DOI: 10.1111/j.1600-079x.1991.tb00827.x. Melatonin‐induced enhancement of antibody‐dependent cellular cytotoxicity

Melatonin‐induced enhancement of antibody‐dependent cellular cytotoxicity

10.1111/j.1600-079x.1991.tb00827.x

Crossref journal-article

Wiley

Journal of Pineal Research (311)

Abstract

Abstract: Antibody‐dependent cellular cytotoxicity (ADCC) is a lytic mechanism in which a specific antibody acts cooperatively with leukocytic effector cells to induce target cell lysis. In this paper, the effect of exogenous melatonin on ADCC was examined. It was found that two evening intravenous injections of melatonin (1 mg/kg b.w.) was sufficient to enhance the capacity of splenocytes to mediate ADCC. This augmented activity returned to normal levels by day 6. Moreover, the opioid antagonist, naloxone, was unable to inhibit the ADCC enhancement, suggesting that melatonin did not operate through a naloxone‐sensitive opiatergic mechanism. These results further support the modulatory action of melatonin on immune responses.

Bibliography

Giordano, M., & Palermo, M. S. (1991). Melatoninâinduced enhancement of antibodyâdependent cellular cytotoxicity. Journal of Pineal Research, 10(3), 117â121. Portico.

Authors 2

Mirta Giordano (first)
Marina S. Palermo (additional)

References 18 Referenced 53

10.1073/pnas.81.11.3506
10.1016/0192-0561(89)90187-2
10.1016/S0065-2776(08)60330-2
10.1016/0167-5699(89)90234-X
{'key': 'e_1_2_1_5_1', 'first-page': '103', 'volume-title': 'Spontaneous and rIFN‐induced human natural killer (NK) cell activity after acute melatonin administration. Abstracts from the Ninth European Immunology Meeting', 'author': 'Gatti G.', 'year': '1988'} / Spontaneous and rIFN‐induced human natural killer (NK) cell activity after acute melatonin administration. Abstracts from the Ninth European Immunology Meeting by Gatti G. (1988)
10.1007/BF01311092
10.1126/science.224457
{'key': 'e_1_2_1_8_1', 'first-page': '1', 'article-title': 'Effect of pinealectomy on immune reactions in the rat', 'volume': '18', 'author': 'Jankovic B.D.', 'year': '1970', 'journal-title': 'Immunology'} / Immunology / Effect of pinealectomy on immune reactions in the rat by Jankovic B.D. (1970)
{'key': 'e_1_2_1_9_1', 'first-page': '405', 'volume-title': 'Psychoneuroimmunology', 'author': 'Maestroni G.J.M.', 'year': '1981'} / Psychoneuroimmunology by Maestroni G.J.M. (1981)
{'key': 'e_1_2_1_10_1', 'first-page': '384', 'article-title': 'Role of the pineal gland in immunity. II. Melatonin enhances the antibody response via an opiatergic mechanism', 'volume': '68', 'author': 'Maestroni G.J.M.', 'year': '1987', 'journal-title': 'Clin. Exp. Immunol.'} / Clin. Exp. Immunol. / Role of the pineal gland in immunity. II. Melatonin enhances the antibody response via an opiatergic mechanism by Maestroni G.J.M. (1987)
10.1111/j.1749-6632.1987.tb35747.x
10.1016/0014-5793(88)81293-6
10.1038/259403a0
10.1084/jem.152.1.198
10.1084/jem.158.3.670
10.1210/endo-98-6-1418
10.1016/0008-8749(70)90051-1
10.1084/jem.157.6.1828

Dates

Type	When
Created	18 years, 7 months ago (Feb. 2, 2007, 5:05 p.m.)
Deposited	1 year, 10 months ago (Oct. 22, 2023, 5:17 p.m.)
Indexed	1 month, 1 week ago (July 24, 2025, 7:26 a.m.)
Issued	34 years, 5 months ago (April 1, 1991)
Published	34 years, 5 months ago (April 1, 1991)
Published Online	18 years, 7 months ago (Jan. 30, 2007)
Published Print	34 years, 5 months ago (April 1, 1991)

Funders 0

None

BibTeX

@article{Giordano_1991, title={Melatonin‐induced enhancement of antibody‐dependent cellular cytotoxicity}, volume={10}, ISSN={1600-079X}, url={http://dx.doi.org/10.1111/j.1600-079x.1991.tb00827.x}, DOI={10.1111/j.1600-079x.1991.tb00827.x}, number={3}, journal={Journal of Pineal Research}, publisher={Wiley}, author={Giordano, Mirta and Palermo, Marina S.}, year={1991}, month=apr, pages={117–121} }

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