DOI: 10.1111/j.1530-0277.1996.tb01739.x. Progression of Type C Chronic Hepatitis to Liver Cirrhosis and Hepatocellular Carcinoma—Its Relationship to Alcohol Drinking and the Age of Transfusion

Progression of Type C Chronic Hepatitis to Liver Cirrhosis and Hepatocellular Carcinoma—Its Relationship to Alcohol Drinking and the Age of Transfusion

10.1111/j.1530-0277.1996.tb01739.x

Crossref journal-article

Wiley

Alcoholism: Clinical and Experimental Research (311)

Abstract

Alcohol drinking has been reported to be an important factor that modulates the development and prognosis of chronic hepatitis B; however, little is known about an interrelationship between alcohol intake and the progression of chronic hepatitis C to liver cirrhosis (LC) and hepatocellular carcinoma (HCC). We attempted to clarify this interrelationship in patients with hepatitis C and history of blood transfusion. Thirty LC and 85 HCC patients were enrolled. In patients with LC, no significant correlation was observed between the amount of alcohol intake and the period from transfusion to diagnosis. The period from transfusion to diagnosis in HCC patients with alcohol intake ≥46 g/day and < 46 g/day were 26 ± 6 and 31 ± 9 years, respectively, resulting in a significant difference (p < 0.05). The period from transfusion to diagnosis of LC and/or HCC showed significant negative correlation with the age of transfusion (r= 0.82, Y = ‐0.67X+ 48.0, p < 0.01; r= 0.76, Y= ‐0.70X+ 54.1, p < 0.001, respectively). This correlation was also observed in patients with HCC, regardless of the amount of alcohol intake. In conclusion, these data suggest that alcohol drinking might be an important factor that promotes an occurrence of HCC in patients with hepatitis C, and that hepatitis C virus infection in the elderly promotes development of liver disease via LC to HCC.

Bibliography

Noda, K., Yoshihara, H., Suzuki, K., Yamada, Y., Kasahara, A., Hayashi, N., Fusamoto, H., & Kamada, T. (1996). Progression of Type C Chronic Hepatitis to Liver Cirrhosis and Hepatocellular CarcinomaâIts Relationship to Alcohol Drinking and the Age of Transfusion. Alcoholism: Clinical and Experimental Research, 20(s1). Portico.

Authors 8

Katsuhisa Noda (first)
Harumasa Yoshihara (additional)
Kunio Suzuki (additional)
Yukinori Yamada (additional)
Akinori Kasahara (additional)
Norio Hayashi (additional)
Hideyuki Fusamoto (additional)
Takenobu Kamada (additional)

References 30 Referenced 58

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{'key': 'e_1_2_1_25_2', 'first-page': '120', 'article-title': 'Enhancement of dimethylnitrosamine metabolism and activation to a mutagen following chronic alcohol consumption', 'volume': '41', 'author': 'Garroo AJ', 'year': '1981', 'journal-title': 'Cancer Res'} / Cancer Res / Enhancement of dimethylnitrosamine metabolism and activation to a mutagen following chronic alcohol consumption by Garroo AJ (1981)
{'key': 'e_1_2_1_26_2', 'first-page': '511', 'article-title': 'Effect of alcohol drinking on hepatocellular carcinoma at the time of operation', 'volume': '91', 'author': 'Kubo S', 'year': '1994', 'journal-title': 'Jpn J Gastroenterol'} / Jpn J Gastroenterol / Effect of alcohol drinking on hepatocellular carcinoma at the time of operation by Kubo S (1994)
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{'key': 'e_1_2_1_28_2', 'first-page': '173', 'article-title': 'Liver disease in the elderly', 'volume': '31', 'author': 'Tanikawa K', 'year': '1988', 'journal-title': 'Asian Med J'} / Asian Med J / Liver disease in the elderly by Tanikawa K (1988)
{'key': 'e_1_2_1_29_2', 'first-page': '262', 'article-title': 'Viral hepatitis in the elderly', 'volume': '49', 'author': 'Fenster LF', 'year': '1965', 'journal-title': 'An analysis of 23 patients over 65 years of age. Gastroenterology'} / An analysis of 23 patients over 65 years of age. Gastroenterology / Viral hepatitis in the elderly by Fenster LF (1965)
10.1016/S0140-6736(79)92178-0
10.1016/0140-6736(93)91154-E

Dates

Type	When
Created	19 years, 4 months ago (April 11, 2006, 7:26 a.m.)
Deposited	1 year, 11 months ago (Sept. 27, 2023, 3:44 a.m.)
Indexed	1 year, 3 months ago (May 11, 2024, 2:34 a.m.)
Issued	29 years, 7 months ago (Feb. 1, 1996)
Published	29 years, 7 months ago (Feb. 1, 1996)
Published Online	19 years, 4 months ago (April 11, 2006)
Published Print	29 years, 7 months ago (Feb. 1, 1996)

Funders 0

None

BibTeX

@article{Noda_1996, title={Progression of Type C Chronic Hepatitis to Liver Cirrhosis and Hepatocellular Carcinoma—Its Relationship to Alcohol Drinking and the Age of Transfusion}, volume={20}, ISSN={1530-0277}, url={http://dx.doi.org/10.1111/j.1530-0277.1996.tb01739.x}, DOI={10.1111/j.1530-0277.1996.tb01739.x}, number={s1}, journal={Alcoholism: Clinical and Experimental Research}, publisher={Wiley}, author={Noda, Katsuhisa and Yoshihara, Harumasa and Suzuki, Kunio and Yamada, Yukinori and Kasahara, Akinori and Hayashi, Norio and Fusamoto, Hideyuki and Kamada, Takenobu}, year={1996}, month=feb }

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