DOI: 10.1111/j.1748-1716.1964.tb02874.x. Cellular Localization of Monoamines in the Spinal Cord

Cellular Localization of Monoamines in the Spinal Cord

10.1111/j.1748-1716.1964.tb02874.x

Crossref journal-article

Wiley

Acta Physiologica Scandinavica (311)

Abstract

AbstractThe cellular localization of monoamines in the spinal cord of the mouse and the rat has been studied with the use of a fluorescence method for histochemical demonstration of certain cate‐cholamines and tryptamines in combination with a pharmacological approach and transection experiments. Strong evidence was obtained for the view that noradrenaline (NA) and 5‐hydroxytryptamine (5‐HT) are localized in special systems of nerve tracts which from supraspinal centers descend in the lateral and anterior funiculi to terminate in the gray matter and which belong to monoaminergic neurons. The amines show a massive accumulation in the terminal part of the nerve fibres. This strongly indicates that both amines serve as synaptic transmitters in the spinal cord. Many nerve terminals containing NA or 5‐HT are present in the anterior horns. They are more scarce in the posterior horns. Terminals of both kinds are highly concentrated in the sympathetic lateral column where most—if not all—of the nerve cells are surrounded by them. They originate—at least mainly—from a tract descending in the dorsolateral funiculi. This localization of the descending fibres suggests that they arc identical with the inhibitory fibres going to the sympathetic column.

Bibliography

Carlsson, A., Falck, B., Fuxe, K., & Hillarp, N. (1964). Cellular Localization of Monoamines in the Spinal Cord. Acta Physiologica Scandinavica, 60(1â2), 112â119. Portico.

Authors 4

Arvid Carlsson (first)
Bengt Falck (additional)
Kjell Fuxe (additional)
Nils‐Åre Hillarp (additional)

References 18 Referenced 448

10.1152/jn.1946.9.3.205 / J. Neurophysiol. / Tonic and reflex functions of medullary sympathetic cardiovascular centers. by ALEXANDER R. S. (1946)
ANDÉN N. E. J.HÄGGENDAL T.MAGNUSSONandE.ROSENGREN 1963.Unpubl. data.
{'issue': '196', 'key': 'e_1_2_1_4_1', 'article-title': 'Cellular localization of brain monoamines.', 'volume': '56', 'author': 'CARLSSON A.', 'year': '1962', 'journal-title': 'Acta physiol. scand.'} / Acta physiol. scand. / Cellular localization of brain monoamines. by CARLSSON A. (1962)
10.1111/j.1748-1716.1962.tb02364.x
10.1111/j.1748-1716.1962.tb02331.x
10.1007/BF02152316
{'key': 'e_1_2_1_8_1', 'article-title': 'Sensitive fluorescence methods for histochemical demonstrations of catecholamines at the cellular level. Paper read at Scand. pharmacol', 'author': 'CORRODI H.', 'year': '1962', 'journal-title': 'Meeting. Göteborg'} / Meeting. Göteborg / Sensitive fluorescence methods for histochemical demonstrations of catecholamines at the cellular level. Paper read at Scand. pharmacol by CORRODI H. (1962)
10.1016/S0022-5320(63)80049-0
{'key': 'e_1_2_1_10_1', 'volume-title': 'Noradrenaline', 'author': 'EULER U. S. v.', 'year': '1956'} / Noradrenaline by EULER U. S. v. (1956)
{'key': 'e_1_2_1_11_1', 'first-page': '43', 'article-title': 'Neutrotransmission in the adrenergic nervous system.', 'volume': '55', 'author': 'EULER U. S. v.', 'year': '1961', 'journal-title': 'Harvey Lect.'} / Harvey Lect. / Neutrotransmission in the adrenergic nervous system. by EULER U. S. v. (1961)
{'issue': '197', 'key': 'e_1_2_1_12_1', 'article-title': 'Observations on the possibilities of the cellular localization of monoamines by a fluorescence method.', 'volume': '56', 'author': 'FALCK B.', 'year': '1962', 'journal-title': 'Acta physiol. scand.'} / Acta physiol. scand. / Observations on the possibilities of the cellular localization of monoamines by a fluorescence method. by FALCK B. (1962)
10.1177/10.3.348
{'key': 'e_1_2_1_14_1', 'volume-title': 'Nervous Inhibition. Proc. 2nd Friday Harbor Symp', 'author': 'FLOREY E.', 'year': '1961'} / Nervous Inhibition. Proc. 2nd Friday Harbor Symp by FLOREY E. (1961)
10.1093/icb/2.1.45 / Amer. Zoologist / Recent studies on synaptic transmitters. by FLOREY E. (1962)
{'key': 'e_1_2_1_16_1', 'article-title': 'Structure of the synaise and the peripheral innervation apparatus of the autonomic nervous system', 'author': 'HILLARP N.‐Å.', 'year': '1946', 'journal-title': 'Acta anat. (Basel)'} / Acta anat. (Basel) / Structure of the synaise and the peripheral innervation apparatus of the autonomic nervous system by HILLARP N.‐Å. (1946)
{'key': 'e_1_2_1_17_1', 'first-page': '61', 'article-title': 'On the question of a myelencephalic sympathetic centre.', 'volume': '13', 'author': 'LIM R. K. S.', 'year': '1938', 'journal-title': 'Chinese J. Physiol.'} / Chinese J. Physiol. / On the question of a myelencephalic sympathetic centre. by LIM R. K. S. (1938)
10.1007/BF02151349
{'key': 'e_1_2_1_19_1', 'first-page': '1131', 'volume-title': 'Handbook of Physiology, Neurophysiology II.', 'author': 'UVNÄS B.', 'year': '1960'} / Handbook of Physiology, Neurophysiology II. by UVNÄS B. (1960)

Dates

Type	When
Created	16 years, 8 months ago (Dec. 8, 2008, 10:39 p.m.)
Deposited	2 years ago (Aug. 31, 2023, 12:55 a.m.)
Indexed	1 month ago (July 30, 2025, 10:42 a.m.)
Issued	61 years, 8 months ago (Jan. 1, 1964)
Published	61 years, 8 months ago (Jan. 1, 1964)
Published Online	16 years, 8 months ago (Dec. 8, 2008)
Published Print	61 years, 8 months ago (Jan. 1, 1964)

Funders 0

None

BibTeX

@article{Carlsson_1964, title={Cellular Localization of Monoamines in the Spinal Cord}, volume={60}, ISSN={1365-201X}, url={http://dx.doi.org/10.1111/j.1748-1716.1964.tb02874.x}, DOI={10.1111/j.1748-1716.1964.tb02874.x}, number={1–2}, journal={Acta Physiologica Scandinavica}, publisher={Wiley}, author={Carlsson, Arvid and Falck, Bengt and Fuxe, Kjell and Hillarp, Nils‐Åre}, year={1964}, month=jan, pages={112–119} }

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