DOI: 10.1111/j.1748-1716.1973.tb05539.x. Ionic Fluxes in the Rat Portal Vein and the Applicability of the Goldman Equation in Predicting the Membrane Potential from Flux Data

Ionic Fluxes in the Rat Portal Vein and the Applicability of the Goldman Equation in Predicting the Membrane Potential from Flux Data

10.1111/j.1748-1716.1973.tb05539.x

Crossref journal-article

Wiley

Acta Physiologica Scandinavica (311)

Abstract

AbstractWahlstrom, B. A. Ionic fluxes in the rat portal vein and the applicability of the Goldman equation in predicting the membrane potential from flux data. Acta physiol. scand. 1973. 89. 436–448.The sodium, potassium and chloride effluxes from the rat portal vein were measured using radioactive tracer ions. It was found that the sodium efflux attributable to an intracellular compartment was very slow, with a rate constant of 4.66×10‐4 s‐1, and the corresponding intracellular sodium only 3.0 mmol/kg wetweight. The intracellular potassium exchanged with a rate constant of 2.15×10‐4 s‐1 and contained 45.5 mmol/kg wetweight. The intracellular chloride content was 14.7 mmol/kg wetweight, exchanging with a rate constant of 10.55 × 10‐4 s‐1. From these data the permeabilities of Na, K and CI were calculated to 0.130, 3.81 and 3.11 ×10‐8 cms‐1 respectively. The relative permeabilities PK: PNa: PC1 were 1: 0.034: 0.816, and from these values the Goldman equation predicted a membrane potential of ‐42.3 mV. The actual membrane potential, measured by glass microelectrodes, was ‐ 45 mV. It was concluded that the membrane potential in the rat portal vein in normal solution can be predicted from the permeabilities and distribution of K and CI, while Na plays an insignificant part.

Bibliography

WahlstrÃ¶m, B. A. (1973). Ionic Fluxes in the Rat Portal Vein and the Applicability of the Goldman Equation in Predicting the Membrane Potential from Flux Data. Acta Physiologica Scandinavica, 89(3), 436â448. Portico.

Authors 1

Bo A. Wahlström (first)

References 27 Referenced 28

10.1113/jphysiol.1968.sp008496
{'key': 'e_1_2_1_3_1', 'first-page': '15', 'article-title': 'A constant flow apparatus for measuring radio‐active ion effluxes from guinea‐pig taenia coli', 'volume': '192', 'author': 'Brading A. F.', 'year': '1967', 'journal-title': 'J Physiol. (Lond.)'} / J Physiol. (Lond.) / A constant flow apparatus for measuring radio‐active ion effluxes from guinea‐pig taenia coli by Brading A. F. (1967)
10.1113/jphysiol.1971.sp009440
10.1113/jphysiol.1969.sp008700
10.1113/jphysiol.1969.sp008713
10.1113/jphysiol.1966.sp007883
10.1111/j.1476-5381.1968.tb07060.x / Brit. J. Pharamacol. / Membrane potential and ion content in cat and guinea‐pig myometrium and the response to adrenaline and noradrenaline by Bübring E. (1968)
{'key': 'e_1_2_1_9_1', 'first-page': 'C15', 'article-title': 'Ľ influence de la concentration extracellulaire du K sur la permeabilite do la membrane des fibres de Purkinje de mouton pour les ions 42K', 'volume': '18', 'author': 'Careliet E.', 'year': '1960', 'journal-title': 'Helv. physiol. Pharmacol. Acta.'} / Helv. physiol. Pharmacol. Acta. / Ľ influence de la concentration extracellulaire du K sur la permeabilite do la membrane des fibres de Purkinje de mouton pour les ions 42K by Careliet E. (1960)
{'key': 'e_1_2_1_10_1', 'first-page': '10', 'article-title': "The chloride distribution in the smooth muscle of the guinea‐pig's taenia coli", 'volume': '178', 'author': 'Casteels R.', 'year': '1965', 'journal-title': 'J. Physiol. (Lond.)'} / J. Physiol. (Lond.) / The chloride distribution in the smooth muscle of the guinea‐pig's taenia coli by Casteels R. (1965)
10.1113/jphysiol.1966.sp007907
10.1113/jphysiol.1969.sp008960
{'key': 'e_1_2_1_13_1', 'first-page': '70', 'volume-title': 'Smooth Muscle', 'author': 'Casteels R.', 'year': '1970'} / Smooth Muscle by Casteels R. (1970)
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10.1111/j.1469-185X.1951.tb01204.x
10.1113/jphysiol.1959.sp006278
{'key': 'e_1_2_1_20_1', 'first-page': '163', 'volume': '1', 'author': 'Huxley A. F.', 'year': '1960', 'journal-title': 'Mineral Metabolism'} / Mineral Metabolism by Huxley A. F. (1960)
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{'key': 'e_1_2_1_27_1', 'first-page': '63', 'article-title': 'The effects of noradrenaline on ion content and 42K and 36Cl effluxes in the rat portal vein', 'volume': '226', 'author': 'Wahlström B. A.', 'year': '1972', 'journal-title': 'J Physiol. (Lond.)'} / J Physiol. (Lond.) / The effects of noradrenaline on ion content and 42K and 36Cl effluxes in the rat portal vein by Wahlström B. A. (1972)
10.1111/j.1748-1716.1973.tb05545.x / Acta physiol. scand. / A study on the action of noradrenaline on ionic content and sodium, potassium and chloride effluxes in the rat portal vein by Wahlström B. A. (1973)

Dates

Type	When
Created	16 years, 8 months ago (Dec. 9, 2008, 5:58 a.m.)
Deposited	1 year, 9 months ago (Nov. 11, 2023, 11:43 a.m.)
Indexed	1 year, 3 months ago (May 12, 2024, 5:22 p.m.)
Issued	51 years, 10 months ago (Nov. 1, 1973)
Published	51 years, 10 months ago (Nov. 1, 1973)
Published Online	16 years, 8 months ago (Dec. 8, 2008)
Published Print	51 years, 10 months ago (Nov. 1, 1973)

Funders 0

None

BibTeX

@article{Wahlstr_m_1973, title={Ionic Fluxes in the Rat Portal Vein and the Applicability of the Goldman Equation in Predicting the Membrane Potential from Flux Data}, volume={89}, ISSN={1365-201X}, url={http://dx.doi.org/10.1111/j.1748-1716.1973.tb05539.x}, DOI={10.1111/j.1748-1716.1973.tb05539.x}, number={3}, journal={Acta Physiologica Scandinavica}, publisher={Wiley}, author={Wahlström, Bo A.}, year={1973}, month=nov, pages={436–448} }

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