Mucosal immunity and tolerance: relevance to vaccine development
10.1111/j.1600-065x.1999.tb01339.x
Crossref journal-article
Wiley
Immunological Reviews (311)
Abstract

Summary: The mucosal immune system of mammals consists of an integrated network of lymphoid cells which work in concert with innate host factors to promote host defense. Major mucosal effector immune mechanisms include secretory antibodies, largely of immunoglobulin A (IgA) isotype, cytotoxic T cells, as well as cytokines, chemokines and their receptors. Immunologic unresponsiveness (tolerance) is a key feature of the mucosal immune system, and deliberate vaccination or natural immunization by a mucosal route can effectively induce immune suppression. The diverse compartments located in the aerodigestive and genitourinary tracts and exocrine glands communicate via preferential homing of lymphocytes and antigen‐presenting cells. Mucosal administration of antigens may result in the concomitant expression of secretory immunoglobulin A (S‐IgA) antibody responses in various mucosal tissues and secretions, and under certain conditions, in the suppression of immune responses. Thus, developing formulations based on efficient delivery of selected anti‐gens/tolerogens, cytokines and adjuvants may impact on the design of future vaccines and of specific immunotherapeutic approaches against diseases associated with untoward immune responses, such as autoimmune disorders, allergic reactions, and tissue‐damaging inflammatory reactions triggered by persistent microorganisms.

Bibliography

Czerkinsky, C., Anjueie, F., McGhee, J. R., Geoige‐Chundy, A., Holmgren, J., Kieny, M., Fujiyashi, K., Mestecky, J. F., Pierrefite‐Carle, V., Rusk, C., & Sun, J. (1999). Mucosal immunity and tolerance: relevance to vaccine development. Immunological Reviews, 170(1), 197–222. Portico.

Authors 11
  1. Cecil Czerkinsky (first)
  2. Fabienne Anjueie (additional)
  3. Jerry R. McGhee (additional)
  4. Annie Geoige‐Chundy (additional)
  5. Jon Holmgren (additional)
  6. Marie‐Paule Kieny (additional)
  7. Kohlaro Fujiyashi (additional)
  8. Jiri F. Mestecky (additional)
  9. Valérie Pierrefite‐Carle (additional)
  10. Carok Rusk (additional)
  11. Jia‐Bin Sun (additional)
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Dates
Type When
Created 19 years, 4 months ago (April 30, 2006, 1:32 a.m.)
Deposited 1 year, 10 months ago (Oct. 28, 2023, 8:41 a.m.)
Indexed 1 day, 5 hours ago (Sept. 4, 2025, 10:01 a.m.)
Issued 26 years, 1 month ago (Aug. 1, 1999)
Published 26 years, 1 month ago (Aug. 1, 1999)
Published Online 19 years, 4 months ago (April 28, 2006)
Published Print 26 years, 1 month ago (Aug. 1, 1999)
Funders 0

None

@article{Czerkinsky_1999, title={Mucosal immunity and tolerance: relevance to vaccine development}, volume={170}, ISSN={1600-065X}, url={http://dx.doi.org/10.1111/j.1600-065x.1999.tb01339.x}, DOI={10.1111/j.1600-065x.1999.tb01339.x}, number={1}, journal={Immunological Reviews}, publisher={Wiley}, author={Czerkinsky, Cecil and Anjueie, Fabienne and McGhee, Jerry R. and Geoige‐Chundy, Annie and Holmgren, Jon and Kieny, Marie‐Paule and Fujiyashi, Kohlaro and Mestecky, Jiri F. and Pierrefite‐Carle, Valérie and Rusk, Carok and Sun, Jia‐Bin}, year={1999}, month=aug, pages={197–222} }