DOI: 10.1111/j.1532-5415.1996.tb01399.x. Relationship Between Baseline Insulin‐Like Growth Factor‐I (IGF‐I) and Femoral Bone Density in Women Aged Over 70 Years: Potential Implications for the Prevention of Age‐Related Bone Loss

Relationship Between Baseline Insulin‐Like Growth Factor‐I (IGF‐I) and Femoral Bone Density in Women Aged Over 70 Years: Potential Implications for the Prevention of Age‐Related Bone Loss

10.1111/j.1532-5415.1996.tb01399.x

Crossref journal-article

Wiley

Journal of the American Geriatrics Society (311)

Abstract

OBJECTIVE: To test the hypothesis that the decline in femoral bone mass associated with healthy aging is partially accounted for by deficiency of the growth hormone‐insulinlike growth factor‐I (IGF‐I) axis.DESIGN: Cross‐sectional study.STUDY PARTICIPANTS: A sample of 245 community‐dwelling healthy women aged 70 and older. Exclusion criteria were diseases or medications known to affect the musculoskeletal system or the somatotrophic axis.MEASUREMENTS: Serum levels of IGF‐I, calcitriol, and osteocalcin were determined by radioimmunoassay; serum calcidiol was measured by competitive binding assay, and serum parathyroid hormone (PTH) was assessed immuno‐chemically. Urinary pyridinium crosslinks were measured by fluorescent detection after high‐pressure liquid chromatography. Isometric and isokinetic quadriceps strength was evaluated using an isokinetic dynamometer. Bone density (BMD) was assessed by dual‐energy X‐ray absorptiometry at the proximal femur. Multiple regression was used to adjust for potential confounders.RESULTS: At the proximal femur, BMD declined by 0.59–0.84% per year. In addition to body mass index and muscle strength, serum IGF‐I was found to be an independent predictor of BMD at all femoral sites.CONCLUSION: The data support the hypothesis that circulating IGF‐I not only reflects the integrated growth hormone secretion but also has a direct role in the endocrine regulation of bone remodeling. The present findings support the need for further studies to assess the potential of IGF‐I in attenuating age‐related femoral bone loss. J Am Geriatr Soc 44:1301–1306, 1996.

Bibliography

Boonen, S., Lesaffre, E., Dequeker, J., Aerssens, J., Nijs, J., Pelemans, W., & Bouillon, R. (1996). Relationship Between Baseline InsulinâLike Growth FactorâI (IGFâI) and Femoral Bone Density in Women Aged Over 70 Years: Potential Implications for the Prevention of AgeâRelated Bone Loss. Journal of the American Geriatrics Society, 44(11), 1301â1306. Portico.

Authors 7

Steven Boonen (first)
Emmanuel Lesaffre (additional)
Jan Dequeker (additional)
Jeroen Aerssens (additional)
Jos Nijs (additional)
Walter Pelemans (additional)
Roger Bouillon (additional)

References 55 Referenced 66

10.1093/oxfordjournals.epirev.a036281
10.1016/8756-3282(93)90341-7
10.3109/17453677608988727
10.1007/BF02555036
10.1002/jbmr.5650070608
10.1016/0140-6736(93)92555-8
10.1210/jcem-64-5-884
10.1210/jcem-72-1-172
10.1172/JCI110164
10.1016/S0300-595X(84)80011-0
10.1159/000182189
10.1210/jcem-48-2-271
10.1210/edrv-14-1-20
10.1210/endo-125-4-2118
10.1210/endo-122-1-254
10.1002/jbmr.5650051013
10.1210/jc.78.5.1009
10.1016/0026-0495(87)90200-9
10.1007/BF01621884
10.1210/jc.78.5.1011
{'key': 'e_1_2_6_22_2', 'first-page': '75', 'article-title': 'Design and development of a questionnaire for use in a multicentre study of vertebral osteoporosis in Europe: The European Vertebral Osteoporosis Study (EVOS)', 'volume': '24', 'author': "O'Neill TW", 'year': '1995', 'journal-title': 'Rheumatology in Europe'} / Rheumatology in Europe / Design and development of a questionnaire for use in a multicentre study of vertebral osteoporosis in Europe: The European Vertebral Osteoporosis Study (EVOS) by O'Neill TW (1995)
10.1016/S0002-8223(21)02098-8 / J Am Diet Assoc / A simple method for assessing calcium intake in Caucasian women by Angus R (1989)
10.1159/000180580
10.1210/jc.75.2.494
10.1093/clinchem/22.3.364 / Clin Chem / Measurement of 25‐hydroxyvitamin D3 in serum by Bouillon R (1976)
10.1210/jcem-45-2-225
10.1093/clinchem/26.5.562 / Clin Chem / A radioimmunoassay for 1,25‐dihydroxycholecalciferol by Bouillon R (1980)
10.1172/JCI110072
10.1093/clinchem/36.2.271 / Clin Chem / Immunoradiometric assay of parathyrin with polyclonal and monoclonal region‐specific antibodies by Bouillon R (1990)
10.1016/0022-4731(82)90206-0
10.1093/clinchem/38.10.2055 / Clin Chem / Homologous radioimmunoassay of human osteocalcin by Bouillon R (1992)
10.1016/S0169-6009(08)80057-8
10.1002/9780470316863
10.1002/jbmr.5650100806
10.1007/BF02553698
{'key': 'e_1_2_6_37_2', 'first-page': '441', 'article-title': 'Muscle strength, physical fitness, and weight, but not age predict femoral neck bone mass', 'volume': '3', 'author': 'Pocock N', 'year': '1988', 'journal-title': 'J Bone Miner Res'} / J Bone Miner Res / Muscle strength, physical fitness, and weight, but not age predict femoral neck bone mass by Pocock N (1988)
10.1002/jbmr.5650081205
10.1002/jbmr.5650090107
10.1007/BF00298715
10.1111/j.1365-2796.1992.tb00550.x
10.1002/jbmr.5650090617
10.1111/j.1365-2265.1994.tb03018.x
10.1210/jcem-59-4-701
10.1016/S0169-6009(08)80250-4
10.1002/jbmr.5650070511
10.1002/jbmr.5650070606
10.1002/jbmr.5650091208
10.1007/BF01622192
10.1210/jc.77.5.1384
10.1002/jbmr.5650101203
10.1016/0002-9343(83)90860-4
10.1136/bmj.305.6848.273
10.1002/jbmr.5650071003
10.1007/BF03187466
10.1093/ageing/23.3.185

Dates

Type	When
Created	10 years, 4 months ago (April 28, 2015, 9:09 p.m.)
Deposited	1 year, 11 months ago (Sept. 28, 2023, 3:04 a.m.)
Indexed	1 year, 1 month ago (July 26, 2024, 3:15 a.m.)
Issued	28 years, 10 months ago (Nov. 1, 1996)
Published	28 years, 10 months ago (Nov. 1, 1996)
Published Online	10 years, 4 months ago (April 27, 2015)
Published Print	28 years, 10 months ago (Nov. 1, 1996)

Funders 0

None

BibTeX

@article{Boonen_1996, title={Relationship Between Baseline Insulin‐Like Growth Factor‐I (IGF‐I) and Femoral Bone Density in Women Aged Over 70 Years: Potential Implications for the Prevention of Age‐Related Bone Loss}, volume={44}, ISSN={1532-5415}, url={http://dx.doi.org/10.1111/j.1532-5415.1996.tb01399.x}, DOI={10.1111/j.1532-5415.1996.tb01399.x}, number={11}, journal={Journal of the American Geriatrics Society}, publisher={Wiley}, author={Boonen, Steven and Lesaffre, Emmanuel and Dequeker, Jan and Aerssens, Jeroen and Nijs, Jos and Pelemans, Walter and Bouillon, Roger}, year={1996}, month=nov, pages={1301–1306} }

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  },
  "references-count": 55,
  "journal-issue": {
    "issue": "11",
    "published-print": {
      "date-parts": [
        [
          1996,
          11
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1111/j.1532-5415.1996.tb01399.x"
  ],
  "URL": "http://dx.doi.org/10.1111/j.1532-5415.1996.tb01399.x",
  "relation": {},
  "ISSN": [
    "0002-8614",
    "1532-5415"
  ],
  "subject": [],
  "container-title-short": "J American Geriatrics Society",
  "published": {
    "date-parts": [
      [
        1996,
        11
      ]
    ]
  }
}