DOI: 10.1111/j.1748-1716.1980.tb06557.x. Relationship between local changes in cortical blood flow and extracellular K<sup>+</sup> during spreading depression*

Relationship between local changes in cortical blood flow and extracellular K+ during spreading depression*

10.1111/j.1748-1716.1980.tb06557.x

Crossref journal-article

Wiley

Acta Physiologica Scandinavica (311)

Abstract

Change of local cerebral blood flow in response to a single cortical spreading depression of Leäo was studied in the brain. During a spreading depression, potassium briefly accumulates in the brain extracellular space. The cortical blood flow was normal during the maximal rate of increase of the extracellular potassium concentration. The blood flow doubled during the subsequent period of normalization of potassium and remained high for one minute thereafter. Thus, potassium cannot be the immediate mediator of the blood flow increase.

Bibliography

HANSEN, A. J., QUISTORFF, B., & GJEDDE, A. (1980). Relationship between local changes in cortical blood flow and extracellular K+ during spreading depression*. Acta Physiologica Scandinavica, 109(1), 1â6. Portico.

Authors 3

ANKER JON HANSEN (first)
BJØRN QUISTORFF (additional)
ALBERT GJEDDE (additional)

References 37 Referenced 122

{'key': 'e_1_2_1_2_1', 'first-page': '157', 'article-title': 'The effect of potassium on the glycolysis of brain tissue with reference to the Pasteur effect', 'volume': '29', 'author': 'Ashford C. A.', 'year': '1935', 'journal-title': 'Biochem'} / Biochem / The effect of potassium on the glycolysis of brain tissue with reference to the Pasteur effect by Ashford C. A. (1935)
10.1007/978-3-642-66427-4_23
{'key': 'e_1_2_1_4_1', 'volume-title': "The mechanism and applications of Leao's spreading depression of encephalographic activity", 'author': 'Bureŝ J.', 'year': '1974'} / The mechanism and applications of Leao's spreading depression of encephalographic activity by Bureŝ J. (1974)
{'key': 'e_1_2_1_5_1', 'first-page': '1', 'article-title': 'Changes in cerebral circulation in rats during soreading EEG depression', 'volume': '6', 'author': 'Bureŝova O.', 'year': '1957', 'journal-title': 'Physiol Bohemoslov'} / Physiol Bohemoslov / Changes in cerebral circulation in rats during soreading EEG depression by Bureŝova O. (1957)
10.1111/j.1471-4159.1968.tb10331.x
10.1111/j.1748-1716.1980.tb06540.x
Gjedde A. Hansen A. J.&Siemkowicz E.1980b.Rapid simultaneous determination of regional cerebral blood flow and blood‐brain glucose transfer in rats. In:Cerebral metabolism and neural function. Williams and Wilkins Baltimore. In press. (10.1111/j.1748-1716.1980.tb06540.x)
10.1111/j.1748-1716.1977.tb10394.x
{'key': 'e_1_2_1_10_1', 'first-page': '58', 'article-title': 'Brain extracellular ions in ischemia and spreading depression', 'volume': '473', 'author': 'Hansen A. J.', 'year': '1979', 'journal-title': 'Acta Physiol Scand'} / Acta Physiol Scand / Brain extracellular ions in ischemia and spreading depression by Hansen A. J. (1979)
{'key': 'e_1_2_1_11_1', 'first-page': '526', 'article-title': 'Effects of potassium and sodium on respiration', 'volume': '89', 'author': 'Hertz L.', 'year': '1963', 'journal-title': 'Their specificity to slices from certain brain regions. Biochem J'} / Their specificity to slices from certain brain regions. Biochem J / Effects of potassium and sodium on respiration by Hertz L. (1963)
10.1113/jphysiol.1962.sp006837
10.1016/S0021-9258(18)75097-7 / J Biol Chem / Studies of phosphorous compounds of the brain by Kerr S. E. (1935)
10.1016/0306-4522(78)90122-7
10.1152/physrev.1978.58.3.656
10.1152/jn.1944.7.6.359 / J Neurophysiol / Spreading depression of activity in cerebral cortex by Leäto A. A. P. (1944)
10.1152/jn.1944.7.6.391 / J Neurophysiol / Pial circulation and spreading depression of activity in the cerebral cortex by Leäto A. A. P. (1944)
10.1007/978-3-642-67316-0_19
10.1016/0006-8993(75)90943-9
10.1152/jn.1957.20.4.408
10.1016/0006-8993(75)90752-0
10.1073/pnas.74.3.1287
10.1111/j.1399-6576.1975.tb05408.x
10.1111/j.1471-4159.1973.tb07567.x
10.1016/0003-2697(75)90684-3
{'key': 'e_1_2_1_26_1', 'volume-title': 'Cerebral metabolism and neural function', 'author': 'Quistorff B.', 'year': '1980'} / Cerebral metabolism and neural function by Quistorff B. (1980)
{'key': 'e_1_2_1_27_1', 'first-page': '42A', 'article-title': 'Spatial analysis of the freeze trapped brain provides for temporal resolution of an event. Metabolic, electrical and blood flow changes during spreading depression', 'volume': '105', 'author': 'Quistorff B.', 'year': '1979', 'journal-title': 'Acta Physiol Scand'} / Acta Physiol Scand / Spatial analysis of the freeze trapped brain provides for temporal resolution of an event. Metabolic, electrical and blood flow changes during spreading depression by Quistorff B. (1979)
{'key': 'e_1_2_1_28_1', 'first-page': '377', 'volume-title': 'Brain work', 'author': 'Reivich M.', 'year': '1975'} / Brain work by Reivich M. (1975)
10.1152/ajplegacy.1975.228.6.1896 / Am J Physiol / Relationship between adenosine concentration and oxygen supply in rat brain by Rubio R. (1975)
10.1111/j.1471-4159.1979.tb09930.x
Sakurada O. Kennedy C. Jehle J. Brown J. D. Carbin G. L.&Sokoloff L.1978.Measurement of local cerebral blood flow with iodo[14C]antipyrine.Am J Physiol234:H59–H66. (10.1152/ajpheart.1978.234.1.H59)
10.1126/science.758688
10.1111/j.1471-4159.1977.tb10649.x
{'key': 'e_1_2_1_34_1', 'first-page': '48', 'article-title': 'Functional ablation by spreading depression: Possible use in human stereotactic neurosurgery', 'volume': '40', 'author': 'ŝRamka M.', 'year': '1977', 'journal-title': 'Appl Neurophysiol'} / Appl Neurophysiol / Functional ablation by spreading depression: Possible use in human stereotactic neurosurgery by ŝRamka M. (1977)
10.1152/ajplegacy.1957.190.3.557 / Am J Physiol / Changes in cortical pH and blood flow accompanying spreading cortical depression and convulsion by Tschirgi R. D. (1957)
10.1152/jn.1952.15.6.487 / J Neurophysiol / Vascular concomitants of spreading cortical depression by Harreveld A. (1952)
10.1152/ajplegacy.1957.189.1.159 / Am J Physiol / Electrical and vascular concomitants of spreading depression by Harreveld A. (1957)
10.1016/0006-8993(72)90802-5

Dates

Type	When
Created	16 years, 8 months ago (Dec. 9, 2008, 9:29 a.m.)
Deposited	1 year, 9 months ago (Nov. 11, 2023, 11:40 a.m.)
Indexed	2 months ago (July 2, 2025, 7:30 a.m.)
Issued	45 years, 4 months ago (May 1, 1980)
Published	45 years, 4 months ago (May 1, 1980)
Published Online	16 years, 8 months ago (Dec. 8, 2008)
Published Print	45 years, 4 months ago (May 1, 1980)

Funders 0

None

BibTeX

@article{HANSEN_1980, title={Relationship between local changes in cortical blood flow and extracellular K+ during spreading depression*}, volume={109}, ISSN={1365-201X}, url={http://dx.doi.org/10.1111/j.1748-1716.1980.tb06557.x}, DOI={10.1111/j.1748-1716.1980.tb06557.x}, number={1}, journal={Acta Physiologica Scandinavica}, publisher={Wiley}, author={HANSEN, ANKER JON and QUISTORFF, BJØRN and GJEDDE, ALBERT}, year={1980}, month=may, pages={1–6} }

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