DOI: 10.1111/j.1600-079x.1997.tb00331.x. Melatonin prevents increases in neural nitric oxide and cyclic GMP production after transient brain ischemia and reperfusion in the Mongolian gerbil (<i>Meriones Unguiculatus</i>)

Melatonin prevents increases in neural nitric oxide and cyclic GMP production after transient brain ischemia and reperfusion in the Mongolian gerbil (Meriones Unguiculatus)

10.1111/j.1600-079x.1997.tb00331.x

Crossref journal-article

Wiley

Journal of Pineal Research (311)

Abstract

ABSTRACT: While nitric oxide (NO) has been implicated as a mediator of glutamate excitotoxicity after cerebral ischemia/reperfusion, melatonin has been reported to inhibit brain NO production by suppressing nitric oxide synthase. The purpose of the present studies was to determine the effect of exogenous melatonin administration on NO‐induced changes during brain ischemia/reperfusion. Indicators of cerebral cortical and cerebellar NO production [nitrite/nitrate levels and cyclic guanosine monophosphate(cGMP)] were used to estimate neural changes after transient bilateral carotid artery ligation followed by reperfusion in adult Mongolian gerbils (Meriones unguiculatus). Results show for the first time that melatonin prevents the increases in NO and cGMP production after transient ischemia/reperfusion in frontal cerebral cortex and cerebellum of Mongolian gerbils. The inhibitory effect of melatonin on NO production and its ability to scavenge free radicals and the peroxynitrite anion may be responsible for the protective effect of melatonin on neuronal structures during transient ischemia followed by reperfusion.

Bibliography

Guerrero, J. M., Reiter, R. J., Ortiz, G. G., Pablos, M. I., Sewerynek, E., & Chuang, J. (1997). Melatonin prevents increases in neural nitric oxide and cyclic GMP production after transient brain ischemia and reperfusion in the Mongolian gerbil (Meriones Unguiculatus). Journal of Pineal Research, 23(1), 24â31. Portico.

Authors 6

Juan M. Guerrero (first)
Russel J. Reiter (additional)
Genaro G. Ortiz (additional)
Marta I. Pablos (additional)
Ewa Sewerynek (additional)
Jih‐lng Chuang (additional)

References 50 Referenced 77

10.1111/j.1600-079X.1995.tb00171.x
10.1111/j.1600-079X.1990.tb00709.x
10.1016/0006-8993(91)90146-M
10.1016/0024-3205(93)90670-X
10.1111/j.1600-079X.1996.tb00260.x
10.1073/pnas.86.22.9030
10.1073/pnas.87.2.682
10.1016/S0021-9258(19)49862-1 / J. Biol. Chem. / Nitric oxide synthase regulatory sites: Phosphorylation by cyclic AMP dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase by Bredt D.S. (1992)
10.1111/j.1471-4159.1993.tb02174.x
10.1111/j.1600-079X.1995.tb00163.x
10.1146/annurev.ne.13.030190.001131
10.1016/0166-2236(87)90175-5
10.1111/j.1600-079X.1995.tb00180.x
10.1073/pnas.88.14.6368
10.1016/S0021-9258(18)41847-9 / J. Biol. Chem. / Nitric oxide causes ADP‐ribosylation and inhibition of glyceraldehyde‐3‐phos‐phate dehydrogenase by Dimmler S.F. (1992)
10.1161/01.STR.25.3.692
10.1016/S0024-3205(97)00008-8
10.1016/0197-0186(95)00162-X
10.1111/j.1600-079X.1995.tb00147.x
10.1016/S0076-6879(94)33028-X
10.1126/science.7522345
10.1111/j.1600-079X.1994.tb00114.x
10.1161/01.STR.24.11.1709
10.1227/00006123-199408000-00013
10.1111/j.1600-079X.1997.tb00317.x
10.1097/00001756-199609020-00003
10.1096/fasebj.10.13.8940301 / FASEB J. / Increased brain damage after stroke or excitotoxic seizures in melato‐nin‐deficient rats by Manev H. (1996)
10.1016/0165-6147(90)90184-A
10.1111/j.1600-079X.1993.tb00511.x
10.1016/0006-291X(77)91460-7
10.1016/0304-3940(92)90584-T
10.1016/0014-2999(91)90862-K
10.1523/JNEUROSCI.17-05-01683.1997
10.1111/j.1600-079X.1993.tb00498.x
10.1080/13510002.1996.11747046
10.1016/0024-3205(94)00532-X
10.1002/(SICI)1097-4644(19970601)65:3<430::AID-JCB12>3.0.CO;2-J
{'key': 'e_1_2_1_39_1', 'first-page': 'L699', 'article-title': 'The chemistry of peroxyni‐trite: A product from the reaction of nitric oxide with superoxide', 'volume': '268', 'author': 'Pryor W.', 'year': '1995', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. / The chemistry of peroxyni‐trite: A product from the reaction of nitric oxide with superoxide by Pryor W. (1995)
10.1016/S0021-9258(20)64313-7 / J. Biol. Chem. / Per‐oxynitrite oxidation of sulphydryls by Radi R. (1991)
10.1096/fasebj.9.7.7737461 / FASEB J. / Oxidative processes and antioxidative defense mechanisms in the aging brain by Reiter R.J. (1995)
10.1016/S1054-3589(08)60981-3
10.1111/j.1600-079X.1995.tb00133.x
{'key': 'e_1_2_1_44_1', 'first-page': '898', 'article-title': 'Oxidative damage in the liver induced by is‐chemia‐reperfusion: Protection by melatonin', 'volume': '43', 'author': 'Sewerynek E.', 'year': '1996', 'journal-title': 'Hepato Gastroenterology'} / Hepato Gastroenterology / Oxidative damage in the liver induced by is‐chemia‐reperfusion: Protection by melatonin by Sewerynek E. (1996)
10.1111/j.1600-079X.1994.tb00102.x
10.1152/ajpcell.1991.260.5.C910
10.1097/00024382-199608000-00001
{'key': 'e_1_2_1_48_1', 'first-page': '57', 'article-title': 'Melatonin: A potent, endogenous hydroxyl radical scavenger', 'volume': '1', 'author': 'Tan D.X.', 'year': '1993', 'journal-title': 'Endocr. J.'} / Endocr. J. / Melatonin: A potent, endogenous hydroxyl radical scavenger by Tan D.X. (1993)
10.1016/0166-2236(87)90171-8
10.1126/science.1948068
10.1111/j.1600-079X.1996.tb00277.x

Dates

Type	When
Created	18 years, 7 months ago (Feb. 2, 2007, 5:23 p.m.)
Deposited	1 year, 10 months ago (Oct. 27, 2023, 5:48 p.m.)
Indexed	1 year, 2 months ago (June 11, 2024, 8:32 a.m.)
Issued	28 years, 1 month ago (Aug. 1, 1997)
Published	28 years, 1 month ago (Aug. 1, 1997)
Published Online	18 years, 7 months ago (Jan. 30, 2007)
Published Print	28 years, 1 month ago (Aug. 1, 1997)

Funders 0

None

BibTeX

@article{Guerrero_1997, title={Melatonin prevents increases in neural nitric oxide and cyclic GMP production after transient brain ischemia and reperfusion in the Mongolian gerbil (Meriones Unguiculatus)}, volume={23}, ISSN={1600-079X}, url={http://dx.doi.org/10.1111/j.1600-079x.1997.tb00331.x}, DOI={10.1111/j.1600-079x.1997.tb00331.x}, number={1}, journal={Journal of Pineal Research}, publisher={Wiley}, author={Guerrero, Juan M. and Reiter, Russel J. and Ortiz, Genaro G. and Pablos, Marta I. and Sewerynek, Ewa and Chuang, Jih‐lng}, year={1997}, month=aug, pages={24–31} }

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