DOI: 10.1111/j.1600-0447.1992.tb03279.x. D<sub>2</sub> dopamine receptor genotype and cerebrospinal fluid homovanillic acid, 5‐hydroxyindoleacetic acid and 3‐methoxy‐4‐hydroxyphenylglycol in alcoholics in Finland and the United States

D2 dopamine receptor genotype and cerebrospinal fluid homovanillic acid, 5‐hydroxyindoleacetic acid and 3‐methoxy‐4‐hydroxyphenylglycol in alcoholics in Finland and the United States

10.1111/j.1600-0447.1992.tb03279.x

Crossref journal-article

Wiley

Acta Psychiatrica Scandinavica (311)

Abstract

If a genetic association between the D2 dopamine receptor genotype and alcoholism is mediated by altered dopamine function, then a stronger association might be found in alcoholics who are deviant in indices of dopamine function and by comparing alcoholics to nonalcoholics matched for ethnic origin. Therefore, we evaluated the D2/TaqI polymorphism in 29 impulsive violent alcoholic Finns, 17 nonimpulsive violent alcoholic Finns and 36 Finnish controls free of mental disorders, alcoholism and substance abuse. In 37 of the alcoholics, we measured cerebrospinal fluid (CSF) homovanillic acid (HVA), 5‐hydroxyindoleacetic acid (5‐HIAA) and 3‐methoxy‐4‐hydroxyphenylglycol. There was no relationship between D2/Taq 1 genotype and concentrations of these monoamine metabolites in this group, which exhibits lower CSF HVA and 5‐HIAA as compared to controls. There was also no genotypic difference between Finnish alcoholics and nonalcoholic controls. The lack of relationship between D2/Taq1 genotype and HVA concentration was replicated in 24 Caucasian alcoholics in the United States.

Bibliography

Goldman, D., Dean, M., Brown, G. L., Bolos, A. M., Tokola, R., Virkkunen, M., & Linnoila, M. (1992). D2 dopamine receptor genotype and cerebrospinal fluid homovanillic acid, 5âhydroxyindoleacetic acid and 3âmethoxyâ4âhydroxyphenylglycol in alcoholics in Finland and the United States. Acta Psychiatrica Scandinavica, 86(5), 351â357. Portico.

Authors 7

D. Goldman (first)
M. Dean (additional)
G. L. Brown (additional)
A. M. Bolos (additional)
R. Tokola (additional)
M. Virkkunen (additional)
M. Linnoila (additional)

References 39 Referenced 89

10.1001/jama.1990.03440150063027
10.1001/archpsyc.1991.01810310073013
10.1016/0741-8329(91)90693-Q
10.1001/jama.1991.03470130073032 / JAMA / The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders by Comings DE. (1991)
10.1001/jama.1991.03470130113040 / JAMA / D2 dopamine receptor gene is associated but not linked to alcoholism by Cloninger CR. (1991)
10.1001/archpsyc.1992.01820020068010
10.1001/jama.1990.03450240058040 / JAMA / Population and pedigree studies reveal a lack of association between the dopamine D2 receptor gene and alcoholism by Bolos AM. (1991)
10.1001/jama.1991.03470130081033 / JAMA / No association between an allele at the D2 dopamine receptor gene (DRD2) and alcoholism by Gelernter J. (1991)
10.1016/0006-3223(92)90052-2
{'key': 'e_1_2_1_11_2', 'first-page': '203', 'article-title': 'Allelic association of human dopamine D2‐receptor DNA polymorphism ruled out in 45 alcoholics', 'volume': '49', 'author': 'Schwab S.', 'year': '1991', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / Allelic association of human dopamine D2‐receptor DNA polymorphism ruled out in 45 alcoholics by Schwab S. (1991)
10.1176/ajp.127.12.1653
10.1001/jama.1991.03460200047018
10.1016/0888-7543(91)90096-W
10.1001/archpsyc.1991.01810290049010
10.1111/j.1440-1819.1974.tb02312.x
{'key': 'e_1_2_1_17_2', 'first-page': '635', 'article-title': 'Cerebrospinal fluid homovanillic acid in male alcoholics: effects of disulfiram', 'volume': '12', 'author': 'Major LF.', 'year': '1977', 'journal-title': 'Biol Psychiatry'} / Biol Psychiatry / Cerebrospinal fluid homovanillic acid in male alcoholics: effects of disulfiram by Major LF. (1977)
10.1001/archpsyc.1989.01810070030004
10.1001/archpsyc.1991.01810310082014
{'key': 'e_1_2_1_20_2', 'article-title': 'D2 dopamine receptor genotype, linkage disequilibrium and alcoholism in American Indian and Caucasian alcoholics', 'author': 'Goldman D.', 'journal-title': 'Alcohol Clin Exp Res'} / Alcohol Clin Exp Res / D2 dopamine receptor genotype, linkage disequilibrium and alcoholism in American Indian and Caucasian alcoholics by Goldman D.
10.1001/archpsyc.1989.01810070039006
{'key': 'e_1_2_1_22_2', 'first-page': '778', 'article-title': 'The human dopamine D2 receptor gene is located on chromosome 11 at q22q23 and identifies a Taq I RFLP', 'volume': '45', 'author': 'Grandy DK.', 'year': '1989', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / The human dopamine D2 receptor gene is located on chromosome 11 at q22q23 and identifies a Taq I RFLP by Grandy DK. (1989)
10.1016/0024-3205(83)90344-2
10.1016/0003-2697(83)90162-8
10.1016/0165-1781(79)90053-2
10.1016/0024-3205(85)90242-5
10.1111/j.1600-0447.1984.tb06860.x
10.1016/0006-8993(91)90489-I
{'key': 'e_1_2_1_29_2', 'first-page': '60', 'article-title': 'The pharmacology of ethanol self‐administration in Wistar and alcohol preferring rats', 'volume': '15', 'author': 'Koob GF.', 'year': '1989', 'journal-title': 'Soc Neurosci Abstr'} / Soc Neurosci Abstr / The pharmacology of ethanol self‐administration in Wistar and alcohol preferring rats by Koob GF. (1989)
10.1016/0741-8329(90)90008-Z
10.1001/archpsyc.1991.01810310066012
10.1111/j.2042-7158.1967.tb09604.x
10.1016/0304-3940(83)90300-2
10.1007/BF00426825
10.1016/0024-3205(80)90108-3
{'key': 'e_1_2_1_36_2', 'first-page': '219', 'article-title': 'Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol', 'volume': '239', 'author': 'Imperato A.', 'year': '1986', 'journal-title': 'J Pharmacol Exp Ther'} / J Pharmacol Exp Ther / Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol by Imperato A. (1986)
10.1126/science.3854
10.1007/978-1-4615-7718-8_19
10.1002/gepi.1370040602
{'key': 'e_1_2_1_40_2', 'first-page': '879', 'article-title': 'Segregation analysis of alcoholism in families ascertained through a pair of male alcoholics', 'volume': '46', 'author': 'Aston CE.', 'year': '1990', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / Segregation analysis of alcoholism in families ascertained through a pair of male alcoholics by Aston CE. (1990)

Dates

Type	When
Created	18 years ago (Aug. 23, 2007, 8:35 a.m.)
Deposited	1 year, 10 months ago (Oct. 23, 2023, 8:09 a.m.)
Indexed	3 days, 11 hours ago (Sept. 4, 2025, 9:49 a.m.)
Issued	32 years, 10 months ago (Nov. 1, 1992)
Published	32 years, 10 months ago (Nov. 1, 1992)
Published Online	18 years ago (Aug. 23, 2007)
Published Print	32 years, 10 months ago (Nov. 1, 1992)

Funders 0

None

BibTeX

@article{Goldman_1992, title={D2 dopamine receptor genotype and cerebrospinal fluid homovanillic acid, 5‐hydroxyindoleacetic acid and 3‐methoxy‐4‐hydroxyphenylglycol in alcoholics in Finland and the United States}, volume={86}, ISSN={1600-0447}, url={http://dx.doi.org/10.1111/j.1600-0447.1992.tb03279.x}, DOI={10.1111/j.1600-0447.1992.tb03279.x}, number={5}, journal={Acta Psychiatrica Scandinavica}, publisher={Wiley}, author={Goldman, D. and Dean, M. and Brown, G. L. and Bolos, A. M. and Tokola, R. and Virkkunen, M. and Linnoila, M.}, year={1992}, month=nov, pages={351–357} }

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