DOI: 10.1111/j.1600-0676.1982.tb00178.x. The pathology of hepatitis A in man

10.1111/j.1600-0676.1982.tb00178.x

Crossref journal-article

Wiley

Liver (311)

Abstract

ABSTRACT— Liver biopsies from 17 patients with serologically established hepatitis A were examined by light microscopy. Biopsies were taken from 2 to 27 weeks after onset of symptoms. All showed acute hepatitis, usually with centrilobular lesions but also commonly with a striking portal and periportal inflammatory reaction, resembling that seen in chronic active hepatitis. The infiltrate was rich in plasma cells. Centrilobular cholestasis was common and occasionally severe. Neither cholestasis nor the periportal lesion appeared to be related to patient age or to the timing of liver biopsy. All patients made a full recovery and none developed chronic liver disease. The histological changes differed from those reported in children and in chimpanzees in the presence of centrilobular lesions, but resembled them in that the latter two groups also had periportal lesions. These lesions may lead to a false impression of impending chronicity if the aetiology of the hepatitis is not known at the time of liver biopsy.

Bibliography

Teixeira, M. R., Weller, I. V. D., Murray, A., Bamber, M., Thomas, H. C., Sherlock, S., & Scheuer, P. J. (1982). The pathology of hepatitis A in man. Liver, 2(1), 53â60. Portico.

Authors 7

M. R. Teixeira (first)
I. V. D. Weller (additional)
A. Murray (additional)
M. Bamber (additional)
H. C. Thomas (additional)
S. Sherlock (additional)
P. J. Scheuer (additional)

References 13 Referenced 87

10.1016/S0140-6736(00)87419-X
10.1136/jcp.25.10.850
{'key': 'e_1_2_1_4_2', 'first-page': '787', 'article-title': 'Light microscopic morphology of viral hepatitis', 'volume': '65', 'author': 'Ishak K G.', 'year': '1976', 'journal-title': 'Amer J Clin Pathol'} / Amer J Clin Pathol / Light microscopic morphology of viral hepatitis by Ishak K G. (1976)
{'key': 'e_1_2_1_5_2', 'first-page': '164', 'volume-title': 'Pathology of the liver', 'author': 'Bianchi L.', 'year': '1979'} / Pathology of the liver by Bianchi L. (1979)
10.1001/jama.1970.03180060019004 / JAMA / Viral hepatitis. Clinical and tissue culture studies by Boggs J D (1970)
{'key': 'e_1_2_1_7_2', 'first-page': '168', 'article-title': 'Acute viral hepatitis. Type A hepatitis. Its epidemiology, clinical pictures and pathologic changes of the liver', 'volume': '14', 'author': 'Tanikawa K.', 'year': '1979', 'journal-title': 'Gastroenterol Jpn'} / Gastroenterol Jpn / Acute viral hepatitis. Type A hepatitis. Its epidemiology, clinical pictures and pathologic changes of the liver by Tanikawa K. (1979)
10.2957/kanzo.22.22
10.1093/infdis/132.5.532
{'key': 'e_1_2_1_10_2', 'first-page': '131', 'article-title': 'The pathology of viral hepatitis types A and B in chimpanzees. A comparison', 'volume': '85', 'author': 'Dienstag J L', 'year': '1976', 'journal-title': 'Am J Pathol'} / Am J Pathol / The pathology of viral hepatitis types A and B in chimpanzees. A comparison by Dienstag J L (1976)
10.1007/BF00428432
{'key': 'e_1_2_1_12_2', 'first-page': '333', 'article-title': 'Morphologial criteria in viral hepatitis', 'author': 'International Group.', 'year': '1971', 'journal-title': 'Lancet'} / Lancet / Morphologial criteria in viral hepatitis by International Group. (1971)
10.1136/bmj.1.5083.1315
10.3181/00379727-135-35049

Dates

Type	When
Created	15 years ago (Aug. 10, 2010, 3:57 p.m.)
Deposited	1 year, 9 months ago (Nov. 8, 2023, 11:31 a.m.)
Indexed	1 month, 1 week ago (July 30, 2025, 11:33 a.m.)
Issued	43 years, 6 months ago (March 1, 1982)
Published	43 years, 6 months ago (March 1, 1982)
Published Online	16 years, 8 months ago (Dec. 10, 2008)
Published Print	43 years, 6 months ago (March 1, 1982)

Funders 0

None

BibTeX

@article{Teixeira_1982, title={The pathology of hepatitis A in man}, volume={2}, ISSN={1600-0676}, url={http://dx.doi.org/10.1111/j.1600-0676.1982.tb00178.x}, DOI={10.1111/j.1600-0676.1982.tb00178.x}, number={1}, journal={Liver}, publisher={Wiley}, author={Teixeira, M. R. and Weller, I. V. D. and Murray, A. and Bamber, M. and Thomas, H. C. and Sherlock, S. and Scheuer, P. J.}, year={1982}, month=mar, pages={53–60} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        30
      ]
    ],
    "date-time": "2025-07-30T15:33:30Z",
    "timestamp": 1753889610350
  },
  "reference-count": 13,
  "publisher": "Wiley",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2008,
            12,
            10
          ]
        ],
        "date-time": "2008-12-10T00:00:00Z",
        "timestamp": 1228867200000
      },
      "content-version": "vor",
      "delay-in-days": 9781,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1982,
        3
      ]
    ]
  },
  "abstract": "<jats:p><jats:bold>ABSTRACT\u2014</jats:bold> Liver biopsies from 17 patients with serologically established hepatitis A were examined by light microscopy. Biopsies were taken from 2 to 27 weeks after onset of symptoms. All showed acute hepatitis, usually with centrilobular lesions but also commonly with a striking portal and periportal inflammatory reaction, resembling that seen in chronic active hepatitis. The infiltrate was rich in plasma cells. Centrilobular cholestasis was common and occasionally severe. Neither cholestasis nor the periportal lesion appeared to be related to patient age or to the timing of liver biopsy. All patients made a full recovery and none developed chronic liver disease. The histological changes differed from those reported in children and in chimpanzees in the presence of centrilobular lesions, but resembled them in that the latter two groups also had periportal lesions. These lesions may lead to a false impression of impending chronicity if the aetiology of the hepatitis is not known at the time of liver biopsy.</jats:p>",
  "DOI": "10.1111/j.1600-0676.1982.tb00178.x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2010,
        8,
        10
      ]
    ],
    "date-time": "2010-08-10T19:57:43Z",
    "timestamp": 1281470263000
  },
  "page": "53-60",
  "source": "Crossref",
  "is-referenced-by-count": 87,
  "title": "The pathology of hepatitis A in man",
  "prefix": "10.1111",
  "volume": "2",
  "author": [
    {
      "suffix": "Jr.",
      "given": "M. R.",
      "family": "Teixeira",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "I. V. D.",
      "family": "Weller",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "A.",
      "family": "Murray",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "M.",
      "family": "Bamber",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "H. C.",
      "family": "Thomas",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "S.",
      "family": "Sherlock",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "P. J.",
      "family": "Scheuer",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2008,
        12,
        10
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_1_2_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0140-6736(00)87419-X"
    },
    {
      "key": "e_1_2_1_3_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/jcp.25.10.850"
    },
    {
      "key": "e_1_2_1_4_2",
      "first-page": "787",
      "article-title": "Light microscopic morphology of viral hepatitis",
      "volume": "65",
      "author": "Ishak K G.",
      "year": "1976",
      "journal-title": "Amer J Clin Pathol"
    },
    {
      "key": "e_1_2_1_5_2",
      "first-page": "164",
      "volume-title": "Pathology of the liver",
      "author": "Bianchi L.",
      "year": "1979"
    },
    {
      "key": "e_1_2_1_6_2",
      "doi-asserted-by": "crossref",
      "first-page": "1041",
      "DOI": "10.1001/jama.1970.03180060019004",
      "article-title": "Viral hepatitis. Clinical and tissue culture studies",
      "volume": "214",
      "author": "Boggs J D",
      "year": "1970",
      "journal-title": "JAMA"
    },
    {
      "key": "e_1_2_1_7_2",
      "first-page": "168",
      "article-title": "Acute viral hepatitis. Type A hepatitis. Its epidemiology, clinical pictures and pathologic changes of the liver",
      "volume": "14",
      "author": "Tanikawa K.",
      "year": "1979",
      "journal-title": "Gastroenterol Jpn"
    },
    {
      "key": "e_1_2_1_8_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.2957/kanzo.22.22"
    },
    {
      "key": "e_1_2_1_9_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/infdis/132.5.532"
    },
    {
      "key": "e_1_2_1_10_2",
      "first-page": "131",
      "article-title": "The pathology of viral hepatitis types A and B in chimpanzees. A comparison",
      "volume": "85",
      "author": "Dienstag J L",
      "year": "1976",
      "journal-title": "Am J Pathol"
    },
    {
      "key": "e_1_2_1_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00428432"
    },
    {
      "key": "e_1_2_1_12_2",
      "first-page": "333",
      "article-title": "Morphologial criteria in viral hepatitis",
      "author": "International Group.",
      "year": "1971",
      "journal-title": "Lancet"
    },
    {
      "key": "e_1_2_1_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/bmj.1.5083.1315"
    },
    {
      "key": "e_1_2_1_14_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.3181/00379727-135-35049"
    }
  ],
  "container-title": "Liver",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-0676.1982.tb00178.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0676.1982.tb00178.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        11,
        8
      ]
    ],
    "date-time": "2023-11-08T16:31:49Z",
    "timestamp": 1699461109000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0676.1982.tb00178.x"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1982,
        3
      ]
    ]
  },
  "references-count": 13,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1982,
          3
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1111/j.1600-0676.1982.tb00178.x"
  ],
  "URL": "http://dx.doi.org/10.1111/j.1600-0676.1982.tb00178.x",
  "relation": {},
  "ISSN": [
    "0106-9543",
    "1600-0676"
  ],
  "subject": [],
  "container-title-short": "Liver",
  "published": {
    "date-parts": [
      [
        1982,
        3
      ]
    ]
  }
}