DOI: 10.1111/j.1476-5381.1995.tb17181.x. On the inhibition of prostanoid formation by SK&F 96365, a blocker of receptor‐operated calcium entry

On the inhibition of prostanoid formation by SK&F 96365, a blocker of receptor‐operated calcium entry

10.1111/j.1476-5381.1995.tb17181.x

Crossref journal-article

Wiley

British Journal of Pharmacology (311)

Abstract

The proposed blocker of receptor‐operated calcium channels, SK&F 96365 was shown to inhibit formation of prostaglandin E2 in two osteoblast‐like cell lines, MC3T3‐E1 and UMR‐106 in a dose‐dependent manner at an IC50 of 3–4 μm. Inhibition was observed with various stimuli (arachidonic acid, bradykinin and calcium ionophore A23187). This effect was also observed in human platelets, where SK&F 96365 dose‐dependently blocked thromboxane biosynthesis and formation of 12‐hydroxy‐heptadecatrienoic acid after stimulation with arachidonic acid (IC50 = 4 μm). The compound had no effect on 12‐hydroxy‐eicosatetraenoic acid production by human platelets. Additionally, linoleic acid oxidation by soybean 15‐lipoxidase was not impaired by SK&F 96365. The results thus provide evidence for cyclo‐oxygenase inhibition by SK&F 96365 at concentrations used to block receptor‐operated calcium influx.

Bibliography

Leis, H. J., Zach, D., Huber, E., Ziermann, L., Gleispach, H., & Windischhofer, W. (1995). On the inhibition of prostanoid formation by SK&F 96365, a blocker of receptorâoperated calcium entry. British Journal of Pharmacology, 114(3), 598â601. Portico.

Authors 6

Hans J. Leis (first)
Doris Zach (additional)
Evelyn Huber (additional)
Laszlo Ziermann (additional)
Helmut Gleispach (additional)
W. Windischhofer (additional)

References 26 Referenced 11

10.1042/bj2800783
10.1002/ijc.2910520522
10.1016/0166-2236(88)90193-2
10.1002/jcb.240501330
10.1016/S0021-9258(18)53024-6 / J. Biol. Chem. / Muscarinic Receptor‐mediated Tyrosine Phosphorylation of Phospholipase C‐gamma by GUSOVSKY F. (1993)
10.1016/0165-6147(89)90092-8
10.1016/0014-4827(92)90050-I
10.2330/joralbiosci1965.23.899
10.1016/0304-3835(93)90014-Z
10.1002/bms.1200141108
10.1016/0003-2697(87)90401-5
10.1002/bms.1200130906
10.1016/0143-4160(94)90109-0
10.1016/0262-1746(87)90059-X
10.1152/ajpcell.1993.264.3.C654
10.1016/S0378-4347(00)80738-0
10.1016/0014-4827(87)90161-3
10.1042/bj2710515
{'key': 'e_1_2_1_20_1', 'first-page': '3', 'volume-title': 'Methods in Enzymology', 'author': 'MUSTARD J.F.', 'year': '1989'} / Methods in Enzymology by MUSTARD J.F. (1989)
{'key': 'e_1_2_1_21_1', 'first-page': '650', 'article-title': 'Role of arachidonic acid metabolism in the mitogenic response of BALB/c 3T3 fibroblasts to epidermal growth factor', 'volume': '33', 'author': 'NOLAN R.D.', 'year': '1988', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. / Role of arachidonic acid metabolism in the mitogenic response of BALB/c 3T3 fibroblasts to epidermal growth factor by NOLAN R.D. (1988)
10.1016/0014-4827(92)90103-F
10.1016/0143-4160(94)90103-1
10.1016/0006-2952(86)90224-8
10.1016/0166-2236(88)90194-4
10.1006/bbrc.1993.2126
10.1038/334703a0

Dates

Type	When
Created	13 years, 1 month ago (July 19, 2012, 4:08 p.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 6:43 p.m.)
Indexed	1 year, 3 months ago (May 12, 2024, 1:56 p.m.)
Issued	30 years, 7 months ago (Feb. 1, 1995)
Published	30 years, 7 months ago (Feb. 1, 1995)
Published Online	13 years, 1 month ago (July 19, 2012)
Published Print	30 years, 7 months ago (Feb. 1, 1995)

Funders 0

None

BibTeX

@article{Leis_1995, title={On the inhibition of prostanoid formation by SK&F 96365, a blocker of receptor‐operated calcium entry}, volume={114}, ISSN={1476-5381}, url={http://dx.doi.org/10.1111/j.1476-5381.1995.tb17181.x}, DOI={10.1111/j.1476-5381.1995.tb17181.x}, number={3}, journal={British Journal of Pharmacology}, publisher={Wiley}, author={Leis, Hans J. and Zach, Doris and Huber, Evelyn and Ziermann, Laszlo and Gleispach, Helmut and Windischhofer, W.}, year={1995}, month=feb, pages={598–601} }

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