DOI: 10.1111/j.1651-2227.1985.tb10019.x. NON‐IgE‐MEDIATED ASTHMA IN CHILDREN

10.1111/j.1651-2227.1985.tb10019.x

Crossref journal-article

Wiley

Acta Paediatrica (311)

Abstract

ABSTRACT. Among 586 children with asthma, 484 (82 %) were found to have IgE‐mediated (“extrinsic”) asthma, and seventy‐two (12 %) non‐IgE (“intrinsic”) asthma. The remaining 30 patients (6%) were classified as “intermediate”, as they had serum IgE within or above serum IgE levels of healthy children but no allergy to common allergens. During a three‐year study period, the seventy‐two patients with intrinsic asthma as opposed to 84 patients with extrinsic asthma had significantly 1) more hyperinflation of the lungs, 2) more episodes of acute hospital admissions due to asthma and/or pneumonia, 3) more elevated serum IgG and IgM, and 4) more cultures from secretions of lower airways of Haemophilus influenzae and pneumococci. Further, although treated with corticosteroids, eleven of the children with intrinsic asthma showed progressive disease, judged from fixed and/or declining forced vital capacity followed by signs of lung fibrosis on repeated pulmonary X‐rays. It is emphasized that children with intrinsic asthma may represent an entity of childhood asthma, in some cases with severe progression of disease within a few years.

Bibliography

ÃSTERGAARD, P. AA. (1985). NONâIgEâMEDIATED ASTHMA IN CHILDREN. Acta Paediatrica, 74(5), 713â719. Portico.

Authors 1

P. AA. ØSTERGAARD (first)

References 14 Referenced 26

10.1136/bmj.280.6229.1397
10.1136/bmj.4.5883.7
ØstergaardPAa.Extrinsic allergisk asthma hos børn. Ugeskr Læg (to be published).
{'key': 'e_1_2_1_5_2', 'first-page': '535', 'article-title': 'A research standard for human serum immunoglobulins IgG, IgA and IgM', 'volume': '42', 'author': 'Rowe DS', 'year': '1972', 'journal-title': 'Bull WHO'} / Bull WHO / A research standard for human serum immunoglobulins IgG, IgA and IgM by Rowe DS (1972)
{'key': 'e_1_2_1_6_2', 'first-page': '290', 'article-title': 'IgA levels and carrier rate of Haemophilus influenzae and beta‐haemolytic streptococci in children undergoing tonsillectomy', 'volume': '84', 'author': 'Østergaard PAa.', 'year': '1976', 'journal-title': 'Acta Pathol Microbiol Scand'} / Acta Pathol Microbiol Scand / IgA levels and carrier rate of Haemophilus influenzae and beta‐haemolytic streptococci in children undergoing tonsillectomy by Østergaard PAa. (1976)
10.3109/00365516809077006
WeekeB.Aluminium hydroxide absorbed allergens used in a modified RAST (Al‐RAST).Allergol Immunopathol1977;333.
10.1111/j.1398-9995.1982.tb01880.x
10.1159/000232981
{'key': 'e_1_2_1_11_2', 'first-page': '1', 'volume-title': 'Asthma', 'author': 'Scadding JG.', 'year': '1983'} / Asthma by Scadding JG. (1983)
10.1136/bmj.282.6274.1419
{'key': 'e_1_2_1_13_2', 'first-page': '347', 'article-title': 'Hyper‐IgM immunoglobulinemia in children with bronchial asthma', 'volume': '102', 'author': 'Lin MS', 'year': '1977', 'journal-title': 'J Pediatr'} / J Pediatr / Hyper‐IgM immunoglobulinemia in children with bronchial asthma by Lin MS (1977)
10.1016/S0022-3476(82)80005-X
10.1111/j.1365-2222.1982.tb02553.x

Dates

Type	When
Created	17 years, 7 months ago (Jan. 21, 2008, 3:03 p.m.)
Deposited	1 year, 10 months ago (Oct. 19, 2023, 9:33 p.m.)
Indexed	1 year, 10 months ago (Oct. 24, 2023, 1:06 p.m.)
Issued	39 years, 11 months ago (Sept. 1, 1985)
Published	39 years, 11 months ago (Sept. 1, 1985)
Published Online	17 years, 7 months ago (Jan. 21, 2008)
Published Print	39 years, 11 months ago (Sept. 1, 1985)

Funders 0

None

BibTeX

@article{_STERGAARD_1985, title={NON‐IgE‐MEDIATED ASTHMA IN CHILDREN}, volume={74}, ISSN={1651-2227}, url={http://dx.doi.org/10.1111/j.1651-2227.1985.tb10019.x}, DOI={10.1111/j.1651-2227.1985.tb10019.x}, number={5}, journal={Acta Paediatrica}, publisher={Wiley}, author={ØSTERGAARD, P. AA.}, year={1985}, month=sep, pages={713–719} }

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