DOI: 10.1111/j.1600-0773.1987.tb01730.x. The Effect of Mercury Chloride and Methyl Mercury on Brain Microsomal Na<sup>+</sup>‐K<sup>+</sup>‐ATPase after Partial Delipidisation with Lubrol®

The Effect of Mercury Chloride and Methyl Mercury on Brain Microsomal Na+‐K+‐ATPase after Partial Delipidisation with Lubrol®

10.1111/j.1600-0773.1987.tb01730.x

Crossref journal-article

Wiley

Pharmacology & Toxicology (311)

Abstract

Abstract: The microsomal Na+‐K+‐ATPase of rat brain was inhibited by mercury chloride and methyl mercury. The IC50 was 6.5 × 10‐7 M for mercury chloride and 3.5 × 10‐6 M for methyl mercury. The inhibition was of a non‐competetive type with respect to ATP. The non‐ionic detergent Lubrol$rG potentiated the inhibitory effect of both mercurials. It is concluded that Lubrol$rG removes the bulk lipids present outside the catalytic center of the enzyme. Consequently, the enzyme will become more sensitive to the inhibition by both mercurials.

Bibliography

Magour, S., MÃ¤ser, H., & Greim, H. (1987). The Effect of Mercury Chloride and Methyl Mercury on Brain Microsomal Na+âK+âATPase after Partial Delipidisation with LubrolÂ®. Pharmacology & Toxicology, 60(3), 184â186. Portico.

Authors 3

S. Magour (first)
H. Mäser (additional)
H. Greim (additional)

References 10 Referenced 22

10.1016/0005-2736(67)90007-7
10.1007/BF00343125
{'key': 'e_1_2_1_4_1', 'first-page': '409', 'volume-title': 'Toxicology: The basic science of poisons.', 'author': 'Hammond P. B.', 'year': '1980'} / Toxicology: The basic science of poisons. by Hammond P. B. (1980)
10.1016/0304-4157(82)90013-2
10.1016/0005-2736(71)90334-8
10.1016/S0021-9258(19)52451-6
10.1016/0024-3205(76)90336-2
10.1016/0013-9351(81)90214-0
10.1111/j.1600-0773.1984.tb01934.x
10.1111/j.1471-4159.1970.tb06871.x

Dates

Type	When
Created	16 years, 5 months ago (March 25, 2009, 2:28 p.m.)
Deposited	1 year, 10 months ago (Oct. 20, 2023, 11:38 p.m.)
Indexed	1 year, 2 months ago (June 18, 2024, 4:31 p.m.)
Issued	38 years, 6 months ago (March 1, 1987)
Published	38 years, 6 months ago (March 1, 1987)
Published Online	16 years, 5 months ago (March 25, 2009)
Published Print	38 years, 6 months ago (March 1, 1987)

Funders 0

None

BibTeX

@article{Magour_1987, title={The Effect of Mercury Chloride and Methyl Mercury on Brain Microsomal Na+‐K+‐ATPase after Partial Delipidisation with Lubrol®}, volume={60}, ISSN={0901-9928}, url={http://dx.doi.org/10.1111/j.1600-0773.1987.tb01730.x}, DOI={10.1111/j.1600-0773.1987.tb01730.x}, number={3}, journal={Pharmacology & Toxicology}, publisher={Wiley}, author={Magour, S. and Mäser, H. and Greim, H.}, year={1987}, month=mar, pages={184–186} }

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