DOI: 10.1111/j.1600-065x.2008.00737.x. Innate immunity to virus infection

10.1111/j.1600-065x.2008.00737.x

Crossref journal-article

Wiley

Immunological Reviews (311)

Abstract

Summary: The innate immune system is essential for the initial detection of invading viruses and subsequent activation of adaptive immunity. Three classes of receptors, designated retinoic acid‐inducible gene I (RIG‐I)‐like receptors (RLRs), Toll‐like receptors (TLRs), and nucleotide oligomerization domain (NOD)‐like receptors (NLRs), sense viral components, such as double‐stranded RNA (dsRNA), single‐stranded RNA, and DNA. RLRs and TLRs play essential roles in the production of type I interferons (IFNs) and proinflammatory cytokines in cell type‐specific manners. While the RLRs play essential roles in the recognition of RNA viruses in various cells, plasmacytoid dendritic cells utilize TLRs for detecting virus invasion. NLRs play a role in the production of mature interleukin‐1β to dsRNA stimulation. Activation of innate immune cells is critical for mounting adaptive immune responses. In this review, we discuss recent advances in our understanding of the mechanisms of viral RNA recognition by these different types of receptors and its relation to acquired immune responses.

Bibliography

Takeuchi, O., & Akira, S. (2008). Innate immunity to virus infection. Immunological Reviews, 227(1), 75â86. Portico.

Authors 2

Osamu Takeuchi (first)
Shizuo Akira (additional)

References 110 Referenced 1,010

Dates

Type	When
Created	16 years, 7 months ago (Dec. 24, 2008, 9:47 p.m.)
Deposited	1 year, 11 months ago (Sept. 10, 2023, 11:34 p.m.)
Indexed	11 hours, 31 minutes ago (Aug. 21, 2025, 1:36 p.m.)
Issued	16 years, 8 months ago (Dec. 19, 2008)
Published	16 years, 8 months ago (Dec. 19, 2008)
Published Online	16 years, 8 months ago (Dec. 19, 2008)
Published Print	16 years, 7 months ago (Jan. 1, 2009)

Funders 0

None

BibTeX

@article{Takeuchi_2008, title={Innate immunity to virus infection}, volume={227}, ISSN={1600-065X}, url={http://dx.doi.org/10.1111/j.1600-065x.2008.00737.x}, DOI={10.1111/j.1600-065x.2008.00737.x}, number={1}, journal={Immunological Reviews}, publisher={Wiley}, author={Takeuchi, Osamu and Akira, Shizuo}, year={2008}, month=dec, pages={75–86} }

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