DOI: 10.1111/j.1532-5415.1996.tb05641.x. Evaluation of Four Methods for the Diagnosis of Respiratory Syncytial Virus Infection in Older Adults

Evaluation of Four Methods for the Diagnosis of Respiratory Syncytial Virus Infection in Older Adults

10.1111/j.1532-5415.1996.tb05641.x

Crossref journal-article

Wiley

Journal of the American Geriatrics Society (311)

Abstract

OBJECTIVE: To evaluate four methods of rapid diagnosis of respiratory syncytial virus (RSV) infection in older adults and to compare sensitivities with serologic analysis.DESIGN: Prospective comparative analysis.SETTING: Two adult daycenters.PATIENTS: Frail older persons attending the daycenter who developed signs or symptoms of acute respiratory illness between the months of December and February.MEASUREMENTS: Viral cultures performed by standard technique and bedside inoculation: antigen detection by indirect immunofluorescence assay (IFA) and Directigen enzyme immunoassay (EIA) on nasal brush samples; serologic analysis of acute and convalescent sera using EIA.RESULTS: RSV infection was documented by serology in 11 of 54 (20%) subjects during the study period. Bedside viral cultures were the most sensitive assay and were positive in 6/9 infections. Standard viral culture detected 5/11 cases. Both methods of rapid antigen detection were found to be insensitive, with 1/11 detected by IFA and 0/11 detected by EIA.CONCLUSION: Rapid antigen tests for the diagnosis of RSV in older persons should be used with caution. J Am Geriatr Soc 44:71–73, 1996.

Bibliography

Falsey, A. R., McCann, R. M., Hall, W. J., & Criddle, M. M. (1996). Evaluation of Four Methods for the Diagnosis of Respiratory Syncytial Virus Infection in Older Adults. Journal of the American Geriatrics Society, 44(1), 71â73. Portico.

Authors 4

Ann R. Falsey (first)
Robert M. McCann (additional)
William J. Hall (additional)
Mary M. Criddle (additional)

References 11 Referenced 58

10.1056/NEJM197303082881005
10.7326/0003-4819-109-3-203
10.1016/S0163-4453(84)90530-9
10.1016/S0140-6736(05)80082-0
10.1093/infdis/172.2.389
10.1007/BF01961862
10.1128/jcm.17.6.1099-1101.1983 / J Clin Microbiol / Rapid detection of respiratory syncytial virus with a monoclonal antibody by Bell DM (1983)
10.1093/infdis/157.4.640
10.1093/infdis/162.2.568
EnglundJA PiedraPA JewellAet al.Rapid diagnosis of respiratory syncytial virus (RSV) infection in immunocompromised adults. Abstract #H36. 34th Interscience Conference on Antimicrobial Agents and Chemotherapy. Orlando FL October 1995.
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Dates

Type	When
Created	10 years, 3 months ago (April 28, 2015, 7:57 p.m.)
Deposited	1 year, 9 months ago (Oct. 27, 2023, 3:15 p.m.)
Indexed	4 months, 1 week ago (April 15, 2025, 7:34 a.m.)
Issued	29 years, 7 months ago (Jan. 1, 1996)
Published	29 years, 7 months ago (Jan. 1, 1996)
Published Online	10 years, 3 months ago (April 27, 2015)
Published Print	29 years, 7 months ago (Jan. 1, 1996)

Funders 0

None

BibTeX

@article{Falsey_1996, title={Evaluation of Four Methods for the Diagnosis of Respiratory Syncytial Virus Infection in Older Adults}, volume={44}, ISSN={1532-5415}, url={http://dx.doi.org/10.1111/j.1532-5415.1996.tb05641.x}, DOI={10.1111/j.1532-5415.1996.tb05641.x}, number={1}, journal={Journal of the American Geriatrics Society}, publisher={Wiley}, author={Falsey, Ann R. and McCann, Robert M. and Hall, William J. and Criddle, Mary M.}, year={1996}, month=jan, pages={71–73} }

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