Neurol Ass / Familial aphasia: the Pick‐Alzheimer spectrum by Cole M (1979)
10.1002/ana.410410222
{'key': 'e_1_2_1_14_2', 'first-page': '217', 'article-title': 'Magnetic resonance imaging studies in rapidly progressive autosomal dominant parkinsonism and dementia with pallido‐ponto‐nigral degeneration', 'volume': '1', 'author': 'Cordes M', 'year': '1992', 'journal-title': 'Neurodegeneration'} / Neurodegeneration / Magnetic resonance imaging studies in rapidly progressive autosomal dominant parkinsonism and dementia with pallido‐ponto‐nigral degeneration by Cordes M (1992)
10.1016/0888-7543(95)80134-8
10.1073/pnas.88.6.2288
10.3109/00048679709073812
10.1093/brain/118.5.1095
10.1002/ana.410400204
10.1007/BF00296367
10.1002/ana.410410606
10.1016/0888-7543(95)80133-7
10.1002/(SICI)1096-8628(19970725)74:4<380::AID-AJMG8>3.0.CO;2-T
10.1007/BF00309628
10.1016/0896-6273(89)90210-9
10.1002/j.1460-2075.1989.tb03390.x
10.1002/j.1460-2075.1990.tb07870.x
10.1016/0896-6273(92)90117-V
10.1038/383550a0
10.1073/pnas.87.15.5827
10.1016/S0021-9258(18)48531-6
10.1212/WNL.47.4.1106-a
10.1093/brain/105.3.443
10.1159/000107313
10.1016/S0896-6273(00)80309-8
10.1002/ana.410410205
10.1007/s004010050403
10.1006/geno.1994.1473
10.1093/brain/104.1.61
10.1212/WNL.40.2.251
{'key': 'e_1_2_1_41_2', 'first-page': '1', 'article-title': 'Ultrastructure and biochemical composition of paired helical filaments in corticobasal degeneration', 'volume': '145', 'author': 'Ksiezak‐Reding H', 'year': '1994', 'journal-title': 'Am J Pathol'} / Am J Pathol / Ultrastructure and biochemical composition of paired helical filaments in corticobasal degeneration by Ksiezak‐Reding H (1994)
10.1212/WNL.44.9.1633
10.1016/0197-4580(94)92978-5
10.1126/science.1899488
10.1212/WNL.44.10.1878
10.1136/jnnp.56.6.605
10.1006/geno.1995.1101
10.1212/WNL.41.9.1374
10.1097/00005072-199505000-00148
10.1002/ana.410160407
10.1016/0014-5793(94)00702-0
10.1086/301594
10.1016/0169-328X(86)90033-1
10.1016/S0304-3940(97)00161-4
{'key': 'e_1_2_1_55_2', 'first-page': '160', 'article-title': 'Spectrum of frontal lobe dementia in a Swedish family', 'volume': '4', 'author': 'Passant U', 'journal-title': 'Dementia'} / Dementia / Spectrum of frontal lobe dementia in a Swedish family by Passant U
10.1212/WNL.45.6.1062
10.1126/science.278.5336.245
10.1002/ana.410420406
10.1136/jnnp.31.5.479
10.1111/j.1469-1809.1959.tb01476.x
10.1097/00005072-199605000-00006
10.1002/ana.410390609
10.1007/s004010050487
10.1073/pnas.94.8.4113
{'key': 'e_1_2_1_65_2', 'first-page': '213', 'volume-title': "Alzheimer's disease: biology, diagnosis and therapeutics", 'author': 'Spillantini MG', 'year': '1997'} / Alzheimer's disease: biology, diagnosis and therapeutics by Spillantini MG (1997)
{'key': 'e_1_2_1_66_2', 'first-page': '1149', 'article-title': 'Neuropathological features of frontotemporal dementia and parkinsonism linked to chromosome 17q21–22 (FTDP‐17): Duke family 1684', 'volume': '7', 'author': 'Spillantini MG', 'year': '1997', 'journal-title': 'Brain Pathol'} / Brain Pathol / Neuropathological features of frontotemporal dementia and parkinsonism linked to chromosome 17q21–22 (FTDP‐17): Duke family 1684 by Spillantini MG (1997)
10.1212/WNL.42.1.120
10.1006/nbdi.1996.0016
10.1016/S0006-8993(97)00830-5
{'key': 'e_1_2_1_70_2', 'first-page': '257', 'article-title': 'Abundant neurofibrillary tangles without senile plaques in a subset of patients with senile dementia', 'volume': '1', 'author': 'Ulrich J', 'year': '1992', 'journal-title': 'Neurodegeneration'} / Neurodegeneration / Abundant neurofibrillary tangles without senile plaques in a subset of patients with senile dementia by Ulrich J (1992)
{'key': 'e_1_2_1_71_2', 'first-page': '439', 'article-title': 'Demonstration of a specific profile of pathological tau proteins in frontotemporal dementia cases', 'volume': '318', 'author': 'Vermersch P', 'year': '1995', 'journal-title': 'CR Acad Sci'} / CR Acad Sci / Demonstration of a specific profile of pathological tau proteins in frontotemporal dementia cases by Vermersch P (1995)
10.1093/hmg/5.1.151
10.1002/ana.410410202
{'key': 'e_1_2_1_74_2', 'first-page': '1159', 'article-title': 'Localization of disinhibition‐dementia‐parkinsonism‐amyotrophy complex to 17q21–22', 'volume': '55', 'author': 'Wilhelmsen KC', 'year': '1994', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / Localization of disinhibition‐dementia‐parkinsonism‐amyotrophy complex to 17q21–22 by Wilhelmsen KC (1994)
10.1002/ana.410320303
10.1016/S1353-8020(97)00006-0
{'key': 'e_1_2_1_77_2', 'first-page': '26', 'article-title': 'Histological and biochemical pathology in a family with autosomal dominant parkinsonism and dementia', 'volume': '2', 'author': 'Yamada T', 'year': '1993', 'journal-title': 'Neurol Psychiatr Brain Res'} / Neurol Psychiatr Brain Res / Histological and biochemical pathology in a family with autosomal dominant parkinsonism and dementia by Yamada T (1993)
{'key': 'e_1_2_1_78_2', 'first-page': '1306', 'article-title': 'Linkage of frontotemporal dementia to chromosome 17: clinical and neuropathological characterization of phenotype', 'volume': '59', 'author': 'Yamaoka LH', 'year': '1996', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / Linkage of frontotemporal dementia to chromosome 17: clinical and neuropathological characterization of phenotype by Yamaoka LH (1996)
10.1016/0092-8674(91)90389-G

Dates

Type	When
Created	15 years, 1 month ago (July 27, 2010, 12:58 a.m.)
Deposited	1 year, 10 months ago (Oct. 27, 2023, 6:25 p.m.)
Indexed	1 month, 2 weeks ago (July 16, 2025, 8:16 a.m.)
Issued	27 years, 5 months ago (April 1, 1998)
Published	27 years, 5 months ago (April 1, 1998)
Published Online	19 years, 4 months ago (April 5, 2006)
Published Print	27 years, 5 months ago (April 1, 1998)

Funders 0

None

BibTeX

@article{Spillantini_1998, title={Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17: A New Group of Tauopathies}, volume={8}, ISSN={1750-3639}, url={http://dx.doi.org/10.1111/j.1750-3639.1998.tb00162.x}, DOI={10.1111/j.1750-3639.1998.tb00162.x}, number={2}, journal={Brain Pathology}, publisher={Wiley}, author={Spillantini, Maria Grazia and Bird, Thomas D. and Ghetti, Bernardino}, year={1998}, month=apr, pages={387–402} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        16
      ]
    ],
    "date-time": "2025-07-16T12:16:50Z",
    "timestamp": 1752668210682
  },
  "reference-count": 79,
  "publisher": "Wiley",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2006,
            4,
            5
          ]
        ],
        "date-time": "2006-04-05T00:00:00Z",
        "timestamp": 1144195200000
      },
      "content-version": "vor",
      "delay-in-days": 2926,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1998,
        4
      ]
    ]
  },
  "abstract": "<jats:p>Frontotemporal dementia is a neurological disorder characterised by personality changes, deterioration of memory and executive functions as well as stereotypical behaviour. Sometimes a Parkinsonian syndrome is prominent. Several cases of frontotemporal dementia are hereditary and recently families have been identified where the disease is linked to chromosome 17q21\u201322. Although, there is clinical and neuropathological variability among and within families, they all consistently present a symptomathology that has led investigatores to name the disease \u201cFrontotemporal Dementia and Parkinson\u2010ismlinked to chromosome 17.\u201d Neuropathologically, these patients present with atrophy of frontal and temporal cortex as well as of basal ganglia and substantia nigra. In the majority of cases these features are accompanied by neuronal loss, gliosis and microtubule\u2010associated protein tau deposits which can be present in both neurones and glial cells. The distribution, structural and biochemical characteristics of the tau deposits differentiate them from those present in Alzheimer's disease, corticobasal degeneration, progressive supranuclear palsy and Pick's disease. No (\u03b2\u2010amyloid deposits are present. The clinical and neuropathological features of the disease in these families suggest that Frontotemporal Dementia and Parkinsonism linked to chromosome 17 is a distinct disorder. The presence of abundant tau deposits in the majority of these families define this disorder as a new tauopathy.</jats:p>",
  "DOI": "10.1111/j.1750-3639.1998.tb00162.x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2010,
        7,
        27
      ]
    ],
    "date-time": "2010-07-27T04:58:34Z",
    "timestamp": 1280206714000
  },
  "page": "387-402",
  "source": "Crossref",
  "is-referenced-by-count": 322,
  "title": "Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17: A New Group of Tauopathies",
  "prefix": "10.1111",
  "volume": "8",
  "author": [
    {
      "given": "Maria Grazia",
      "family": "Spillantini",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Thomas D.",
      "family": "Bird",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Bernardino",
      "family": "Ghetti",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2006,
        4,
        5
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_1_1_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi00158a027"
    },
    {
      "key": "e_1_2_1_2_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1212/WNL.42.3.631"
    },
    {
      "key": "e_1_2_1_3_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/ana.410420516"
    },
    {
      "key": "e_1_2_1_4_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00296494"
    },
    {
      "key": "e_1_2_1_5_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1001/archneur.1997.00550170021010"
    },
    {
      "key": "e_1_2_1_6_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1212/WNL.48.4.949"
    },
    {
      "key": "e_1_2_1_7_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00308809"
    },
    {
      "key": "e_1_2_1_8_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/jnnp.56.5.473"
    },
    {
      "key": "e_1_2_1_9_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/4.9.1625"
    },
    {
      "key": "e_1_2_1_10_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/jnnp.57.4.416"
    },
    {
      "key": "e_1_2_1_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/00005072-199605000-00001"
    },
    {
      "key": "e_1_2_1_12_2",
      "first-page": "175",
      "article-title": "Familial aphasia: the Pick\u2010Alzheimer spectrum",
      "volume": "104",
      "author": "Cole M",
      "year": "1979",
      "journal-title": "Trans Am Neurol Ass"
    },
    {
      "key": "e_1_2_1_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/ana.410410222"
    },
    {
      "key": "e_1_2_1_14_2",
      "first-page": "217",
      "article-title": "Magnetic resonance imaging studies in rapidly progressive autosomal dominant parkinsonism and dementia with pallido\u2010ponto\u2010nigral degeneration",
      "volume": "1",
      "author": "Cordes M",
      "year": "1992",
      "journal-title": "Neurodegeneration"
    },
    {
      "key": "e_1_2_1_15_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0888-7543(95)80134-8"
    },
    {
      "key": "e_1_2_1_16_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.88.6.2288"
    },
    {
      "key": "e_1_2_1_17_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.3109/00048679709073812"
    },
    {
      "key": "e_1_2_1_18_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/brain/118.5.1095"
    },
    {
      "key": "e_1_2_1_19_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/ana.410400204"
    },
    {
      "key": "e_1_2_1_20_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00296367"
    },
    {
      "key": "e_1_2_1_21_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/ana.410410606"
    },
    {
      "key": "e_1_2_1_22_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0888-7543(95)80133-7"
    },
    {
      "key": "e_1_2_1_23_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1096-8628(19970725)74:4<380::AID-AJMG8>3.0.CO;2-T"
    },
    {
      "key": "e_1_2_1_24_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00309628"
    },
    {
      "key": "e_1_2_1_25_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0896-6273(89)90210-9"
    },
    {
      "key": "e_1_2_1_26_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1989.tb03390.x"
    },
    {
      "key": "e_1_2_1_27_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1990.tb07870.x"
    },
    {
      "key": "e_1_2_1_28_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0896-6273(92)90117-V"
    },
    {
      "key": "e_1_2_1_29_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/383550a0"
    },
    {
      "key": "e_1_2_1_30_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.87.15.5827"
    },
    {
      "key": "e_1_2_1_31_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(18)48531-6"
    },
    {
      "key": "e_1_2_1_32_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1212/WNL.47.4.1106-a"
    },
    {
      "key": "e_1_2_1_33_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/brain/105.3.443"
    },
    {
      "key": "e_1_2_1_34_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1159/000107313"
    },
    {
      "key": "e_1_2_1_35_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0896-6273(00)80309-8"
    },
    {
      "key": "e_1_2_1_36_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/ana.410410205"
    },
    {
      "key": "e_1_2_1_37_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/s004010050403"
    },
    {
      "key": "e_1_2_1_38_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/geno.1994.1473"
    },
    {
      "key": "e_1_2_1_39_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/brain/104.1.61"
    },
    {
      "key": "e_1_2_1_40_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1212/WNL.40.2.251"
    },
    {
      "key": "e_1_2_1_41_2",
      "first-page": "1",
      "article-title": "Ultrastructure and biochemical composition of paired helical filaments in corticobasal degeneration",
      "volume": "145",
      "author": "Ksiezak\u2010Reding H",
      "year": "1994",
      "journal-title": "Am J Pathol"
    },
    {
      "key": "e_1_2_1_42_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1212/WNL.44.9.1633"
    },
    {
      "key": "e_1_2_1_43_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0197-4580(94)92978-5"
    },
    {
      "key": "e_1_2_1_44_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1899488"
    },
    {
      "key": "e_1_2_1_45_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1212/WNL.44.10.1878"
    },
    {
      "key": "e_1_2_1_46_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/jnnp.56.6.605"
    },
    {
      "key": "e_1_2_1_47_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/geno.1995.1101"
    },
    {
      "key": "e_1_2_1_48_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1212/WNL.41.9.1374"
    },
    {
      "key": "e_1_2_1_49_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/00005072-199505000-00148"
    },
    {
      "key": "e_1_2_1_50_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/ana.410160407"
    },
    {
      "key": "e_1_2_1_51_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-5793(94)00702-0"
    },
    {
      "key": "e_1_2_1_52_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1086/301594"
    },
    {
      "key": "e_1_2_1_53_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0169-328X(86)90033-1"
    },
    {
      "key": "e_1_2_1_54_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0304-3940(97)00161-4"
    },
    {
      "key": "e_1_2_1_55_2",
      "first-page": "160",
      "article-title": "Spectrum of frontal lobe dementia in a Swedish family",
      "volume": "4",
      "author": "Passant U",
      "journal-title": "Dementia"
    },
    {
      "key": "e_1_2_1_56_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1212/WNL.45.6.1062"
    },
    {
      "key": "e_1_2_1_57_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.278.5336.245"
    },
    {
      "key": "e_1_2_1_58_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/ana.410420406"
    },
    {
      "key": "e_1_2_1_59_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/jnnp.31.5.479"
    },
    {
      "key": "e_1_2_1_60_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1469-1809.1959.tb01476.x"
    },
    {
      "key": "e_1_2_1_61_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/00005072-199605000-00006"
    },
    {
      "key": "e_1_2_1_62_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/ana.410390609"
    },
    {
      "key": "e_1_2_1_63_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/s004010050487"
    },
    {
      "key": "e_1_2_1_64_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.94.8.4113"
    },
    {
      "key": "e_1_2_1_65_2",
      "first-page": "213",
      "volume-title": "Alzheimer's disease: biology, diagnosis and therapeutics",
      "author": "Spillantini MG",
      "year": "1997"
    },
    {
      "key": "e_1_2_1_66_2",
      "first-page": "1149",
      "article-title": "Neuropathological features of frontotemporal dementia and parkinsonism linked to chromosome 17q21\u201322 (FTDP\u201017): Duke family 1684",
      "volume": "7",
      "author": "Spillantini MG",
      "year": "1997",
      "journal-title": "Brain Pathol"
    },
    {
      "key": "e_1_2_1_67_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1212/WNL.42.1.120"
    },
    {
      "key": "e_1_2_1_68_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/nbdi.1996.0016"
    },
    {
      "key": "e_1_2_1_69_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0006-8993(97)00830-5"
    },
    {
      "key": "e_1_2_1_70_2",
      "first-page": "257",
      "article-title": "Abundant neurofibrillary tangles without senile plaques in a subset of patients with senile dementia",
      "volume": "1",
      "author": "Ulrich J",
      "year": "1992",
      "journal-title": "Neurodegeneration"
    },
    {
      "key": "e_1_2_1_71_2",
      "first-page": "439",
      "article-title": "Demonstration of a specific profile of pathological tau proteins in frontotemporal dementia cases",
      "volume": "318",
      "author": "Vermersch P",
      "year": "1995",
      "journal-title": "CR Acad Sci"
    },
    {
      "key": "e_1_2_1_72_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/5.1.151"
    },
    {
      "key": "e_1_2_1_73_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/ana.410410202"
    },
    {
      "key": "e_1_2_1_74_2",
      "first-page": "1159",
      "article-title": "Localization of disinhibition\u2010dementia\u2010parkinsonism\u2010amyotrophy complex to 17q21\u201322",
      "volume": "55",
      "author": "Wilhelmsen KC",
      "year": "1994",
      "journal-title": "Am J Hum Genet"
    },
    {
      "key": "e_1_2_1_75_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/ana.410320303"
    },
    {
      "key": "e_1_2_1_76_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1353-8020(97)00006-0"
    },
    {
      "key": "e_1_2_1_77_2",
      "first-page": "26",
      "article-title": "Histological and biochemical pathology in a family with autosomal dominant parkinsonism and dementia",
      "volume": "2",
      "author": "Yamada T",
      "year": "1993",
      "journal-title": "Neurol Psychiatr Brain Res"
    },
    {
      "key": "e_1_2_1_78_2",
      "first-page": "1306",
      "article-title": "Linkage of frontotemporal dementia to chromosome 17: clinical and neuropathological characterization of phenotype",
      "volume": "59",
      "author": "Yamaoka LH",
      "year": "1996",
      "journal-title": "Am J Hum Genet"
    },
    {
      "key": "e_1_2_1_79_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(91)90389-G"
    }
  ],
  "container-title": "Brain Pathology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1750-3639.1998.tb00162.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1750-3639.1998.tb00162.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        10,
        27
      ]
    ],
    "date-time": "2023-10-27T22:25:28Z",
    "timestamp": 1698445528000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1111/j.1750-3639.1998.tb00162.x"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1998,
        4
      ]
    ]
  },
  "references-count": 79,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          1998,
          4
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1111/j.1750-3639.1998.tb00162.x"
  ],
  "URL": "http://dx.doi.org/10.1111/j.1750-3639.1998.tb00162.x",
  "relation": {},
  "ISSN": [
    "1015-6305",
    "1750-3639"
  ],
  "subject": [],
  "container-title-short": "Brain Pathology",
  "published": {
    "date-parts": [
      [
        1998,
        4
      ]
    ]
  }
}