DOI: 10.1111/j.1748-1716.1990.tb09029.x. Effects of growth hormone on muscle regeneration and IGF‐I concentration in old rats

Effects of growth hormone on muscle regeneration and IGF‐I concentration in old rats

10.1111/j.1748-1716.1990.tb09029.x

Crossref journal-article

Wiley

Acta Physiologica Scandinavica (311)

Abstract

A study was made of regeneration of skeletal muscle in young adult and old rats and of the effects of administration of growth hormone to old rats. Regeneration was achieved by subjecting the right extensor digitorum longus muscle to ischaemic necrosis. The level of insulin‐like growth factor I in serum was markedly decreased in old rats of 27 months of age compared with young adult rats aged 6 months. Daily injections of 4 IE recombinant human growth hormone during the 10 weeks of regeneration increased the level of insulin like growth factor I to almost the same levels as in rats aged 6 months. The body weight increased by 13% in the old rats treated with recombinant human growth hormone, while the weight of the untreated old rats was constant. The regenerating right and the normal left extensor digitorum longus muscles were studied 10 weeks after the ischaemic necrosis. The absolute and relative weights of regenerating muscle were decreased in 27‐month‐old rats compared with the rats aged 6 months. No significant difference between normal old rats and old rats treated with recombinant human growth hormone was observed either in muscle weight or in maximum contraction force. The results show that old rats have reduced levels of circulating insulin‐like growth factor I. Administration of recombinant human growth hormone raises the level of insulin‐like growth factor I to that of young adult rats, and causes an increased body weight. Muscle regeneration after ischaemic necrosis is impaired in old rats apparently by the formation of large amounts of connective tissue. Supplementation with growth hormone does not reverse this impairment.

Bibliography

ULLMAN, M., ULLMAN, A., SOMMERLAND, H., SKOTTNER, A., & OLDFORS, A. (1990). Effects of growth hormone on muscle regeneration and IGFâI concentration in old rats. Acta Physiologica Scandinavica, 140(4), 521â525. Portico.

Authors 5

M. ULLMAN (first)
A. ULLMAN (additional)
H. SOMMERLAND (additional)
A. SKOTTNER (additional)
A. OLDFORS (additional)

References 14 Referenced 29

{'key': 'e_1_2_1_2_1', 'first-page': '493', 'article-title': 'Righiration musculaires par autogreffe de cellules satellites multiplites in vitro', 'volume': '304', 'author': 'Alameddine H.', 'year': '1987', 'journal-title': 'CR Acad Sci Paris'} / CR Acad Sci Paris / Righiration musculaires par autogreffe de cellules satellites multiplites in vitro by Alameddine H. (1987)
10.1080/00313027109073739
10.1002/ar.1091830106
{'key': 'e_1_2_1_5_1', 'first-page': '113', 'volume-title': 'Clinics in Endocrinology and Metabolism', 'author': 'Clemmons D.R.', 'year': '1984'} / Clinics in Endocrinology and Metabolism by Clemmons D.R. (1984)
10.1210/jcem-51-4-781
10.1093/geronj/40.1.2
10.1016/0024-3205(76)90280-0
10.1016/S0021-9258(19)52451-6 / J Biol Chem / Protein measurement with the folin phenol reagent by Lowry O.H. (1951)
{'key': 'e_1_2_1_10_1', 'first-page': '264', 'article-title': 'Muscle regeneration. The effect of hypophysectomy on cell proliferation and expression of insulin‐like growth factor I', 'volume': '78', 'author': 'Sommeland H.', 'year': '1989', 'journal-title': 'Acta Neuropathol'} / Acta Neuropathol / Muscle regeneration. The effect of hypophysectomy on cell proliferation and expression of insulin‐like growth factor I by Sommeland H. (1989)
10.1093/geronj/40.6.689
10.1007/BF00584236
10.1111/j.1748-1716.1989.tb08612.x
10.1111/j.1748-1716.1989.tb08613.x
10.1002/mus.880050213

Dates

Type	When
Created	16 years, 8 months ago (Dec. 9, 2008, 1:29 p.m.)
Deposited	1 year, 10 months ago (Oct. 22, 2023, 6:01 a.m.)
Indexed	1 month, 3 weeks ago (July 8, 2025, 7:30 a.m.)
Issued	34 years, 9 months ago (Dec. 1, 1990)
Published	34 years, 9 months ago (Dec. 1, 1990)
Published Online	16 years, 8 months ago (Dec. 8, 2008)
Published Print	34 years, 9 months ago (Dec. 1, 1990)

Funders 0

None

BibTeX

@article{ULLMAN_1990, title={Effects of growth hormone on muscle regeneration and IGF‐I concentration in old rats}, volume={140}, ISSN={1365-201X}, url={http://dx.doi.org/10.1111/j.1748-1716.1990.tb09029.x}, DOI={10.1111/j.1748-1716.1990.tb09029.x}, number={4}, journal={Acta Physiologica Scandinavica}, publisher={Wiley}, author={ULLMAN, M. and ULLMAN, A. and SOMMERLAND, H. and SKOTTNER, A. and OLDFORS, A.}, year={1990}, month=dec, pages={521–525} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        8
      ]
    ],
    "date-time": "2025-07-08T11:30:50Z",
    "timestamp": 1751974250240
  },
  "reference-count": 14,
  "publisher": "Wiley",
  "issue": "4",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2008,
            12,
            8
          ]
        ],
        "date-time": "2008-12-08T00:00:00Z",
        "timestamp": 1228694400000
      },
      "content-version": "vor",
      "delay-in-days": 6582,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1990,
        12
      ]
    ]
  },
  "abstract": "<jats:p>A study was made of regeneration of skeletal muscle in young adult and old rats and of the effects of administration of growth hormone to old rats. Regeneration was achieved by subjecting the right extensor digitorum longus muscle to ischaemic necrosis. The level of insulin\u2010like growth factor I in serum was markedly decreased in old rats of 27 months of age compared with young adult rats aged 6 months. Daily injections of 4 IE recombinant human growth hormone during the 10 weeks of regeneration increased the level of insulin like growth factor I to almost the same levels as in rats aged 6 months. The body weight increased by 13% in the old rats treated with recombinant human growth hormone, while the weight of the untreated old rats was constant. The regenerating right and the normal left extensor digitorum longus muscles were studied 10 weeks after the ischaemic necrosis. The absolute and relative weights of regenerating muscle were decreased in 27\u2010month\u2010old rats compared with the rats aged 6 months. No significant difference between normal old rats and old rats treated with recombinant human growth hormone was observed either in muscle weight or in maximum contraction force. The results show that old rats have reduced levels of circulating insulin\u2010like growth factor I. Administration of recombinant human growth hormone raises the level of insulin\u2010like growth factor I to that of young adult rats, and causes an increased body weight. Muscle regeneration after ischaemic necrosis is impaired in old rats apparently by the formation of large amounts of connective tissue. Supplementation with growth hormone does not reverse this impairment.</jats:p>",
  "DOI": "10.1111/j.1748-1716.1990.tb09029.x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2008,
        12,
        9
      ]
    ],
    "date-time": "2008-12-09T18:29:07Z",
    "timestamp": 1228847347000
  },
  "page": "521-525",
  "source": "Crossref",
  "is-referenced-by-count": 29,
  "title": "Effects of growth hormone on muscle regeneration and IGF\u2010I concentration in old rats",
  "prefix": "10.1111",
  "volume": "140",
  "author": [
    {
      "given": "M.",
      "family": "ULLMAN",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "A.",
      "family": "ULLMAN",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "H.",
      "family": "SOMMERLAND",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "A.",
      "family": "SKOTTNER",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "A.",
      "family": "OLDFORS",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2008,
        12,
        8
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_1_2_1",
      "first-page": "493",
      "article-title": "Righiration musculaires par autogreffe de cellules satellites multiplites in vitro",
      "volume": "304",
      "author": "Alameddine H.",
      "year": "1987",
      "journal-title": "CR Acad Sci Paris"
    },
    {
      "key": "e_1_2_1_3_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1080/00313027109073739"
    },
    {
      "key": "e_1_2_1_4_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/ar.1091830106"
    },
    {
      "key": "e_1_2_1_5_1",
      "first-page": "113",
      "volume-title": "Clinics in Endocrinology and Metabolism",
      "author": "Clemmons D.R.",
      "year": "1984"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/jcem-51-4-781"
    },
    {
      "key": "e_1_2_1_7_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/geronj/40.1.2"
    },
    {
      "key": "e_1_2_1_8_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0024-3205(76)90280-0"
    },
    {
      "key": "e_1_2_1_9_1",
      "doi-asserted-by": "crossref",
      "first-page": "184",
      "DOI": "10.1016/S0021-9258(19)52451-6",
      "article-title": "Protein measurement with the folin phenol reagent",
      "volume": "193",
      "author": "Lowry O.H.",
      "year": "1951",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "e_1_2_1_10_1",
      "first-page": "264",
      "article-title": "Muscle regeneration. The effect of hypophysectomy on cell proliferation and expression of insulin\u2010like growth factor I",
      "volume": "78",
      "author": "Sommeland H.",
      "year": "1989",
      "journal-title": "Acta Neuropathol"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/geronj/40.6.689"
    },
    {
      "key": "e_1_2_1_12_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00584236"
    },
    {
      "key": "e_1_2_1_13_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1748-1716.1989.tb08612.x"
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1748-1716.1989.tb08613.x"
    },
    {
      "key": "e_1_2_1_15_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/mus.880050213"
    }
  ],
  "container-title": "Acta Physiologica Scandinavica",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1748-1716.1990.tb09029.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1748-1716.1990.tb09029.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        10,
        22
      ]
    ],
    "date-time": "2023-10-22T10:01:00Z",
    "timestamp": 1697968860000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1111/j.1748-1716.1990.tb09029.x"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1990,
        12
      ]
    ]
  },
  "references-count": 14,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          1990,
          12
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1111/j.1748-1716.1990.tb09029.x"
  ],
  "URL": "http://dx.doi.org/10.1111/j.1748-1716.1990.tb09029.x",
  "relation": {},
  "ISSN": [
    "0001-6772",
    "1365-201X"
  ],
  "subject": [],
  "container-title-short": "Acta Physiologica Scandinavica",
  "published": {
    "date-parts": [
      [
        1990,
        12
      ]
    ]
  }
}