DOI: 10.1111/j.1600-065x.1997.tb00943.x. Major histocompatibility complex class I‐specific receptors on human natural killer and T lymphocytes

Major histocompatibility complex class I‐specific receptors on human natural killer and T lymphocytes

10.1111/j.1600-065x.1997.tb00943.x

Crossref journal-article

Wiley

Immunological Reviews (311)

Abstract

Summary: Human NK cells express several specialized inhibitory receptors that recognize major histocompatibility complex (MHC) class I molecules expressed on normal cells. The lack of expression of one or more HLA CLASS I alleles leads to NK‐mediated target cell lysis. Receptors specific for groups of HLA‐C (p58), HLA‐B (p70) and HLA‐A (p140) alleles belong to the Ig superfamily with two or three Ig‐like domains in their extracellular portion, and a long cytoplasmic tail containing ITIM motifs and associated with a non‐polar transmembrane portion. In contrast, the CD94/NKG2‐A receptor complex is composed of type II proteins with a C‐type lectin domain which displays a more broad specificity for different class I alleles. Recently, activatory forms of the HLA‐C‐specific receptors have been identified in some donors. They are virtually identical to the inhibitory forms in their extracellular portions, but display a short cytoplasmic tail lacking ITIM motifs associated with a Lys‐containing transmembrane portion (p50). A subset of activated T‐lymphocytes. primarily CD8+ and oligoclonal or monoclonal in nature, express NK‐type class I‐specific receptors. These receptors exert an inhibitory activity on T‐cell receptor‐mediated functions and may provide an important mechanism of down‐regulation of T‐cell responses.

Bibliography

Moretta, A., Biassoni, R., Bottino, C., Pende, D., Vitale, M., Poggi, A., Mingari, M. C., & Moretta, L. (1997). Major histocompatibility complex class Iâspecific receptors on human natural killer and T lymphocytes. Immunological Reviews, 155(1), 105â117. Portico.

Authors 8

Alessandro Moretta (first)
Roberto Biassoni (additional)
Cristina Bottino (additional)
Daniela Pende (additional)
Massimo Vitale (additional)
Alessandro Poggi (additional)
Maria Cristina Mingari (additional)
Lorenzo Moretta (additional)

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Dates

Type	When
Created	19 years, 3 months ago (April 29, 2006, 7:50 p.m.)
Deposited	1 year, 10 months ago (Oct. 27, 2023, 11:25 a.m.)
Indexed	2 months, 3 weeks ago (June 6, 2025, 9:05 a.m.)
Issued	28 years, 6 months ago (Feb. 1, 1997)
Published	28 years, 6 months ago (Feb. 1, 1997)
Published Online	19 years, 4 months ago (April 28, 2006)
Published Print	28 years, 6 months ago (Feb. 1, 1997)

Funders 0

None

BibTeX

@article{Moretta_1997, title={Major histocompatibility complex class I‐specific receptors on human natural killer and T lymphocytes}, volume={155}, ISSN={1600-065X}, url={http://dx.doi.org/10.1111/j.1600-065x.1997.tb00943.x}, DOI={10.1111/j.1600-065x.1997.tb00943.x}, number={1}, journal={Immunological Reviews}, publisher={Wiley}, author={Moretta, Alessandro and Biassoni, Roberto and Bottino, Cristina and Pende, Daniela and Vitale, Massimo and Poggi, Alessandro and Mingari, Maria Cristina and Moretta, Lorenzo}, year={1997}, month=feb, pages={105–117} }

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