DOI: 10.1111/j.1748-1716.1970.tb04642.x. The CSF/Blood Potential in Sustained Acid‐Base Changes in the Rat. With Calculations of Electrochemical Potential Differences for H+and HCO<sup>‐</sup><sub>3</sub>

The CSF/Blood Potential in Sustained Acid‐Base Changes in the Rat. With Calculations of Electrochemical Potential Differences for H+and HCO‐3

10.1111/j.1748-1716.1970.tb04642.x

Crossref journal-article

Wiley

Acta Physiologica Scandinavica (311)

Abstract

AbstractThe electrical D.C. potential difference between cisternal cerebrospinal fluid and external jugular blood was measured in rats during sustained acid‐base changes. One group, serving as a control series, was given an artificial extracellular fluid i.p., while two other groups were made acidotic or alkalotic by means of i.p. injections of NH4Cl or NaHCO3 solutions. In the last two groups NH4Cl or NaHCO3 was given, but Con was simultaneously administered so as to keep either the plasma bicarbonate or the plasma pH constant. In all groups the CSF/ plasma potential was permanently changed in relation to the arterial plasma pH, but there was a larger potential change in alkalosis (about 50 mV/pH unit) than in acidosis (about 30 mV/pH unit). Calculations of electrochemical potential differences for H+and HCO3‐between CSF and plasma showed no significant differences in nonrespiratory acidosis and alkalosis but significant increases in hypercapnia. The results do not support the theory that an active H+transport regulates the CSF pH to constancy.

Bibliography

KaÃ¤llquist, Ã. (1970). The CSF/Blood Potential in Sustained AcidâBase Changes in the Rat. With Calculations of Electrochemical Potential Differences for H+and HCOâ3. Acta Physiologica Scandinavica, 78(1), 85â93. Portico.

Authors 1

Å. Kaällquist (first)

References 23 Referenced 21

Besson J. M.andW. H.Marshall Relations between CBF and DC potential. In: “CBF & CSF” ed. byD. H.Ingvar N. A.Lassen B. K.SiesjöandE.SkinhøjScand. J. clin. Lab. Invest.1968.Sup pl. 102. I:D. (10.3109/00365516809168961)
10.1001/archneurpsyc.1942.02290060017001
{'key': 'e_1_2_1_4_1', 'first-page': '178', 'article-title': 'Effect of chronic acidosis and alkalosis on rat CSF‐blood potential', 'volume': '8', 'author': 'Goodrich C.', 'year': '1965', 'journal-title': 'Physiologist'} / Physiologist / Effect of chronic acidosis and alkalosis on rat CSF‐blood potential by Goodrich C. (1965)
10.1152/jn.1964.27.5.942 / J. Neurophysiol. / Electrical potential of cerebrospinal fluid by Held D. (1964)
10.1007/BF00631574
10.1172/JCI101995
10.1111/j.1748-1716.1967.tb03732.x
Kjällquist A.andB. K.Siesjä Regulation of CSF pH‐influence of the CSF/plasma potential. In: “CBF & CSF” ed. byD. H.Ingvar N. A.Lassen B. K.SiesjäandE.SkinhøjScand. J. clin. Lab. Invest.1968.Suppl. 102. I: C. (10.3109/00365516809168960)
{'key': 'e_1_2_1_10_1', 'first-page': '208', 'article-title': 'Respiratory response and CSF pH during disturbances in blood acid‐base balance in awake dogs with denervated aortic and carotid bodies', 'volume': '7', 'author': 'Mitchell R. A.', 'year': '1964', 'journal-title': 'Physiologist.'} / Physiologist. / Respiratory response and CSF pH during disturbances in blood acid‐base balance in awake dogs with denervated aortic and carotid bodies by Mitchell R. A. (1964)
10.1152/jappl.1965.20.3.443
10.1152/jappl.1965.20.1.27 / J. appl. Physiol. / Acid‐base constants and temperature coefficients for cerebrospinal fluid by Mitchell R. A. (1965)
10.1007/BF00363284
{'key': 'e_1_2_1_14_1', 'first-page': '247', 'volume-title': 'Cerebrospinal fluid and the regulation of ventilation', 'author': 'Severinghaus J. W.', 'year': '1965'} / Cerebrospinal fluid and the regulation of ventilation by Severinghaus J. W. (1965)
10.1152/jappl.1963.18.6.1155
10.1152/jappl.1956.9.2.197
Siesjö B. K.andA.Kjällquist Factors affecting H+ and HCO3‐in the cerebrospinal fluid. In: “CBF & CSF”. Ed. byD. H.Ingvar N. A.Lassen B. K.Siesjö; andE.Skinhøj.Scand. J. clin. Lab. Invest.1968.Suppl. 102. I: A.
Siesjö B. K.andA.Kjällquist A new theory for the regulation of the extracellular pH in the brain.Scand. J. clin. Lab. Invest.1969. In press. (10.3109/00365516909080124)
10.1007/BF00240405
10.1007/BF01895284
10.3109/00365516309079734
{'key': 'e_1_2_1_22_1', 'first-page': '154', 'article-title': 'A steady bioelectric potential between the blood and the cerebrospinal fluid (CSF)', 'volume': '13', 'author': 'Tschirgi R. D.', 'year': '1954', 'journal-title': 'Fed. Proc.'} / Fed. Proc. / A steady bioelectric potential between the blood and the cerebrospinal fluid (CSF) by Tschirgi R. D. (1954)
10.1152/ajplegacy.1958.195.1.7 / Amer. J. Physiol. / Slowly changing bioelectric potentials associated with the blood‐brain barrier by Tschirgi R. D. (1958)
Ussing H. H. Transport of electrolytes and water across epithelia.Harvey lect.1965.Senirs 59.1–30.

Dates

Type	When
Created	16 years, 8 months ago (Dec. 9, 2008, 4:18 a.m.)
Deposited	1 year, 9 months ago (Nov. 11, 2023, 7:50 a.m.)
Indexed	1 year, 3 months ago (May 12, 2024, 5:55 p.m.)
Issued	55 years, 8 months ago (Jan. 1, 1970)
Published	55 years, 8 months ago (Jan. 1, 1970)
Published Online	16 years, 8 months ago (Dec. 8, 2008)
Published Print	55 years, 8 months ago (Jan. 1, 1970)

Funders 0

None

BibTeX

@article{Ka_llquist_1970, title={The CSF/Blood Potential in Sustained Acid‐Base Changes in the Rat. With Calculations of Electrochemical Potential Differences for H+and HCO‐3}, volume={78}, ISSN={1365-201X}, url={http://dx.doi.org/10.1111/j.1748-1716.1970.tb04642.x}, DOI={10.1111/j.1748-1716.1970.tb04642.x}, number={1}, journal={Acta Physiologica Scandinavica}, publisher={Wiley}, author={Kaällquist, Å.}, year={1970}, month=jan, pages={85–93} }

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