Regional cerebral oxidative and total glucose consumption during rest and activation studied with positron emission tomography
10.1111/j.1748-1716.1994.tb09718.x
Crossref journal-article
Wiley
Acta Physiologica Scandinavica (311)
Abstract

The relationship between regional oxidative and total rCMR in five healthy volunteers in activated and non‐activated areas of the brain has been investigated with positron emission tomography (PET). The tracers [l‐uC]‐D‐glucose and [2‐18F]2‐fluoro‐2‐deoxy‐D‐glucose were used. A previous study has shown that the former may be used to measure the rate of glucose oxidation while the latter tracer is used to measure the total rate of glucose consumption. Regional activation was performed (voluntary finger movements). Use of a computerized brain atlas enabled comparison between the regional oxidative and total rCMRglc in each volume element of the brain for the group of subjects.The values of total and oxidative rCMRgle, when calculated for each volume element of the brain and displayed in a scatter plot, were found to be symmetrically grouped around a straight line which passes close to the origin. The slope of this line varied between the subjects. This indicates that, on the average, the fraction of non‐oxidative glucose utilization is constant within each subject, regardless of the value of rCMRgle and, further, that the fraction of non‐oxidative glucose utilization varies between subjects.The total and oxidative CMRglc in the activated left hand area were 23.4 + 0.9% (mean + SEM) and 11.7 + 0.3%, respectively, higher than in the contralateral homologous non‐activated area. Our interpretation of the difference is that regional activation increases the fraction of non‐oxidative glucose consumption. This interpretation is supported by a previous PET study using [150]Oa, and by studies using MRS technique.

Bibliography

BLOMQVIST, G., SEITZ, R. J., SJÖGREN, I., HALLDIN, C., STONE‐ELANDER, S., WIDEN, L., SOLIN, O., & HAAPARANTA, M. (1994). Regional cerebral oxidative and total glucose consumption during rest and activation studied with positron emission tomography. Acta Physiologica Scandinavica, 151(1), 29–43. Portico.

Authors 8
  1. G. BLOMQVIST (first)
  2. R. J. SEITZ (additional)
  3. I. SJÖGREN (additional)
  4. C. HALLDIN (additional)
  5. S. STONE‐ELANDER (additional)
  6. L. WIDEN (additional)
  7. O. SOLIN (additional)
  8. M. HAAPARANTA (additional)
References 48 Referenced 37
  1. 10.1038/jcbfm.1989.111
  2. {'key': 'e_1_2_1_3_1', 'first-page': '85', 'article-title': "Evaluation of a newly discovered water suppression pulse sequence for high fields in vivo 'H surface coil NMR spectroscopy", 'volume': '1', 'author': 'Alger J.', 'year': '1989', 'journal-title': 'Magn Reson Med'} / Magn Reson Med / Evaluation of a newly discovered water suppression pulse sequence for high fields in vivo 'H surface coil NMR spectroscopy by Alger J. (1989)
  3. {'issue': '1', 'key': 'e_1_2_1_4_1', 'first-page': 'S386', 'article-title': 'Energy compartmentalization in neural tissue', 'volume': '9', 'author': 'Andersen B.J.', 'year': '1989', 'journal-title': 'Jf Cereb Blood Flow Metab'} / Jf Cereb Blood Flow Metab / Energy compartmentalization in neural tissue by Andersen B.J. (1989)
  4. 10.1038/jcbfm.1984.22
  5. {'issue': '1', 'key': 'e_1_2_1_6_1', 'first-page': 'S233', 'article-title': "Effects of kainate‐induced seizures on cerebral metabolism: a combined 'H and 31P study in unanesthetized rats", 'volume': '9', 'author': 'Barrère B.', 'year': '1989', 'journal-title': 'J Cereb Blood Flow Metab'} / J Cereb Blood Flow Metab / Effects of kainate‐induced seizures on cerebral metabolism: a combined 'H and 31P study in unanesthetized rats by Barrère B. (1989)
  6. {'key': 'e_1_2_1_7_1', 'volume-title': 'Parameter Estimation in Engineering and Science', 'author': 'Beck J.V.', 'year': '1977'} / Parameter Estimation in Engineering and Science by Beck J.V. (1977)
  7. 10.1097/00004728-198102000-00027
  8. 10.1097/00004728-198204000-00022
  9. 10.1038/jcbfm.1984.89
  10. {'key': 'e_1_2_1_11_1', 'first-page': '182', 'volume-title': 'Positron Emission Tomography in Clinical Research and Clinical Diagnosis. Tracer Modelling and Receptors', 'author': 'Blomqvist G.', 'year': '1989'} / Positron Emission Tomography in Clinical Research and Clinical Diagnosis. Tracer Modelling and Receptors by Blomqvist G. (1989)
  11. 10.1038/jcbfm.1990.89
  12. 10.1038/jcbfm.1992.38
  13. 10.1111/j.1471-4159.1987.tb01028.x
  14. 10.1111/j.1471-4159.1981.tb00607.x
  15. {'issue': '1', 'key': 'e_1_2_1_16_1', 'first-page': 'S357', 'article-title': 'Coupling of metabolic rate/blood flow in kainic‐acid‐induced seizures', 'volume': '5', 'author': 'Cremer J.E.', 'year': '1985', 'journal-title': 'J Cereb Blood Flow Metab'} / J Cereb Blood Flow Metab / Coupling of metabolic rate/blood flow in kainic‐acid‐induced seizures by Cremer J.E. (1985)
  16. 10.1038/jcbfm.1987.62
  17. 10.1109/TNS.1982.4335903
  18. {'key': 'e_1_2_1_19_1', 'first-page': '133', 'article-title': 'An automated blood sampling system used in positron emission tomography', 'volume': '3', 'author': 'Eriksson L.', 'year': '1988', 'journal-title': 'Nucl Sci Appl'} / Nucl Sci Appl / An automated blood sampling system used in positron emission tomography by Eriksson L. (1988)
  19. 10.1126/science.3260686
  20. 10.1002/jmri.1880020505
  21. 10.1097/00004728-199101000-00003
  22. {'issue': '21', 'key': 'e_1_2_1_23_1', 'first-page': '823', 'article-title': 'A remotely controlled system for the routine synthesis of 18F‐2‐fluoro‐deoxy‐D‐glucose', 'author': 'Haaparanta M.', 'year': '1984', 'journal-title': 'Nuklearmedizin'} / Nuklearmedizin / A remotely controlled system for the routine synthesis of 18F‐2‐fluoro‐deoxy‐D‐glucose by Haaparanta M. (1984)
  23. 10.1152/ajpcell.1985.248.1.C170 / Am J Physiol / Cerebral glucose use measured with [14C]glucose labeled in the 1, 2, or 6 position by Hawkins R.A. (1985)
  24. 10.1038/jcbfm.1988.17
  25. 10.1038/jcbfm.1989.128
  26. 10.1038/jcbfm.1991.106
  27. 10.1152/ajpcell.1983.245.5.C428
  28. {'key': 'e_1_2_1_29_1', 'first-page': '433', 'volume-title': 'Biochemistry', 'author': 'Mathews C.K.', 'year': '1990'} / Biochemistry by Mathews C.K. (1990)
  29. {'key': 'e_1_2_1_30_1', 'first-page': '493', 'volume-title': 'Positron Emission Tomography and Autoradiography', 'author': 'Mazziotta J.C.', 'year': '1986'} / Positron Emission Tomography and Autoradiography by Mazziotta J.C. (1986)
  30. 10.1038/jcbfm.1983.1
  31. {'key': 'e_1_2_1_32_1', 'first-page': '328', 'article-title': 'Validation of tomographic measurement of cerebral blood volume with C‐11‐labeled car‐boxyhemoglobin', 'volume': '20', 'author': 'Phelps M.E.', 'year': '1979', 'journal-title': 'J Nucl Med'} / J Nucl Med / Validation of tomographic measurement of cerebral blood volume with C‐11‐labeled car‐boxyhemoglobin by Phelps M.E. (1979)
  32. {'key': 'e_1_2_1_33_1', 'first-page': '197', 'volume-title': 'Brain Work, Alfred Benzon Symposium VIII', 'author': 'Plum F.', 'year': '1975'} / Brain Work, Alfred Benzon Symposium VIII by Plum F. (1975)
  33. 10.1111/j.1749-6632.1987.tb32894.x
  34. {'key': 'e_1_2_1_35_1', 'first-page': '48', 'article-title': 'Photic stimulation causes enhanced glycolysis in the superior collicus', 'volume': '14', 'author': 'Pulsinelli W.', 'year': '1988', 'journal-title': 'Soc Neurosci Abstr'} / Soc Neurosci Abstr / Photic stimulation causes enhanced glycolysis in the superior collicus by Pulsinelli W. (1988)
  35. 10.1038/jcbfm.1985.24
  36. 10.1152/ajplegacy.1948.154.1.73 / Am J Physiol / Brain metabolism in emotional excitement and in sleep by Richter D. (1948)
  37. 10.1038/jcbfm.1990.87
  38. 10.1111/j.1460-9568.1991.tb00835.x
  39. 10.1111/j.1600-0404.1992.tb08055.x
  40. {'key': 'e_1_2_1_41_1', 'volume-title': 'Brain Energy Metabolism, chapter 4', 'author': 'Siesjö B.K.', 'year': '1978'} / Brain Energy Metabolism, chapter 4 by Siesjö B.K. (1978)
  41. 10.1002/jlcr.2580220210
  42. 10.1007/BF00251976
  43. 10.1016/0883-2889(92)90233-5
  44. 10.1038/jcbfm.1988.89
  45. {'key': 'e_1_2_1_46_1', 'first-page': '619', 'volume-title': 'Glutamine, Glutamate and GABA in the Central Nervous System', 'author': 'Berg C.J.', 'year': '1983'} / Glutamine, Glutamate and GABA in the Central Nervous System by Berg C.J. (1983)
  46. {'key': 'e_1_2_1_47_1', 'first-page': 'S840', 'article-title': 'Influence of functional activation on the concentration of oxygenated and deoxygenated hemoglobin in human adults', 'volume': '13', 'author': 'Villringer A.', 'year': '1993', 'journal-title': 'J Cereb Blood Flow Metab'} / J Cereb Blood Flow Metab / Influence of functional activation on the concentration of oxygenated and deoxygenated hemoglobin in human adults by Villringer A. (1993)
  47. {'key': 'e_1_2_1_48_1', 'first-page': '127', 'volume-title': 'Brain Work and Mental Activity. Alfred Benzon Symposium 31', 'author': 'Widén L.', 'year': '1991'} / Brain Work and Mental Activity. Alfred Benzon Symposium 31 by Widén L. (1991)
  48. 10.1038/jcbfm.1991.92
Dates
Type When
Created 16 years, 8 months ago (Dec. 8, 2008, 5:26 p.m.)
Deposited 1 year, 10 months ago (Oct. 24, 2023, 2:48 a.m.)
Indexed 1 month, 3 weeks ago (July 7, 2025, 12:23 a.m.)
Issued 31 years, 3 months ago (May 1, 1994)
Published 31 years, 3 months ago (May 1, 1994)
Published Online 16 years, 8 months ago (Dec. 8, 2008)
Published Print 31 years, 3 months ago (May 1, 1994)
Funders 0

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@article{BLOMQVIST_1994, title={Regional cerebral oxidative and total glucose consumption during rest and activation studied with positron emission tomography}, volume={151}, ISSN={1365-201X}, url={http://dx.doi.org/10.1111/j.1748-1716.1994.tb09718.x}, DOI={10.1111/j.1748-1716.1994.tb09718.x}, number={1}, journal={Acta Physiologica Scandinavica}, publisher={Wiley}, author={BLOMQVIST, G. and SEITZ, R. J. and SJÖGREN, I. and HALLDIN, C. and STONE‐ELANDER, S. and WIDEN, L. and SOLIN, O. and HAAPARANTA, M.}, year={1994}, month=may, pages={29–43} }