DOI: 10.1111/j.1538-7836.2007.02446.x. The intrinsic pathway of coagulation: a target for treating thromboembolic disease?

The intrinsic pathway of coagulation: a target for treating thromboembolic disease?

10.1111/j.1538-7836.2007.02446.x

Crossref journal-article

Elsevier BV

Journal of Thrombosis and Haemostasis (78)

Bibliography

GAILANI, D., & RENNÃ, T. (2007). The intrinsic pathway of coagulation: a target for treating thromboembolic disease? Journal of Thrombosis and Haemostasis, 5(6), 1106â1112.

Authors 2

D. GAILANI (first)
T. RENNÉ (additional)

References 67 Referenced 163

10.1182/blood.V70.1.1.1 / Blood / The coagulation‐kinin pathway of human plasma by Kaplan (1987)
10.1016/S0065-2776(08)60837-8 / Adv Immunol / The biochemistry and pathophysiology of the contact system of plasma by Cochrane (1982)
10.1016/S0065-2776(08)60599-4 / Adv Immunol / The intrinsic coagulation/kinin‐forming cascade: assembly in plasma and cell surfaces in inflammation by Kaplan (1997)
10.1182/blood.V90.10.3819 / Blood / Contact system: a vascular biology modulator with anticoagulant, profibrinolytic, antiadhesive, and proinflammatory attributes by Colman (1997)
10.1038/202498a0 / Nature / An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier by Macfarlane (1964)
10.1126/science.145.3638.1310 / Science / Waterfall sequence for intrinsic clotting by Davie (1964)
10.1021/bi00107a001 / Biochemistry / The coagulation cascade: initiation, maintenance and regulation by Davie (1991)
{'key': '10.1111/j.1538-7836.2007.02446.x_bb0045', 'series-title': 'Hematology: Basic Principles and Practice', 'first-page': '2001', 'article-title': 'Laboratory evaluation of hemostatic disorders', 'author': 'Rand', 'year': '2005'} / Hematology: Basic Principles and Practice / Laboratory evaluation of hemostatic disorders by Rand (2005)
10.1074/jbc.M105221200 / J Biol Chem / Characterization of the H‐kininogen‐binding site on factor XI: a comparison of factor XI and plasma prekallikrein by Renne (2002)
{'key': '10.1111/j.1538-7836.2007.02446.x_bb0055', 'series-title': 'Hematology: Basic Principles and Practice', 'first-page': '2047', 'article-title': 'Clinical aspects and therapy of hemophilia', 'author': 'Lozier', 'year': '2005'} / Hematology: Basic Principles and Practice / Clinical aspects and therapy of hemophilia by Lozier (2005)
10.1056/NEJM199107183250303 / N Eng J Med / Factor XI deficiency in Ashkenazi Jews in Israel by Asakai (1991)
{'key': '10.1111/j.1538-7836.2007.02446.x_bb0065', 'series-title': 'The Metabolic and Molecular Bases of Inherited Disease', 'first-page': '4433', 'article-title': 'Factor XI and the contact system', 'author': 'Gailani', 'year': '2001'} / The Metabolic and Molecular Bases of Inherited Disease / Factor XI and the contact system by Gailani (2001)
10.1182/blood.V90.10.3962 / Blood / A coagulation factor IX‐deficient mouse model for human hemophilia B by Lin (1997)
10.1097/00001721-199703000-00008 / Blood Coag Fibrinol / A murine model of factor XI deficiency by Gailani (1997)
10.1160/TH04-04-0250 / Thromb Haemost / Targeted deletion of murine coagulation factor XII gene‐a model for contact phase activation in vivo by Pauer (2004)
10.1073/pnas.0932632100 / Proc Nat Acad Sci USA / The evolution of vertebrate coagulation as viewed from a comparison of puffer fish and sea squirt genomes by Jiang (2003)
10.1016/S0049-3848(97)00307-1 / Thromb Res / Whale Hageman factor (factor XII): prevented production due to pseudogene conversion by Semba (1998)
10.1021/bi00485a001 / Biochem / Regulation of coagulation by a multivalent Kunitz‐type inhibitor by Broze (1990)
10.1074/jbc.M312827200 / J Biol Chem / Formation of factor IXa and Xa by the extrinsic pathway: differential regulation by tissue factor pathway inhibitor and antithrombin by Lu (2004)
10.1182/blood-2003-12-4352 / Blood / Platelet deposition inhibits tissue factor activity: in vitro clots are impermeable to factor Xa by Hathcock (2004)
10.1182/blood-2004-03-0935 / Blood / Hematopoietic cell‐derived microparticle tissue factor contributes to fibrin formation during thrombus propagation by Chou (2004)
10.1182/blood-2004-06-2225 / Blood / Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall by Day (2005)
10.1021/bi972113+ / Biochem / Prothrombin is a cofactor for binding of factor XI to the platelet surface and for platelet‐mediated factor XI activation by thrombin by Baglia (1998)
10.1074/jbc.M000464200 / J Biol Chem / Thrombin‐mediated feedback activation of factor XI on the activated platelet surface is preferred over contact activation by factor XIIa or factor XIa by Baglia (2000)
10.1126/science.1652157 / Science / Factor XI activation in a revised model of blood coagulation by Gailani (1991)
10.1182/blood.V86.8.3035.3035 / Blood / Feedback activation of factor XI by thrombin in plasma results in additional formation of thrombin that protects fibrin clots from fibrinolysis by Von Dem Borne (1995)
10.1074/jbc.270.24.14477 / J Biol Chem / Purification and characterization of thrombin activatable fibrinolysis inhibitor (TAFI), a thrombin‐activatable fibrinolysis inhibitor by Bajzar (1995)
10.1172/JCI119412 / J Clin Invest / Thrombin‐mediated activation of factor XI results in a thrombin‐activatable fibrinolysis inhibitor‐dependent inhibition of fibrinolysis by Von dem Borne (1997)
10.1055/s-0037-1615964 / Thromb Haemost / The role of factor XI in thrombin generation induced by low concentrations of tissue factor by Keularts (2001)
10.1182/blood.V91.12.4581 / Blood / Blood coagulation in hemophilia A and hemophilia C by Cawthern (1998)
10.1073/pnas.0507195103 / Proc Natl Acad Sci USA / Polyphosphate modulates blood coagulation and fibrinolysis by Smith (2006)
10.1084/jem.20050664 / J Exp Med / Defective thrombus formation in mice lacking coagulation factor XII by Renne (2005)
{'key': '10.1111/j.1538-7836.2007.02446.x_bb0170', 'first-page': '347', 'article-title': 'Activation of blood clotting factors by microbial proteinases', 'volume': '121', 'author': 'Kaminishi', 'year': '1994', 'journal-title': 'FEBS Microbiol Lett'} / FEBS Microbiol Lett / Activation of blood clotting factors by microbial proteinases by Kaminishi (1994)
10.1084/jem.192.10.1415 / J Exp Med / Severe lung lesions caused by Salmonella are prevented by inhibition of the contact system by Persson (2000)
10.1016/S0021-9258(19)50297-6 / J Biol Chem / Human Hageman factor (factor XII) and high molecular weight kininogen compete for the same binding site on human umbilical vein endothelial cells by Reddigari (1987)
10.4049/jimmunol.175.5.3377 / J Immunol / Local bradykinin formation is controlled by glycosaminoglycans by Renne (2005)
10.1055/s-0037-1615837 / Thromb Haemost / Activation of the plasma/kallikrein system on cells: a revised hypothesis by Schmaier (1999)
10.1073/pnas.022626899 / Proc Natl Acad Sci USA / Heat shock protein 90 catalyzes activation of the prekallikrein‐kininogen complex in the absence of factor XII by Joseph (2002)
10.1182/blood-2003-07-2510 / Blood / Recombinant prolylcarboxypeptidase activates plasma prekallikrein by Shariat‐Madar (2004)
10.1074/jbc.273.50.33224 / J Biol Chem / A novel mechanism for bradykinin production at inflammatory sites. Diverse effects of a mixture of neutrophil elastase and mast cell tryptase versus tissue and plasma kallikreins on native and oxidized kininogens by Kozik (1998)
10.1111/j.1538-7836.2005.01236.x / J Thromb Haemost / Effects of factor IX or factor XI deficiency on ferric chloride‐induced carotid artery occlusion in mice by Wang (2005)
10.1172/JCI0212119 / J Clin Invest / Thrombin‐activatable fibrinolysis inhibitor (TAFI) deficiency is compatible with murine life by Nagashima (2002)
10.1172/JCI26987 / J Clin Invest / Thrombus formation in vivo by Furie (2005)
{'key': '10.1111/j.1538-7836.2007.02446.x_bb0225', 'first-page': '66a', 'article-title': 'Factor XI deficient mice have reduced platelet accumulation and fibrin deposition after laser injury', 'volume': '104', 'author': 'Baird', 'year': '2004', 'journal-title': 'Blood'} / Blood / Factor XI deficient mice have reduced platelet accumulation and fibrin deposition after laser injury by Baird (2004)
10.1055/s-0037-1613081 / Thromb Haemost / FXI is essential for thrombus formation following FeCl3‐induced injury of the carotid artery in the mouse by Rosen (2002)
10.1084/jem.20052458 / J Exp Med / Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis by Kleinschnitz (2006)
10.1084/jem.190.1.91 / J Exp Med / Targeted inhibition of intrinsic coagulation limits cerebral injury in stroke without increasing intracerebral hemorrhage by Choudhri (1999)
10.1055/s-0037-1613209 / Thromb Haemost / Platelet activation and blood coagulation by Heemskerk (2002)
10.1182/blood.V57.1.106.106 / Blood / Contributions of human platelets to the proteolytic activation of blood coagulation factors XII and XI by Walsh (1981)
10.1515/BC.2006.023 / Biol Chem / Platelets promote coagulation factor XII‐mediated proteolytic cascade systems in plasma by Johne (2006)
10.1056/NEJM200003093421004 / N Engl J Med / High levels of coagulation factor XI as a risk factor for venous thrombosis by Meijers (2000)
10.1182/blood-2005-12-023697 / Blood / Levels of intrinsic coagulation factors and the risk of myocardial infarction among men. Opposite and synergistic effects of factors XI and XII by Doggen (2006)
10.1046/j.1538-7836.2003.00195.x / J Thromb Haemost / Inherited factor XI deficiency confers no protection against acute myocardial infarction by Salomon (2003)
10.1309/QC259F09UNMKVP0R / Am J Clin Pathol / Elevated factor XI activity levels are associated with an increased odds ratio for cerebrovascular events by Yang (2006)
10.1172/JCI781 / J Clin Invest / Enhancement of rabbit jugular vein thrombolysis by neutralization of factor XI. In vivo evidence for a role of factor XI as an anti‐fibrinolytic factor by Minnema (1998)
10.1111/j.1538-7836.2006.01973.x / J Thromb Haemost / Factor XI contributes to thrombus propagation on injured neointima of the rabbit iliac artery by Yamashita (2006)
10.1182/blood-2003-01-0324 / Blood / Factor XI‐dependence of surface‐ and tissue factor‐initiated thrombus formation in primates by Gruber (2003)
{'key': '10.1111/j.1538-7836.2007.02446.x_bb0295', 'first-page': '151', 'article-title': 'The George M. Kober lecture. The legacy of John Hageman: new dividends', 'volume': '98', 'author': 'Ratnoff', 'year': '1985', 'journal-title': 'Trans Assoc Am Physicians'} / Trans Assoc Am Physicians / The George M. Kober lecture. The legacy of John Hageman: new dividends by Ratnoff (1985)
10.1111/j.1365-2141.1994.tb04937.x / Br J Haematol / John Hageman’s factor and deep‐vein thrombosis: Leiden thrombophilia Study by Koster (1994)
10.1055/s-0037-1614368 / Thromb Haemost / Reevaluation of the incidence of thromboembolic complications in congenital factor XII deficiency‐a study on 73 subjects from 14 Swiss families by Zeerleder (1999)
10.1023/B:THRO.0000037670.42776.cd / J Thromb Thrombolysis / The occasional venous thromboses seen in patients with severe (homozygous) FXII deficiency are probably due to associated risk factors: a study of prevalence in 21 Patients and review of the literature by Girolami (2004)
10.1161/01.ATV.17.10.2103 / Arterisocler Thromb Vasc Biol / Risk of coronary heart disease and activation of factor XII in middle aged men by Miller (1997)
10.1016/j.ahj.2003.07.012 / Am Heart J / Activated factor XII (FXIIa) predicts recurrent coronary events after acute myocardial infarction by Grundt (2004)
{'key': '10.1111/j.1538-7836.2007.02446.x_bb0325', 'first-page': 'A30', 'article-title': 'Plasma activity of coagulation factor XII and all cause mortality in Vienna (ACMIV study) – evidence of a J‐shaped association of factor XII activity and overall survival', 'volume': '26', 'author': 'Endler', 'year': '2006', 'journal-title': 'Hämostasiologie'} / Hämostasiologie / Plasma activity of coagulation factor XII and all cause mortality in Vienna (ACMIV study) – evidence of a J‐shaped association of factor XII activity and overall survival by Endler (2006)
10.1182/blood-2005-02-0577 / Blood / The effects of intrinsic pathway protease deficiencies on plasminogen‐deficient mice by Cheng (2005)
10.1101/gad.9.7.794 / Genes Develop / Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction by Bugge (1995)
10.1016/S0002-9440(10)64529-4 / Am J Path / The development of bleomycin‐induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system by Swaisgood (2000)

Dates

Type	When
Created	18 years, 2 months ago (May 26, 2007, 11:32 a.m.)
Deposited	2 years, 7 months ago (Jan. 15, 2023, 10:19 p.m.)
Indexed	2 weeks, 2 days ago (Aug. 6, 2025, 8:42 a.m.)
Issued	18 years, 2 months ago (June 1, 2007)
Published	18 years, 2 months ago (June 1, 2007)
Published Print	18 years, 2 months ago (June 1, 2007)

Funders 0

None

BibTeX

@article{GAILANI_2007, title={The intrinsic pathway of coagulation: a target for treating thromboembolic disease?}, volume={5}, ISSN={1538-7836}, url={http://dx.doi.org/10.1111/j.1538-7836.2007.02446.x}, DOI={10.1111/j.1538-7836.2007.02446.x}, number={6}, journal={Journal of Thrombosis and Haemostasis}, publisher={Elsevier BV}, author={GAILANI, D. and RENNÉ, T.}, year={2007}, month=jun, pages={1106–1112} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        6
      ]
    ],
    "date-time": "2025-08-06T12:42:21Z",
    "timestamp": 1754484141082
  },
  "reference-count": 67,
  "publisher": "Elsevier BV",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2007,
            6,
            1
          ]
        ],
        "date-time": "2007-06-01T00:00:00Z",
        "timestamp": 1180656000000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2022,
            12,
            7
          ]
        ],
        "date-time": "2022-12-07T00:00:00Z",
        "timestamp": 1670371200000
      },
      "content-version": "vor",
      "delay-in-days": 5668,
      "URL": "http://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [
      "elsevier.com",
      "sciencedirect.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2007,
        6
      ]
    ]
  },
  "DOI": "10.1111/j.1538-7836.2007.02446.x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2007,
        5,
        26
      ]
    ],
    "date-time": "2007-05-26T15:32:24Z",
    "timestamp": 1180193544000
  },
  "page": "1106-1112",
  "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy",
  "source": "Crossref",
  "is-referenced-by-count": 163,
  "title": "The intrinsic pathway of coagulation: a target for treating thromboembolic disease?",
  "prefix": "10.1016",
  "volume": "5",
  "author": [
    {
      "given": "D.",
      "family": "GAILANI",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "T.",
      "family": "RENN\u00c9",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0010",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1182/blood.V70.1.1.1",
      "article-title": "The coagulation\u2010kinin pathway of human plasma",
      "volume": "70",
      "author": "Kaplan",
      "year": "1987",
      "journal-title": "Blood"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0015",
      "doi-asserted-by": "crossref",
      "first-page": "241",
      "DOI": "10.1016/S0065-2776(08)60837-8",
      "article-title": "The biochemistry and pathophysiology of the contact system of plasma",
      "volume": "33",
      "author": "Cochrane",
      "year": "1982",
      "journal-title": "Adv Immunol"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0020",
      "doi-asserted-by": "crossref",
      "first-page": "225",
      "DOI": "10.1016/S0065-2776(08)60599-4",
      "article-title": "The intrinsic coagulation/kinin\u2010forming cascade: assembly in plasma and cell surfaces in inflammation",
      "volume": "66",
      "author": "Kaplan",
      "year": "1997",
      "journal-title": "Adv Immunol"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0025",
      "doi-asserted-by": "crossref",
      "first-page": "3819",
      "DOI": "10.1182/blood.V90.10.3819",
      "article-title": "Contact system: a vascular biology modulator with anticoagulant, profibrinolytic, antiadhesive, and proinflammatory attributes",
      "volume": "90",
      "author": "Colman",
      "year": "1997",
      "journal-title": "Blood"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0030",
      "doi-asserted-by": "crossref",
      "first-page": "498",
      "DOI": "10.1038/202498a0",
      "article-title": "An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier",
      "volume": "202",
      "author": "Macfarlane",
      "year": "1964",
      "journal-title": "Nature"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0035",
      "doi-asserted-by": "crossref",
      "first-page": "1310",
      "DOI": "10.1126/science.145.3638.1310",
      "article-title": "Waterfall sequence for intrinsic clotting",
      "volume": "145",
      "author": "Davie",
      "year": "1964",
      "journal-title": "Science"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0040",
      "doi-asserted-by": "crossref",
      "first-page": "10363",
      "DOI": "10.1021/bi00107a001",
      "article-title": "The coagulation cascade: initiation, maintenance and regulation",
      "volume": "30",
      "author": "Davie",
      "year": "1991",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0045",
      "series-title": "Hematology: Basic Principles and Practice",
      "first-page": "2001",
      "article-title": "Laboratory evaluation of hemostatic disorders",
      "author": "Rand",
      "year": "2005"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0050",
      "doi-asserted-by": "crossref",
      "first-page": "4892",
      "DOI": "10.1074/jbc.M105221200",
      "article-title": "Characterization of the H\u2010kininogen\u2010binding site on factor XI: a comparison of factor XI and plasma prekallikrein",
      "volume": "277",
      "author": "Renne",
      "year": "2002",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0055",
      "series-title": "Hematology: Basic Principles and Practice",
      "first-page": "2047",
      "article-title": "Clinical aspects and therapy of hemophilia",
      "author": "Lozier",
      "year": "2005"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0060",
      "doi-asserted-by": "crossref",
      "first-page": "153",
      "DOI": "10.1056/NEJM199107183250303",
      "article-title": "Factor XI deficiency in Ashkenazi Jews in Israel",
      "volume": "325",
      "author": "Asakai",
      "year": "1991",
      "journal-title": "N Eng J Med"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0065",
      "series-title": "The Metabolic and Molecular Bases of Inherited Disease",
      "first-page": "4433",
      "article-title": "Factor XI and the contact system",
      "author": "Gailani",
      "year": "2001"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0070",
      "doi-asserted-by": "crossref",
      "first-page": "3962",
      "DOI": "10.1182/blood.V90.10.3962",
      "article-title": "A coagulation factor IX\u2010deficient mouse model for human hemophilia B",
      "volume": "90",
      "author": "Lin",
      "year": "1997",
      "journal-title": "Blood"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0075",
      "doi-asserted-by": "crossref",
      "first-page": "134",
      "DOI": "10.1097/00001721-199703000-00008",
      "article-title": "A murine model of factor XI deficiency",
      "volume": "8",
      "author": "Gailani",
      "year": "1997",
      "journal-title": "Blood Coag Fibrinol"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0080",
      "doi-asserted-by": "crossref",
      "first-page": "503",
      "DOI": "10.1160/TH04-04-0250",
      "article-title": "Targeted deletion of murine coagulation factor XII gene\u2010a model for contact phase activation in\u00a0vivo",
      "volume": "92",
      "author": "Pauer",
      "year": "2004",
      "journal-title": "Thromb Haemost"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0085",
      "doi-asserted-by": "crossref",
      "first-page": "7527",
      "DOI": "10.1073/pnas.0932632100",
      "article-title": "The evolution of vertebrate coagulation as viewed from a comparison of puffer fish and sea squirt genomes",
      "volume": "100",
      "author": "Jiang",
      "year": "2003",
      "journal-title": "Proc Nat Acad Sci USA"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0090",
      "doi-asserted-by": "crossref",
      "first-page": "31",
      "DOI": "10.1016/S0049-3848(97)00307-1",
      "article-title": "Whale Hageman factor (factor XII): prevented production due to pseudogene conversion",
      "volume": "90",
      "author": "Semba",
      "year": "1998",
      "journal-title": "Thromb Res"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0095",
      "doi-asserted-by": "crossref",
      "first-page": "7539",
      "DOI": "10.1021/bi00485a001",
      "article-title": "Regulation of coagulation by a multivalent Kunitz\u2010type inhibitor",
      "volume": "29",
      "author": "Broze",
      "year": "1990",
      "journal-title": "Biochem"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0100",
      "doi-asserted-by": "crossref",
      "first-page": "17241",
      "DOI": "10.1074/jbc.M312827200",
      "article-title": "Formation of factor IXa and Xa by the extrinsic pathway: differential regulation by tissue factor pathway inhibitor and antithrombin",
      "volume": "279",
      "author": "Lu",
      "year": "2004",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0105",
      "doi-asserted-by": "crossref",
      "first-page": "123",
      "DOI": "10.1182/blood-2003-12-4352",
      "article-title": "Platelet deposition inhibits tissue factor activity: in\u00a0vitro clots are impermeable to factor Xa",
      "volume": "104",
      "author": "Hathcock",
      "year": "2004",
      "journal-title": "Blood"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0110",
      "doi-asserted-by": "crossref",
      "first-page": "3190",
      "DOI": "10.1182/blood-2004-03-0935",
      "article-title": "Hematopoietic cell\u2010derived microparticle tissue factor contributes to fibrin formation during thrombus propagation",
      "volume": "104",
      "author": "Chou",
      "year": "2004",
      "journal-title": "Blood"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0115",
      "doi-asserted-by": "crossref",
      "first-page": "192",
      "DOI": "10.1182/blood-2004-06-2225",
      "article-title": "Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall",
      "volume": "105",
      "author": "Day",
      "year": "2005",
      "journal-title": "Blood"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0120",
      "doi-asserted-by": "crossref",
      "first-page": "2271",
      "DOI": "10.1021/bi972113+",
      "article-title": "Prothrombin is a cofactor for binding of factor XI to the platelet surface and for platelet\u2010mediated factor XI activation by thrombin",
      "volume": "37",
      "author": "Baglia",
      "year": "1998",
      "journal-title": "Biochem"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0125",
      "doi-asserted-by": "crossref",
      "first-page": "20514",
      "DOI": "10.1074/jbc.M000464200",
      "article-title": "Thrombin\u2010mediated feedback activation of factor XI on the activated platelet surface is preferred over contact activation by factor XIIa or factor XIa",
      "volume": "275",
      "author": "Baglia",
      "year": "2000",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0130",
      "doi-asserted-by": "crossref",
      "first-page": "909",
      "DOI": "10.1126/science.1652157",
      "article-title": "Factor XI activation in a revised model of blood coagulation",
      "volume": "253",
      "author": "Gailani",
      "year": "1991",
      "journal-title": "Science"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0135",
      "doi-asserted-by": "crossref",
      "first-page": "3035",
      "DOI": "10.1182/blood.V86.8.3035.3035",
      "article-title": "Feedback activation of factor XI by thrombin in plasma results in additional formation of thrombin that protects fibrin clots from fibrinolysis",
      "volume": "86",
      "author": "Von Dem Borne",
      "year": "1995",
      "journal-title": "Blood"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0140",
      "doi-asserted-by": "crossref",
      "first-page": "14477",
      "DOI": "10.1074/jbc.270.24.14477",
      "article-title": "Purification and characterization of thrombin activatable fibrinolysis inhibitor (TAFI), a thrombin\u2010activatable fibrinolysis inhibitor",
      "volume": "270",
      "author": "Bajzar",
      "year": "1995",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0145",
      "doi-asserted-by": "crossref",
      "first-page": "2323",
      "DOI": "10.1172/JCI119412",
      "article-title": "Thrombin\u2010mediated activation of factor XI results in a thrombin\u2010activatable fibrinolysis inhibitor\u2010dependent inhibition of fibrinolysis",
      "volume": "99",
      "author": "Von dem Borne",
      "year": "1997",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0150",
      "doi-asserted-by": "crossref",
      "first-page": "1060",
      "DOI": "10.1055/s-0037-1615964",
      "article-title": "The role of factor XI in thrombin generation induced by low concentrations of tissue factor",
      "volume": "85",
      "author": "Keularts",
      "year": "2001",
      "journal-title": "Thromb Haemost"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0155",
      "doi-asserted-by": "crossref",
      "first-page": "4581",
      "DOI": "10.1182/blood.V91.12.4581",
      "article-title": "Blood coagulation in hemophilia A and hemophilia C",
      "volume": "91",
      "author": "Cawthern",
      "year": "1998",
      "journal-title": "Blood"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0160",
      "doi-asserted-by": "crossref",
      "first-page": "903",
      "DOI": "10.1073/pnas.0507195103",
      "article-title": "Polyphosphate modulates blood coagulation and fibrinolysis",
      "volume": "103",
      "author": "Smith",
      "year": "2006",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0165",
      "doi-asserted-by": "crossref",
      "first-page": "271",
      "DOI": "10.1084/jem.20050664",
      "article-title": "Defective thrombus formation in mice lacking coagulation factor XII",
      "volume": "202",
      "author": "Renne",
      "year": "2005",
      "journal-title": "J Exp Med"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0170",
      "first-page": "347",
      "article-title": "Activation of blood clotting factors by microbial proteinases",
      "volume": "121",
      "author": "Kaminishi",
      "year": "1994",
      "journal-title": "FEBS Microbiol Lett"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0175",
      "doi-asserted-by": "crossref",
      "first-page": "1415",
      "DOI": "10.1084/jem.192.10.1415",
      "article-title": "Severe lung lesions caused by Salmonella are prevented by inhibition of the contact system",
      "volume": "192",
      "author": "Persson",
      "year": "2000",
      "journal-title": "J Exp Med"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0180",
      "doi-asserted-by": "crossref",
      "first-page": "11982",
      "DOI": "10.1016/S0021-9258(19)50297-6",
      "article-title": "Human Hageman factor (factor XII) and high molecular weight kininogen compete for the same binding site on human umbilical vein endothelial cells",
      "volume": "268",
      "author": "Reddigari",
      "year": "1987",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0185",
      "doi-asserted-by": "crossref",
      "first-page": "3377",
      "DOI": "10.4049/jimmunol.175.5.3377",
      "article-title": "Local bradykinin formation is controlled by glycosaminoglycans",
      "volume": "175",
      "author": "Renne",
      "year": "2005",
      "journal-title": "J Immunol"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0190",
      "doi-asserted-by": "crossref",
      "first-page": "226",
      "DOI": "10.1055/s-0037-1615837",
      "article-title": "Activation of the plasma/kallikrein system on cells: a revised hypothesis",
      "volume": "82",
      "author": "Schmaier",
      "year": "1999",
      "journal-title": "Thromb Haemost"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0195",
      "doi-asserted-by": "crossref",
      "first-page": "896",
      "DOI": "10.1073/pnas.022626899",
      "article-title": "Heat shock protein 90 catalyzes activation of the prekallikrein\u2010kininogen complex in the absence of factor XII",
      "volume": "99",
      "author": "Joseph",
      "year": "2002",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0200",
      "doi-asserted-by": "crossref",
      "first-page": "4554",
      "DOI": "10.1182/blood-2003-07-2510",
      "article-title": "Recombinant prolylcarboxypeptidase activates plasma prekallikrein",
      "volume": "103",
      "author": "Shariat\u2010Madar",
      "year": "2004",
      "journal-title": "Blood"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0205",
      "doi-asserted-by": "crossref",
      "first-page": "33224",
      "DOI": "10.1074/jbc.273.50.33224",
      "article-title": "A novel mechanism for bradykinin production at inflammatory sites. Diverse effects of a mixture of neutrophil elastase and mast cell tryptase versus tissue and plasma kallikreins on native and oxidized kininogens",
      "volume": "273",
      "author": "Kozik",
      "year": "1998",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0210",
      "doi-asserted-by": "crossref",
      "first-page": "695",
      "DOI": "10.1111/j.1538-7836.2005.01236.x",
      "article-title": "Effects of factor IX or factor XI deficiency on ferric chloride\u2010induced carotid artery occlusion in mice",
      "volume": "3",
      "author": "Wang",
      "year": "2005",
      "journal-title": "J Thromb Haemost"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0215",
      "doi-asserted-by": "crossref",
      "first-page": "101",
      "DOI": "10.1172/JCI0212119",
      "article-title": "Thrombin\u2010activatable fibrinolysis inhibitor (TAFI) deficiency is compatible with murine life",
      "volume": "109",
      "author": "Nagashima",
      "year": "2002",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0220",
      "doi-asserted-by": "crossref",
      "first-page": "3355",
      "DOI": "10.1172/JCI26987",
      "article-title": "Thrombus formation in\u00a0vivo",
      "volume": "115",
      "author": "Furie",
      "year": "2005",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0225",
      "first-page": "66a",
      "article-title": "Factor XI deficient mice have reduced platelet accumulation and fibrin deposition after laser injury",
      "volume": "104",
      "author": "Baird",
      "year": "2004",
      "journal-title": "Blood"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0230",
      "doi-asserted-by": "crossref",
      "first-page": "774",
      "DOI": "10.1055/s-0037-1613081",
      "article-title": "FXI is essential for thrombus formation following FeCl3\u2010induced injury of the carotid artery in the mouse",
      "volume": "87",
      "author": "Rosen",
      "year": "2002",
      "journal-title": "Thromb Haemost"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0235",
      "doi-asserted-by": "crossref",
      "first-page": "513",
      "DOI": "10.1084/jem.20052458",
      "article-title": "Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis",
      "volume": "203",
      "author": "Kleinschnitz",
      "year": "2006",
      "journal-title": "J Exp Med"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0240",
      "doi-asserted-by": "crossref",
      "first-page": "91",
      "DOI": "10.1084/jem.190.1.91",
      "article-title": "Targeted inhibition of intrinsic coagulation limits cerebral injury in stroke without increasing intracerebral hemorrhage",
      "volume": "190",
      "author": "Choudhri",
      "year": "1999",
      "journal-title": "J Exp Med"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0245",
      "doi-asserted-by": "crossref",
      "first-page": "186",
      "DOI": "10.1055/s-0037-1613209",
      "article-title": "Platelet activation and blood coagulation",
      "volume": "88",
      "author": "Heemskerk",
      "year": "2002",
      "journal-title": "Thromb Haemost"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0250",
      "doi-asserted-by": "crossref",
      "first-page": "106",
      "DOI": "10.1182/blood.V57.1.106.106",
      "article-title": "Contributions of human platelets to the proteolytic activation of blood coagulation factors XII and XI",
      "volume": "57",
      "author": "Walsh",
      "year": "1981",
      "journal-title": "Blood"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0255",
      "doi-asserted-by": "crossref",
      "first-page": "173",
      "DOI": "10.1515/BC.2006.023",
      "article-title": "Platelets promote coagulation factor XII\u2010mediated proteolytic cascade systems in plasma",
      "volume": "387",
      "author": "Johne",
      "year": "2006",
      "journal-title": "Biol Chem"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0260",
      "doi-asserted-by": "crossref",
      "first-page": "696",
      "DOI": "10.1056/NEJM200003093421004",
      "article-title": "High levels of coagulation factor XI as a risk factor for venous thrombosis",
      "volume": "342",
      "author": "Meijers",
      "year": "2000",
      "journal-title": "N Engl J Med"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0265",
      "doi-asserted-by": "crossref",
      "first-page": "4045",
      "DOI": "10.1182/blood-2005-12-023697",
      "article-title": "Levels of intrinsic coagulation factors and the risk of myocardial infarction among men. Opposite and synergistic effects of factors XI and XII",
      "volume": "108",
      "author": "Doggen",
      "year": "2006",
      "journal-title": "Blood"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0270",
      "doi-asserted-by": "crossref",
      "first-page": "658",
      "DOI": "10.1046/j.1538-7836.2003.00195.x",
      "article-title": "Inherited factor XI deficiency confers no protection against acute myocardial infarction",
      "volume": "1",
      "author": "Salomon",
      "year": "2003",
      "journal-title": "J Thromb Haemost"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0275",
      "doi-asserted-by": "crossref",
      "first-page": "411",
      "DOI": "10.1309/QC259F09UNMKVP0R",
      "article-title": "Elevated factor XI activity levels are associated with an increased odds ratio for cerebrovascular events",
      "volume": "126",
      "author": "Yang",
      "year": "2006",
      "journal-title": "Am J Clin Pathol"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0280",
      "doi-asserted-by": "crossref",
      "first-page": "10",
      "DOI": "10.1172/JCI781",
      "article-title": "Enhancement of rabbit jugular vein thrombolysis by neutralization of factor XI. In\u00a0vivo evidence for a role of factor XI as an anti\u2010fibrinolytic factor",
      "volume": "101",
      "author": "Minnema",
      "year": "1998",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0285",
      "doi-asserted-by": "crossref",
      "first-page": "1496",
      "DOI": "10.1111/j.1538-7836.2006.01973.x",
      "article-title": "Factor XI contributes to thrombus propagation on injured neointima of the rabbit iliac artery",
      "volume": "4",
      "author": "Yamashita",
      "year": "2006",
      "journal-title": "J Thromb Haemost"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0290",
      "doi-asserted-by": "crossref",
      "first-page": "953",
      "DOI": "10.1182/blood-2003-01-0324",
      "article-title": "Factor XI\u2010dependence of surface\u2010 and tissue factor\u2010initiated thrombus formation in primates",
      "volume": "102",
      "author": "Gruber",
      "year": "2003",
      "journal-title": "Blood"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0295",
      "first-page": "151",
      "article-title": "The George M. Kober lecture. The legacy of John Hageman: new dividends",
      "volume": "98",
      "author": "Ratnoff",
      "year": "1985",
      "journal-title": "Trans Assoc Am Physicians"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0300",
      "doi-asserted-by": "crossref",
      "first-page": "422",
      "DOI": "10.1111/j.1365-2141.1994.tb04937.x",
      "article-title": "John Hageman\u2019s factor and deep\u2010vein thrombosis: Leiden thrombophilia Study",
      "volume": "87",
      "author": "Koster",
      "year": "1994",
      "journal-title": "Br J Haematol"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0305",
      "doi-asserted-by": "crossref",
      "first-page": "1240",
      "DOI": "10.1055/s-0037-1614368",
      "article-title": "Reevaluation of the incidence of thromboembolic complications in congenital factor XII deficiency\u2010a study on 73 subjects from 14 Swiss families",
      "volume": "82",
      "author": "Zeerleder",
      "year": "1999",
      "journal-title": "Thromb Haemost"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0310",
      "doi-asserted-by": "crossref",
      "first-page": "139",
      "DOI": "10.1023/B:THRO.0000037670.42776.cd",
      "article-title": "The occasional venous thromboses seen in patients with severe (homozygous) FXII deficiency are probably due to associated risk factors: a study of prevalence in 21 Patients and review of the literature",
      "volume": "17",
      "author": "Girolami",
      "year": "2004",
      "journal-title": "J Thromb Thrombolysis"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0315",
      "doi-asserted-by": "crossref",
      "first-page": "2103",
      "DOI": "10.1161/01.ATV.17.10.2103",
      "article-title": "Risk of coronary heart disease and activation of factor XII in middle aged men",
      "volume": "17",
      "author": "Miller",
      "year": "1997",
      "journal-title": "Arterisocler Thromb Vasc Biol"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0320",
      "doi-asserted-by": "crossref",
      "first-page": "260",
      "DOI": "10.1016/j.ahj.2003.07.012",
      "article-title": "Activated factor XII (FXIIa) predicts recurrent coronary events after acute myocardial infarction",
      "volume": "147",
      "author": "Grundt",
      "year": "2004",
      "journal-title": "Am Heart J"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0325",
      "first-page": "A30",
      "article-title": "Plasma activity of coagulation factor XII and all cause mortality in Vienna (ACMIV study) \u2013 evidence of a J\u2010shaped association of factor XII activity and overall survival",
      "volume": "26",
      "author": "Endler",
      "year": "2006",
      "journal-title": "H\u00e4mostasiologie"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0330",
      "doi-asserted-by": "crossref",
      "first-page": "3055",
      "DOI": "10.1182/blood-2005-02-0577",
      "article-title": "The effects of intrinsic pathway protease deficiencies on plasminogen\u2010deficient mice",
      "volume": "106",
      "author": "Cheng",
      "year": "2005",
      "journal-title": "Blood"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0335",
      "doi-asserted-by": "crossref",
      "first-page": "794",
      "DOI": "10.1101/gad.9.7.794",
      "article-title": "Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction",
      "volume": "9",
      "author": "Bugge",
      "year": "1995",
      "journal-title": "Genes Develop"
    },
    {
      "key": "10.1111/j.1538-7836.2007.02446.x_bb0340",
      "doi-asserted-by": "crossref",
      "first-page": "177",
      "DOI": "10.1016/S0002-9440(10)64529-4",
      "article-title": "The development of bleomycin\u2010induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system",
      "volume": "157",
      "author": "Swaisgood",
      "year": "2000",
      "journal-title": "Am J Path"
    }
  ],
  "container-title": "Journal of Thrombosis and Haemostasis",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1538-7836.2007.02446.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S153878362210200X?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S153878362210200X?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1538-7836.2007.02446.x/fullpdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        1,
        16
      ]
    ],
    "date-time": "2023-01-16T03:19:46Z",
    "timestamp": 1673839186000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S153878362210200X"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2007,
        6
      ]
    ]
  },
  "references-count": 67,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          2007,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "S153878362210200X"
  ],
  "URL": "http://dx.doi.org/10.1111/j.1538-7836.2007.02446.x",
  "relation": {},
  "ISSN": [
    "1538-7836"
  ],
  "subject": [],
  "container-title-short": "Journal of Thrombosis and Haemostasis",
  "published": {
    "date-parts": [
      [
        2007,
        6
      ]
    ]
  },
  "assertion": [
    {
      "value": "Elsevier",
      "name": "publisher",
      "label": "This article is maintained by"
    },
    {
      "value": "The intrinsic pathway of coagulation: a target for treating thromboembolic disease?",
      "name": "articletitle",
      "label": "Article Title"
    },
    {
      "value": "Journal of Thrombosis and Haemostasis",
      "name": "journaltitle",
      "label": "Journal Title"
    },
    {
      "value": "https://doi.org/10.1111/j.1538-7836.2007.02446.x",
      "name": "articlelink",
      "label": "CrossRef DOI link to publisher maintained version"
    },
    {
      "value": "article",
      "name": "content_type",
      "label": "Content Type"
    },
    {
      "value": "Copyright \u00a9 2007 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.",
      "name": "copyright",
      "label": "Copyright"
    }
  ]
}