DOI: 10.1111/j.1749-6632.2000.tb06633.x. Mitochondrial Oxidative Stress and Aging in the Filamentous Fungus <i>Podospora anserina</i>

Mitochondrial Oxidative Stress and Aging in the Filamentous Fungus Podospora anserina

10.1111/j.1749-6632.2000.tb06633.x

Crossref journal-article

Wiley

Annals of the New York Academy of Sciences (311)

Abstract

Abstract: In the filamentous fungus Podospora anserina, mitochondrial oxidative stress is a major contributor to aging. Reactive oxygen species (ROS) generated as a result of electron leakage during respiration lead to damage of components of the electron transport chain. In aging wild‐type cultures, damaged proteins cannot be replaced because the mitochondrial genes encoding some of the corresponding subunits gradually become deleted from the mitochondrial DNA (mtDNA). Consequently, these defects result in an increased generation of reactive oxygen species and respiration deficits leading to cell death. Analyses of wild‐type strains and of different long‐lived mutants of P. anserina provide strong evidence that molecular mechanisms controlling aging processes in this fungus are complex and act at different levels. A basic mechanism (e.g., damage by ROS) appears to be overlaid by prominent instabilities of the mtDNA.

Bibliography

OSIEWACZ, H. D., & BORGHOUTS, C. (2000). Mitochondrial Oxidative Stress and Aging in the Filamentous Fungus Podospora anserina. Annals of the New York Academy of Sciences, 908(1), 31â39. Portico.

Authors 2

HEINZ D. OSIEWACZ (first)
CORINA BORGHOUTS (additional)

References 35 Referenced 21

{'key': 'e_1_2_7_2_2', 'first-page': '838', 'article-title': "Sur l'impossibilité d'obtenier la multiplication végétative ininterrompue et illimitée de l'ascomycète Podospora anserina", 'volume': '237', 'author': 'Rizet G.', 'year': '1953', 'journal-title': 'C.R. Hebd. Seances Acad. Sci.'} / C.R. Hebd. Seances Acad. Sci. / Sur l'impossibilité d'obtenier la multiplication végétative ininterrompue et illimitée de l'ascomycète Podospora anserina by Rizet G. (1953)
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Dates

Type	When
Created	15 years, 1 month ago (July 20, 2010, 3:15 p.m.)
Deposited	1 year, 11 months ago (Sept. 25, 2023, 3:50 p.m.)
Indexed	2 months ago (July 1, 2025, 12:34 p.m.)
Issued	25 years, 3 months ago (June 1, 2000)
Published	25 years, 3 months ago (June 1, 2000)
Published Online	19 years, 7 months ago (Jan. 25, 2006)
Published Print	25 years, 3 months ago (June 1, 2000)

Funders 0

None

BibTeX

@article{OSIEWACZ_2000, title={Mitochondrial Oxidative Stress and Aging in the Filamentous Fungus Podospora anserina}, volume={908}, ISSN={1749-6632}, url={http://dx.doi.org/10.1111/j.1749-6632.2000.tb06633.x}, DOI={10.1111/j.1749-6632.2000.tb06633.x}, number={1}, journal={Annals of the New York Academy of Sciences}, publisher={Wiley}, author={OSIEWACZ, HEINZ D. and BORGHOUTS, CORINA}, year={2000}, month=jun, pages={31–39} }

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