DOI: 10.1111/j.1600-0625.1995.tb00250.x. Mast cell ontogeny and apoptosis

10.1111/j.1600-0625.1995.tb00250.x

Crossref journal-article

Wiley

Experimental Dermatology (311)

Abstract

Abstract The regulation of tissue mast cell number depends both on the rate of production of mast cell precursors from bone marrow and the length of survival of mature mast cells within tissues. Mast cells develop from bone marrow under the influence of both interleukin‐3 (IL‐3) and the c‐kit ligand, also known as stem cell factor (SCF). In humans, the mast cell precursor is CD34+, FcERI‐. Mast cell precursors with time become less responsive to IL‐3 and more responsive to SCF. Mast cell proliferation directed by SCF is enhanced by other cytokines including both IL‐4 and IL‐10. Once mast cell precursors target to tissues, their survival may largely be dependent upon the local production of SCF. Withdrawal of IL‐3 or SCF results in mast cell apoptosis; SCF rescues mast cells following IL‐3 withdrawal. TGF‐beta prevents this SCF rescue. Engagement of extracellular matrix by integrin receptors may also effect mast cell numbers. Thus, in the final analysis, mast cell numbers, while relatively constant in the normal state, may be up‐regulated by altering the rate of their production centrally or length of survival in the periphery.

Bibliography

Metcalfe, D. D., Mekori, J. A., & Rottem, M. (1995). Mast cell ontogeny and apoptosis. Experimental Dermatology, 4(4), 227â230. Portico.

Authors 3

Dean D. Metcalfe (first)
Joseph A. Mekori (additional)
Menachem Rottem (additional)

References 34 Referenced 31

10.1016/0002-9343(91)90214-I
10.1016/0091-6749(88)90015-2
10.1182/blood.V52.2.447.447
10.1182/blood.V53.3.492.492 / Blood / Decreased production of mast cells in SI/SId anemic mice by Kitamura Y (1979)
10.1038/335088a0
10.1016/0092-8674(90)90304-W
10.1016/0092-8674(90)90303-V
10.1016/0092-8674(90)90301-T
10.1002/jcp.1041120120
10.4049/jimmunol.126.2.452 / J Immunol / The in vitro production and cloning of the P cell, a bone marrow‐derived null cell that expresses H‐2 and la‐antigens, has mast cell‐like granules, and is regulated by a factor released by activated T cells by Schrader J W (1981)
10.4049/jimmunol.131.1.282 / J Immunol / Biological properties of homogeneous intcrleukin 3 (I). Demonstration of WEHI‐3 growth‐factor activity, mast cell growth‐factor activity, P cell‐stimulating factor activity and histamine‐producing factor activity by Ihle J H (1983)
10.1084/jem.173.2.507
{'key': 'e_1_2_1_14_2', 'first-page': '147', 'volume-title': 'Contemp topics in molecular immunology', 'author': 'Tyung Y P', 'year': '1984'} / Contemp topics in molecular immunology by Tyung Y P (1984)
10.4049/jimmunol.143.1.135 / J Immunol / Inhibition of the growth of IL‐3‐dependent mast cells from murine bone marrow by recombinant granulocyte macrophage‐colony stimulating factor by Bressler R B (1989)
{'key': 'e_1_2_1_16_2', 'first-page': '591', 'article-title': 'Transforming growth factor‐beta 1 selectively inhibits IL‐3‐dependent mast cell proliferation with out affecting mast cell function or differentiation', 'volume': '143', 'author': 'Brodie D H', 'year': '1989', 'journal-title': 'J Immunol'} / J Immunol / Transforming growth factor‐beta 1 selectively inhibits IL‐3‐dependent mast cell proliferation with out affecting mast cell function or differentiation by Brodie D H (1989)
10.1073/pnas.83.7.2061
10.1002/eji.1830200632 / Eur J Immunol / Mast cell enhance ment activity is structurally related and functionally identical to the novel mouse T cell growth factor P40/TCGFIU by Hultner L (1990)
10.1073/pnas.88.14.6382
10.4049/jimmunol.151.9.4950 / J Immunol / The effects of stem cell factor (SCF) on the ultrastruclure of FcERI+ cells developing in IL‐3‐dependenl bone marrow‐derived cultures by Rottem M (1993)
10.1172/JCI114557
10.1182/blood.V79.4.972.bloodjournal794972 / Blood / Kinetics of the appearance of FcERI‐bearing cells in interleukin 3‐dependenl mouse bone marrow cultures: correlation with histamine content and mast cell maturation by Rottem M (1992)
RottemM HullG MetcalfeD D.Demonstration of differential effects of cytokines on the derivation of mast cells from murine bone marrow and peripheral blood mononuclear cells. Exp Hemalol in press.
10.4049/jimmunol.145.10.3425 / J Immunol / Regulation of mast cell adhesion to laminin by Thompson H L (1990)
10.4049/jimmunol.142.7.2424 / J Immunol / Interleukin 3‐dependent growth of basophil‐like and mast cell‐like cells from human marrow by Kirshenbaum A S (1989)
10.4049/jimmunol.148.3.772
10.4049/jimmunol.146.5.1410
{'key': 'e_1_2_1_28_2', 'article-title': 'Mast cells cultured from the peripheral blood of normal donors and patients with mastocytosis originate from a CD34+/FcERI‐ cell population', 'author': 'Rottem M', 'year': '1995', 'journal-title': 'Blood'} / Blood / Mast cells cultured from the peripheral blood of normal donors and patients with mastocytosis originate from a CD34+/FcERI‐ cell population by Rottem M (1995)
KirshenbaumA S GoffJ P AlbertS KesslerW MetcalfeD D.Fibroblasts determine the fate of FcERI+ cell populations in vitro by selectively supporting the viability of mast cells while internalizing and degrading basophils. Int Arch Allergy Appl Immunol1995: in press. (10.1159/000236786)
10.4049/jimmunol.149.11.3665 / J Immunol / IL‐3‐dependent mast cells attach to plate‐bound vitronectin: Demon stration of augmented proliferation in response to signals transduced via cell surface vitronectin receptors by Bianchine P J (1992)
10.4049/jimmunol.152.1.213 / J Immunol / Stem cell factor induces mast cells adhesion to fibronectin by Dastych J (1994)
10.4049/jimmunol.151.7.3775 / J Immunol / IL‐3 dependent mast cells undergo apoptosis on removal of IL‐3. Prevention of apoptosis bye‐kit ligand by Mekori Y A (1993)
{'key': 'e_1_2_1_33_2', 'first-page': '2194', 'article-title': 'The c‐kit ligand, stem cell factor, promotes mast cell survival by suppressing apoplosis', 'volume': '153', 'author': 'Inemura A', 'year': '1994', 'journal-title': 'Am J Pathol'} / Am J Pathol / The c‐kit ligand, stem cell factor, promotes mast cell survival by suppressing apoplosis by Inemura A (1994)
10.4049/jimmunol.153.5.2194 / J Immunol / Transforming growth factorbeta prevents stem cell factor‐mediated rescue of mast cells from apoptosis after IL‐3 deprivation by Mekori Y A (1994)
10.1182/blood.V83.11.3138.3138 / Blood / TGF‐beta regulates c‐kit message stability and cell‐surface protein expression in hemopoielic progenitors by Dubois C M (1994)

Dates

Type	When
Created	19 years, 4 months ago (April 11, 2006, 1:38 p.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 4:35 p.m.)
Indexed	3 months, 1 week ago (May 18, 2025, 12:03 p.m.)
Issued	30 years ago (Aug. 1, 1995)
Published	30 years ago (Aug. 1, 1995)
Published Online	19 years, 4 months ago (April 11, 2006)
Published Print	30 years ago (Aug. 1, 1995)

Funders 0

None

BibTeX

@article{Metcalfe_1995, title={Mast cell ontogeny and apoptosis}, volume={4}, ISSN={1600-0625}, url={http://dx.doi.org/10.1111/j.1600-0625.1995.tb00250.x}, DOI={10.1111/j.1600-0625.1995.tb00250.x}, number={4}, journal={Experimental Dermatology}, publisher={Wiley}, author={Metcalfe, Dean D. and Mekori, Joseph A. and Rottem, Menachem}, year={1995}, month=aug, pages={227–230} }

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