DOI: 10.1111/j.1749-6632.2010.05628.x. Neuroprotective mechanisms of brain‐derived neurotrophic factor against 3‐nitropropionic acid toxicity: therapeutic implications for Huntington's disease

Neuroprotective mechanisms of brain‐derived neurotrophic factor against 3‐nitropropionic acid toxicity: therapeutic implications for Huntington's disease

10.1111/j.1749-6632.2010.05628.x

Crossref journal-article

Wiley

Annals of the New York Academy of Sciences (311)

Abstract

3‐Nitropropionic acid (3‐NP) is an irreversible inhibitor of mitochondrial succinate dehydrogenase that has been used to explore the molecular mechanisms of cell death associated with mitochondrial dysfunction and neurodegeneration for Huntington's disease (HD). Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that may regulate neuronal survival and differentiation. Experimental evidence derived from both clinical as well as basic research suggests a close association between BDNF deficiency and HD pathogenesis. In this review, we focus on recent progress in the molecular mechanisms responsible for the BDNF‐mediated neuroprotective effects against mitochondrial dysfunction induced by 3‐NP. Delineation of BDNF‐mediated neuroprotective actions against 3‐NP toxicity may add in the development of therapeutic intervention for HD where mitochondrial dysfunction is known to play a crucial role in pathogenesis of this devastating disease.

Bibliography

Wu, C., Hwang, C., Chen, S., Yin, J., & Yang, D. (2010). Neuroprotective mechanisms of brainâderived neurotrophic factor against 3ânitropropionic acid toxicity: therapeutic implications for Huntingtonâs disease. Annals of the New York Academy of Sciences, 1201(1), 8â12. Portico.

Authors 5

Chia‐Lin Wu (first)
Chi‐Shin Hwang (additional)
Shang‐Der Chen (additional)
Jiu‐Haw Yin (additional)
Ding‐I Yang (additional)

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Dates

Type	When
Created	15 years, 1 month ago (July 21, 2010, 2:02 p.m.)
Deposited	1 year, 5 months ago (March 28, 2024, 12:07 p.m.)
Indexed	2 months, 4 weeks ago (June 3, 2025, 11:15 a.m.)
Issued	15 years, 2 months ago (July 1, 2010)
Published	15 years, 2 months ago (July 1, 2010)
Published Online	15 years, 1 month ago (July 21, 2010)
Published Print	15 years, 2 months ago (July 1, 2010)

Funders 0

None

BibTeX

@article{Wu_2010, title={Neuroprotective mechanisms of brain‐derived neurotrophic factor against 3‐nitropropionic acid toxicity: therapeutic implications for Huntington’s disease}, volume={1201}, ISSN={1749-6632}, url={http://dx.doi.org/10.1111/j.1749-6632.2010.05628.x}, DOI={10.1111/j.1749-6632.2010.05628.x}, number={1}, journal={Annals of the New York Academy of Sciences}, publisher={Wiley}, author={Wu, Chia‐Lin and Hwang, Chi‐Shin and Chen, Shang‐Der and Yin, Jiu‐Haw and Yang, Ding‐I}, year={2010}, month=jul, pages={8–12} }

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