DOI: 10.1111/j.1600-065x.1999.tb01359.x. Generating MHC class I ligands from viral gene products

Generating MHC class I ligands from viral gene products

10.1111/j.1600-065x.1999.tb01359.x

Crossref journal-article

Wiley

Immunological Reviews (311)

Abstract

Summary: MHC class I molecules function to present peptides comprised of eight to I 1 residues to CD8+ T lymphocytes. Here we review the efforts of our laboratory lo understand bow cells generate such peptides from viral gene products. We particularly focus on the nature of substrates acted on by cytosolic proteases, the contribution of proteasomes and nun‐proteasomal proteases lo peptide generation, the involvement of ubiquitination in peptide generation, the intracellular localization of proteasome generation of antigenic peptides, and the trimming of peptides in the endoplasmic reticulum.

Bibliography

Yewdell, J., Anton, L. C., Bacik, I., Schubert, U., Snyder, H. L., & Bennink, J. R. (1999). Generating MHC class I ligands from viral gene products. Immunological Reviews, 172(1), 97â108. Portico.

Authors 6

Jonathan Yewdell (first)
Luis C. Anton (additional)
Igor Bacik (additional)
Ulrich Schubert (additional)
Heidi Link Snyder (additional)
Jack R. Bennink (additional)

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Dates

Type	When
Created	19 years, 4 months ago (April 30, 2006, 1:58 a.m.)
Deposited	1 year, 10 months ago (Oct. 28, 2023, 6:26 p.m.)
Indexed	4 months, 3 weeks ago (April 7, 2025, 11:03 a.m.)
Issued	25 years, 8 months ago (Dec. 1, 1999)
Published	25 years, 8 months ago (Dec. 1, 1999)
Published Online	19 years, 4 months ago (April 28, 2006)
Published Print	25 years, 8 months ago (Dec. 1, 1999)

Funders 0

None

BibTeX

@article{Yewdell_1999, title={Generating MHC class I ligands from viral gene products}, volume={172}, ISSN={1600-065X}, url={http://dx.doi.org/10.1111/j.1600-065x.1999.tb01359.x}, DOI={10.1111/j.1600-065x.1999.tb01359.x}, number={1}, journal={Immunological Reviews}, publisher={Wiley}, author={Yewdell, Jonathan and Anton, Luis C. and Bacik, Igor and Schubert, Ulrich and Snyder, Heidi Link and Bennink, Jack R.}, year={1999}, month=dec, pages={97–108} }

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