DOI: 10.1111/j.1742-4658.2007.06094.x. <i>Saccharomyces cerevisiae</i> Cox18 complements the essential Sec‐independent function of <i>Escherichia coli</i> YidC

Saccharomyces cerevisiae Cox18 complements the essential Sec‐independent function of Escherichia coli YidC

10.1111/j.1742-4658.2007.06094.x

Crossref journal-article

Wiley

The FEBS Journal (311)

Abstract

Members of the YidC/Oxa1/Alb3 protein family function in the biogenesis of membrane proteins in bacteria, mitochondria and chloroplasts. In Escherichia coli, YidC plays a key role in the integration and assembly of many inner membrane proteins. Interestingly, YidC functions both in concert with the Sec‐translocon and as a separate insertase independent of the translocon. Mitochondria of higher eukaryotes contain two distant homologues of YidC: Oxa1 and Cox18/Oxa2. Oxa1 is required for the insertion of membrane proteins into the mitochondrial inner membrane. Cox18/Oxa2 plays a poorly defined role in the biogenesis of the cytochrome c oxidase complex. Employing a genetic complementation approach by expressing the conserved region of yeast Cox18 in E. coli, we show here that Cox18 is able to complement the essential Sec‐independent function of YidC. This identifies Cox18 as a bona fide member of the YidC/Oxa1/Alb3 family.

Bibliography

van Bloois, E., Koningstein, G., Bauerschmitt, H., Herrmann, J. M., & Luirink, J. (2007). Saccharomyces cerevisiae Cox18 complements the essential Secâindependent function of Escherichia coli YidC. The FEBS Journal, 274(21), 5704â5713. Portico.

Authors 5

Edwin van Bloois (first)
Gregory Koningstein (additional)
Heike Bauerschmitt (additional)
Johannes M. Herrmann (additional)
Joen Luirink (additional)

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Dates

Type	When
Created	17 years, 10 months ago (Oct. 8, 2007, 9:32 a.m.)
Deposited	1 year, 9 months ago (Oct. 31, 2023, 3:11 a.m.)
Indexed	4 days, 14 hours ago (Aug. 20, 2025, 8:45 a.m.)
Issued	17 years, 10 months ago (Oct. 8, 2007)
Published	17 years, 10 months ago (Oct. 8, 2007)
Published Online	17 years, 10 months ago (Oct. 8, 2007)
Published Print	17 years, 9 months ago (Nov. 1, 2007)

Funders 0

None

BibTeX

@article{van_Bloois_2007, title={Saccharomyces cerevisiae Cox18 complements the essential Sec‐independent function of Escherichia coli YidC}, volume={274}, ISSN={1742-4658}, url={http://dx.doi.org/10.1111/j.1742-4658.2007.06094.x}, DOI={10.1111/j.1742-4658.2007.06094.x}, number={21}, journal={The FEBS Journal}, publisher={Wiley}, author={van Bloois, Edwin and Koningstein, Gregory and Bauerschmitt, Heike and Herrmann, Johannes M. and Luirink, Joen}, year={2007}, month=oct, pages={5704–5713} }

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