DOI: 10.1111/j.1600-065x.1998.tb01229.x. Natural killer cell differentiation: insights from knockout and transgenic mouse models and in vitro systems

Natural killer cell differentiation: insights from knockout and transgenic mouse models and in vitro systems

10.1111/j.1600-065x.1998.tb01229.x

Crossref journal-article

Wiley

Immunological Reviews (311)

Abstract

Summary: In the last few years, the routine development of knockout and transgenic mice and the ease with which rare progenitor populations can be isolated from hematopoietic organs and cultured in vitro has facilitated significant advances in understanding the lineage and development of natural killer (NK) cells. Fluorescence‐activated cell sorter analyses have identified a common lymphoid progenitor capable of giving rise to NK, T, and B cells, confirming the lymphoid origin of NK cells. Knockout and transgenic mouse models have pointed to an absolutely critical role for signals sent through the interleukin (IL)‐2/lS receptor β (CD 122) chain and common γ (γc) chain for NK development. Such signals are likely relayed inside the cell by the tyrosine kinase Jak3, which associates with γc. Recently developed IL‐15 and IL‐15 receptor a knockout mice have pinpointed IL‐15 as the mediator of this signal. Other mouse models have indicated an unexpected role for flt3 ligand in early NK‐cell development as well as minor roles for stem cell factor and IL‐7 in expanding NK‐cell progenitor numbers. Finally, in vitro culture systems have proven useful in identifying the point in NK development at which each of these signals is critical.

Bibliography

Williams, N. S., Klem, J., Puzanov, I. J., Sivakumar, P. V., Schatzle, J. D., Bennett, M., & Kumar, V. (1998). Natural killer cell differentiation: insights from knockout and transgenic mouse models and in vitro systems. Immunological Reviews, 165(1), 47â61. Portico.

Authors 7

Noelle Sevilir Williams (first)
Jennifer Klem (additional)
Igor J. Puzanov (additional)
P. V. Sivakumar (additional)
John D. Schatzle (additional)
Michael Bennett (additional)
Vinay Kumar (additional)

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Dates

Type	When
Created	19 years, 4 months ago (April 30, 2006, 12:56 a.m.)
Deposited	1 year, 10 months ago (Oct. 28, 2023, 2:56 a.m.)
Indexed	1 week, 6 days ago (Aug. 23, 2025, 1:02 a.m.)
Issued	26 years, 11 months ago (Oct. 1, 1998)
Published	26 years, 11 months ago (Oct. 1, 1998)
Published Online	19 years, 4 months ago (April 28, 2006)
Published Print	26 years, 11 months ago (Oct. 1, 1998)

Funders 0

None

BibTeX

@article{Williams_1998, title={Natural killer cell differentiation: insights from knockout and transgenic mouse models and in vitro systems}, volume={165}, ISSN={1600-065X}, url={http://dx.doi.org/10.1111/j.1600-065x.1998.tb01229.x}, DOI={10.1111/j.1600-065x.1998.tb01229.x}, number={1}, journal={Immunological Reviews}, publisher={Wiley}, author={Williams, Noelle Sevilir and Klem, Jennifer and Puzanov, Igor J. and Sivakumar, P. V. and Schatzle, John D. and Bennett, Michael and Kumar, Vinay}, year={1998}, month=oct, pages={47–61} }

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  "abstract": "<jats:p><jats:bold>Summary: </jats:bold> In the last few years, the routine development of knockout and transgenic mice and the ease with which rare progenitor populations can be isolated from hematopoietic organs and cultured in vitro has facilitated significant advances in understanding the lineage and development of natural killer (NK) cells. Fluorescence\u2010activated cell sorter analyses have identified a common lymphoid progenitor capable of giving rise to NK, T, and B cells, confirming the lymphoid origin of NK cells. Knockout and transgenic mouse models have pointed to an absolutely critical role for signals sent through the interleukin (IL)\u20102/lS receptor \u03b2 (CD 122) chain and common \u03b3 (\u03b3c) chain for NK development. Such signals are likely relayed inside the cell by the tyrosine kinase Jak3, which associates with \u03b3c. Recently developed IL\u201015 and IL\u201015 receptor a knockout mice have pinpointed IL\u201015 as the mediator of this signal. Other mouse models have indicated an unexpected role for flt3 ligand in early NK\u2010cell development as well as minor roles for stem cell factor and IL\u20107 in expanding NK\u2010cell progenitor numbers. Finally, in vitro culture systems have proven useful in identifying the point in NK development at which each of these signals is critical.</jats:p>",
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